Cognition and physical functioning in patients with schizophrenia: any role for vitamin D?

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dc.contributor.author Azar, Jocelyne
dc.contributor.author Zoghbi, Marouan
dc.contributor.author Haddad, Chadi
dc.contributor.author Hallit, Souheil
dc.contributor.author Nabout, Rita
dc.contributor.author Medlej-Hashim, Myrna
dc.contributor.author Hachem, Dory
dc.date.accessioned 2019-04-01T08:38:57Z
dc.date.available 2019-04-01T08:38:57Z
dc.date.copyright 2019 en_US
dc.date.issued 2019-04-01
dc.identifier.issn 1476-8305 en_US
dc.identifier.uri http://hdl.handle.net/10725/10307
dc.description.abstract Aim: The study’s objective was to evaluate the relationship between vitamin D (VD) levels and cognitive performance in patients with schizophrenia. Methods: A cross-sectional study, conducted between March and July 2016, recruited 196 patients with schizophrenia. The Brief Cognitive Rating Scale (BCRS) and the Morningside Rehabilitation Status Scale (MRSS) were used to measure the severity of cognitive impairment and the level of general functioning in psychiatric patients. Lower scores for both scales indicate a better cognition and functioning respectively. Vitamin D levels of participants were divided into four groups: severe VD deficiency (<10 ng/ml), VD deficiency (10–20 ng/ml), VD insufficiency (20–30 ng/ml), VD sufficiency (>30 ng/ml). Relationships between VD level and cognition and functioning were assessed by analyses of covariance and hierarchical multiple regression, adjusted for age, gender, marital status, education level, sun exposure, physical activity and monthly income. Results: Severe VD deficiency was found in 22 patients with schizophrenia (11.3%), while 45.6% of patients had VD deficiency. Severe VD deficiency was significantly associated with an increase in MRSS score after adjusting for covariates (Beta = 2.44), however, no significant association was found with the BCRS score. Conclusion: These findings suggest that severe VD deficiency in patients with schizophrenia might be associated with low general functioning but could not influence cognitive function. en_US
dc.language.iso en en_US
dc.title Cognition and physical functioning in patients with schizophrenia: any role for vitamin D? en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201201426 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Nutritional Neuroscience en_US
dc.article.pages 1-9 en_US
dc.keywords Vitamin D en_US
dc.keywords BCRS en_US
dc.keywords MRSS en_US
dc.keywords Schizophrenia en_US
dc.keywords Cognitive impairment en_US
dc.keywords General functioning en_US
dc.identifier.doi https://doi.org/10.1080/1028415X.2019.1580830 en_US
dc.identifier.ctation Zoghbi, M., Haddad, C., Hallit, S., Nabout, R., Medlej-Hashim, M., Hachem, D., & Azar, J. (2019). Cognition and physical functioning in patients with schizophrenia: any role for vitamin D?. Nutritional neuroscience, 1-9. en_US
dc.author.email jocelyne.azar@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.tandfonline.com/doi/abs/10.1080/1028415X.2019.1580830 en_US
dc.author.affiliation Lebanese American University en_US

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