In‐hospital neonatal mortality and the role of consanguinity

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dc.contributor.author Matar, Maroun
dc.contributor.author Charafeddine, Lama
dc.contributor.author Ammous, Farah
dc.contributor.author Kobeissi, Loulou
dc.contributor.author De Ver Dye, Timothy
dc.contributor.author Faddous Khalife, Marie Claude
dc.contributor.author Yunis, Khalid
dc.date.accessioned 2019-04-09T07:10:55Z
dc.date.available 2019-04-09T07:10:55Z
dc.date.copyright 2012 en_US
dc.date.issued 2019-04-09
dc.identifier.issn 1365-3016 en_US
dc.identifier.uri http://hdl.handle.net/10725/10374
dc.description.abstract Abstract Background: Consanguinity which increases the risk of genetic disorders has been implicated at times in infant mortality. The aim of this study was to determine the association between consanguinity and in‐hospital mortality in newborns. Methods: Data was collected prospectively on all births from 26 hospitals in Lebanon from January 2004 to December 2008 and admitted to the National Collaborative Perinatal Neonatal Network. Secondary analysis was done on 65,402 singletons, after exclusion of stillbirths, infants of multiple gestation and infants of second cousin progeny. Results: In‐hospital mortality was 6.7 per 1000 live births (439/65,402). The rate of first cousin marriage was 9.9%. Consanguinity was significantly associated with in‐hospital mortality (odds ratio 2.4; 95% confidence interval (CI): 1.8, 3.1); consanguinity remained a significant predictor of mortality (odds ratio 1.8 [95% CI: 1.2, 2.9]) after adjusting for maternal age and education, crowding index, history of abortion, prenatal care, mode of delivery, gender, birthweight and apgar score at 5 minutes. Conclusions: This association of consanguinity with in‐hospital mortality points to potential genetic factors leading to this increased risk. Designing public health interventions, including raising the awareness and taking into consideration such risks in neonatal mortality studies are indicated. en_US
dc.language.iso en en_US
dc.title In‐hospital neonatal mortality and the role of consanguinity en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201004811 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Pediatric and Perinatal Epidemiology en_US
dc.journal.volume 26 en_US
dc.journal.issue 5 en_US
dc.article.pages 398-407 en_US
dc.keywords Consanguinity en_US
dc.keywords Developing countries en_US
dc.keywords Genetics en_US
dc.keywords hospital mortality en_US
dc.keywords Infant mortality en_US
dc.identifier.doi https://doi.org/10.1111/j.1365-3016.2012.01295.x en_US
dc.identifier.ctation Charafeddine, L., Ammous, F., Kobeissi, L., De Ver Dye, T., Matar, M., Faddous Khalife, M. C., & Yunis, K. (2012). In‐hospital Neonatal Mortality and the Role of Consanguinity. Paediatric and perinatal epidemiology, 26(5), 398-407. en_US
dc.author.email maroun.matar@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-3016.2012.01295.x en_US
dc.author.affiliation Lebanese American University en_US

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