Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation

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dc.contributor.author Georgess, Dan
dc.contributor.author Spuul, Pirjo
dc.contributor.author Le Clainche, Christophe
dc.contributor.author Le Nihouannen, Damien
dc.contributor.author Fremaux, Isabelle
dc.contributor.author Dakhli, Thierry
dc.date.accessioned 2019-04-04T12:15:02Z
dc.date.available 2019-04-04T12:15:02Z
dc.date.copyright 2018 en_US
dc.date.issued 2019-04-04
dc.identifier.uri http://hdl.handle.net/10725/10344
dc.description.abstract Actin subunits assemble into actin filaments whose dynamics and three-dimensional architectures are further regulated by a variety of cellular factors to establish the functional actin cytoskeleton. The C-glucosidic ellagitannin vescalagin and its simpler analogue vescalin, affect both the dynamics and the ultrastructure of the actin cytoskeleton by directly binding to F-actin. Herein, we show that in vitro, the two compounds induce the formation of distinct F-actin networks characterized by different superstructures and dynamics. In living mature osteoclasts, highly specialized bone-degrading cells that constantly remodel their cytoskeleton, vescalagin and vescalin alter actin dynamics at podosomes and compromise the integrity of the podosome belt that forms the bone-degrading apparatus. Both compounds target the bone-resorbing activity at concentrations that preserve osteoclastic maturation and survival and with no detectable impact on the behaviour of bone-forming osteoblastic cells. This anti-osteoclastic activity of vescalagin and vescalin reveals the potential of targeting actin dynamics as a new therapeutic opportunity and, in this case, as a plausible approach for the local treatment of osteoporosis. en_US
dc.language.iso en en_US
dc.title Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201900498 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal European Journal of Cell Biology en_US
dc.journal.volume 97 en_US
dc.journal.issue 8 en_US
dc.article.pages 533-545 en_US
dc.keywords Cytoskeleton en_US
dc.keywords Actin dynamics en_US
dc.keywords Podosomes en_US
dc.keywords Osteoclast biology en_US
dc.keywords Medicinal biology en_US
dc.keywords Polyphenol sciences en_US
dc.identifier.doi https://doi.org/10.1016/j.ejcb.2018.09.003 en_US
dc.identifier.ctation Georgess, D., Spuul, P., Le Clainche, C., Le Nihouannen, D., Fremaux, I., Dakhli, T., ... & Génot, E. (2018). Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation. European journal of cell biology, 97(8), 533-545. en_US
dc.author.email dan.georgess@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S0171933517303229 en_US
dc.author.affiliation Lebanese American University en_US

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