Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial

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dc.contributor.author Kilany, Hala
dc.contributor.author Karam, Albert
dc.contributor.author Bahous, Sola Aoun
dc.contributor.author Mansour, Anthony G.
dc.contributor.author Hariri, Essa
dc.contributor.author Daaboul, Yazan
dc.contributor.author Korjian, Serge
dc.contributor.author El Alam, Andrew
dc.contributor.author Protogerou, Athanase D.
dc.contributor.author Stephan, Antoine
dc.date.accessioned 2019-02-22T14:51:26Z
dc.date.available 2019-02-22T14:51:26Z
dc.date.copyright 2017 en_US
dc.date.issued 2019-02-22
dc.identifier.issn 1933-1711 en_US
dc.identifier.uri http://hdl.handle.net/10725/10073
dc.description.abstract ubclinical vitamin K deficiency is prevalent among renal transplant recipients and is associated with an increased risk of cardiovascular disease. However, the association between vitamin K supplementation and improvement of arterial stiffness has not been explored in the renal transplant population. The KING trial (vitamin K2 In reNal Graft) is a single-arm study that evaluated the association between the change in vitamin K status and indices of arterial stiffness following 8 weeks of menaquinone-7 (vitamin K2) supplementation (360 μg once daily) among renal transplant recipients (n = 60). Arterial stiffness was measured using carotid-femoral pulse wave velocity (cfPWV). Subclinical vitamin K deficiency was defined as plasma concentration of dephosphorylated-uncarboxylated matrix Gla protein (dp-ucMGP) >500 pmol/L.At baseline, 53.3% of the study subjects had subclinical vitamin K deficiency. Supplementation was associated with a 14.2% reduction in mean cfPWV at 8 weeks (cfPWV pre-vitamin K2 = 9.8 ± 2.2 m/s vs. cfPWV post-vitamin K2 = 8.4 ± 1.5 m/s; P < .001). Mean dp-ucMGP concentrations were also significantly reduced by 55.1% following menaquinone-7 supplementation with a reduction in the prevalence of subclinical deficiency by 40% ( P = .001). When controlled for age, durations of hemodialysis and transplantation, and the change in 24-hour mean arterial pressure, the improvement in arterial stiffness was independently associated with the reduction in dp-ucMGP concentration ( P = .014).Among renal transplant recipients with stable graft function, vitamin K2 supplementation was associated with improvement in subclinical vitamin K deficiency and arterial stiffness en_US
dc.language.iso en en_US
dc.title Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201004806 en_US
dc.author.idnumber 201000157 en_US
dc.author.idnumber 200803754 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of the American Society of Hypertension en_US
dc.journal.volume 11 en_US
dc.journal.issue 9 en_US
dc.article.pages 589-597 en_US
dc.keywords Menaquinone en_US
dc.keywords Pulse wave velocity en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.jash.2017.07.001 en_US
dc.identifier.ctation Mansour, A. G., Hariri, E., Daaboul, Y., Korjian, S., El Alam, A., Protogerou, A. D., ... & Bahous, S. A. (2017). Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial. Journal of the American Society of Hypertension, 11(9), 589-597. en_US
dc.author.email hala.kilani@lau.edu.lb en_US
dc.author.email albert.karam@lau.edu.lb en_US
dc.author.email sola.bahous@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S1933171117302553 en_US
dc.orcid.id https://orcid.org/0000-0002-7159-7559 en_US
dc.author.affiliation Lebanese American University en_US

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