T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

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dc.contributor.author Hirbli, Kamal
dc.contributor.author Zalloua, Pierre A.
dc.contributor.author Ghassibe-Sabbagh, Michela
dc.contributor.author Haber, Marc
dc.contributor.author Salloum, Angelique K.
dc.contributor.author Al-Sarraj, Yasser
dc.contributor.author Akle, Yasmine
dc.contributor.author Romanos, Jihane
dc.contributor.author Mouzaya, Francis
dc.contributor.author Gaugier, Dominique
dc.contributor.author Platt, Daniel E.
dc.contributor.author El Shanti, Hatem
dc.date.accessioned 2019-02-27T08:24:51Z
dc.date.available 2019-02-27T08:24:51Z
dc.date.copyright 2014 en_US
dc.date.issued 2019-02-27
dc.identifier.issn 2045-2322 en_US
dc.identifier.uri http://hdl.handle.net/10725/10098
dc.description.abstract Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10−9) and rs34872471 (OR = 1.35, P = 1.01 × 10−8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease. en_US
dc.language.iso en en_US
dc.title T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201000156 en_US
dc.author.idnumber 200300001 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Scientific Reports en_US
dc.journal.volume 4 en_US
dc.identifier.ctation Ghassibe-Sabbagh, M., Haber, M., Salloum, A. K., Al-Sarraj, Y., Akle, Y., Hirbli, K., ... & El-Shanti, H. (2014). T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility. Scientific reports, 4, 7351. en_US
dc.author.email kamal.hirbli@lau.edu.lb en_US
dc.author.email pierre.zalloua@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.nature.com/articles/srep07351 en_US
dc.author.affiliation Lebanese American University en_US

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