Aortic stiffness, living donors, and renal transplantation

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dc.contributor.author Bahous, Sola Aoun
dc.contributor.author Stephan, Antoine
dc.contributor.author Blacher, Jacques
dc.contributor.author Safar, Michel E.
dc.date.accessioned 2019-02-27T14:23:22Z
dc.date.available 2019-02-27T14:23:22Z
dc.date.copyright 2006 en_US
dc.identifier.issn 0194-911X en_US
dc.identifier.uri http://hdl.handle.net/10725/10103
dc.description.abstract In subjects with renal disease, reduced renal function and increased arterial stiffness are significantly associated in cross-sectional studies. The relationship is independent of age, blood pressure (BP), and atherosclerosis. Because both variables are independent predictors of cardiovascular risk, time-dependent relationships between them are important to determine. Aortic pulse wave velocity was measured noninvasively by comparison with healthy volunteers in 101 living kidney donors and their 101 corresponding recipients. Healthy volunteers were divided into 2 groups: one was recipient related through familial links and the other was nonrecipient related. Independently of age, gender, and BP, pulse wave velocity was significantly elevated in donors and recipients by comparison with the 2 groups of healthy volunteers. Pulse wave velocity was significantly higher in the recipient-related than in the nonrecipient-related group. Whereas in healthy volunteers, pulse wave velocity was exclusively related to age, gender, and BP, in donors and recipients, it was rather associated with a cluster of cardiovascular risk factors, including smoking habits and plasma glucose. Major factors related to pulse wave velocity were renal: time since nephrectomy (donation date) in donors, in whom pulse pressure was specifically associated with proteinuria, and renal rejection in recipients. Plasma creatinine doubling secondary to chronic allograft nephropathy was significantly associated with renal rejection and donor pulse wave velocity, independent of age. Our findings strongly suggest consistent interactions (including familial factors) between kidney function and arterial stiffness. Assessment of cause–effect relationships and implication of biochemical and/or genetic factors warrant additional studies. en_US
dc.language.iso en en_US
dc.title Aortic stiffness, living donors, and renal transplantation en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200803754 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Hypertension en_US
dc.journal.volume 47 en_US
dc.journal.issue 2 en_US
dc.article.pages 216-221 en_US
dc.keywords Transplantation, renal en_US
dc.keywords Kidney en_US
dc.keywords Arteries en_US
dc.keywords Pulse en_US
dc.keywords Risk factors en_US
dc.identifier.doi https://doi.org/10.1161/01.HYP.0000201234.35551.2e en_US
dc.identifier.ctation Bahous, S. A., Stephan, A., Blacher, J., & Safar, M. E. (2006). Aortic stiffness, living donors, and renal transplantation. Hypertension, 47(2), 216-221. en_US
dc.author.email sola.bahous@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.0000201234.35551.2e en_US
dc.orcid.id https://orcid.org/0000-0002-7159-7559 en_US
dc.author.affiliation Lebanese American University en_US

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