Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer

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dc.contributor.author Akoury, Elias
dc.contributor.author Mukrasch, Marco D.
dc.contributor.author Biernat, Jacek
dc.contributor.author Tepper, Katharina
dc.contributor.author Ozenne, Valery
dc.contributor.author Mandelkow, Eckhard
dc.contributor.author Blackedge, Martin
dc.contributor.author Zweckstetter, Markus
dc.date.accessioned 2019-03-22T09:08:56Z
dc.date.available 2019-03-22T09:08:56Z
dc.date.copyright 2016 en_US
dc.identifier.issn 1469-896X en_US
dc.identifier.uri http://hdl.handle.net/10725/10254
dc.description.abstract Misfolding of the microtubule‐associated protein Tau is a hallmark of Alzheimer disease and several other neurodegenerative disorders. Because of the dynamic nature of the Tau protein, little is known about the changes in Tau structure that occur during misfolding. Here we studied the structural consequences upon binding of the repeat domain of Tau, which plays a key role in pathogenic aggregation, to an aggregation enhancer. By combining NMR experiments with molecular simulations we show that binding of the aggregation enhancer polyglutamic acid remodels the conformational ensemble of Tau. Our study thus provides insight into an early event during misfolding of Tau. en_US
dc.language.iso en en_US
dc.title Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201900590 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Protein Science en_US
dc.journal.volume 25 en_US
dc.journal.issue 5 en_US
dc.article.pages 1010-1020 en_US
dc.keywords Alzheimer disease en_US
dc.keywords NMR spectroscopy en_US
dc.keywords Tau en_US
dc.keywords Protein misfolding en_US
dc.keywords Structure en_US
dc.identifier.doi https://doi.org/10.1002/pro.2911 en_US
dc.identifier.ctation Akoury, E., Mukrasch, M. D., Biernat, J., Tepper, K., Ozenne, V., Mandelkow, E., ... & Zweckstetter, M. (2016). Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein Science, 25(5), 1010-1020. en_US
dc.author.email elias.akoury@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://onlinelibrary.wiley.com/doi/full/10.1002/pro.2911 en_US
dc.orcid.id https://orcid.org/0000-0001-5202-8935 en_US
dc.author.affiliation Lebanese American University en_US

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