Renal Function Decline in Recipients and Donors of Kidney Grafts

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dc.contributor.author Bahous, Sola Aoun
dc.contributor.author Khairallah, Maya
dc.contributor.author Al Danaf, Jad
dc.contributor.author Halaby, Rim
dc.contributor.author Korjian, Serge
dc.contributor.author Daaboul, Yazan
dc.contributor.author Salameh, Pascale
dc.contributor.author Stephan, Antoine
dc.contributor.author Blacher, Jacques
dc.contributor.author Safar, Michel E.
dc.date.accessioned 2019-02-21T08:06:55Z
dc.date.available 2019-02-21T08:06:55Z
dc.date.copyright 2015 en_US
dc.date.issued 2019-02-21
dc.identifier.issn 0250-8095 en_US
dc.identifier.uri http://hdl.handle.net/10725/10067
dc.description.abstract Background/Aims: Renal function decreases over time as a result of reduction in the number of functioning nephrons with age. In recipients and donors of kidney grafts, renal function decline may be linked differently to various parameters, namely arterial stiffness. Methods: We conducted a prospective cohort study including 101 recipients of kidney grafts and their donors aiming at determining the factors correlated to the renal function decline over time. Aortic stiffness was evaluated by the non-invasive measurement of aortic pulse wave velocity. The glomerular filtration rate was estimated using the Modification of Diet in Renal Disease (MDRD) equation and the annualized change was determined. Results: Decline in renal function was estimated at 1-year post-transplantation and annually thereafter (median follow-up 8 years, range 3.6-18.3), as the mean of the annualized decrease in the glomerular filtration rate. In recipients, filtration rate decreased by 4.8 ± 19.7 ml/min/1.73 m2 the first post-transplant year and at a yearly rate of 2.2 ± 3.8 ml/min/1.73 m2 thereafter. The first-year decline was related to smoking and acute rejection. Later decline was significantly associated with donor age and aortic stiffness. In living donors, renal function decline after the first year corresponded to 0.7 ml/min/1.73 m2, was significantly lower than that of recipients (p < 0.001), and was determined by donor age at nephrectomy. Conclusion: Recipients of kidney grafts show a glomerular filtration rate decline over time that is significantly associated with donor age and aortic stiffness after the first post-transplant year, while donors demonstrate a lower decline that is mostly determined by age at nephrectomy. en_US
dc.language.iso en en_US
dc.title Renal Function Decline in Recipients and Donors of Kidney Grafts en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Role of Aortic Stiffness en_US
dc.author.school SOM en_US
dc.author.idnumber 200803754 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal American Journal of Nephrology en_US
dc.journal.volume 41 en_US
dc.journal.issue 1 en_US
dc.article.pages 57-65 en_US
dc.keywords Arteries en_US
dc.keywords Donor en_US
dc.keywords Glomerular filtration rate en_US
dc.keywords Kidney en_US
dc.keywords Transplantation en_US
dc.keywords Renal en_US
dc.identifier.doi https://doi.org/10.1159/000371858 en_US
dc.identifier.ctation Bahous, S. A., Khairallah, M., Al Danaf, J., Halaby, R., Korjian, S., Daaboul, Y., ... & Safar, M. E. (2015). Renal function decline in recipients and donors of kidney grafts: role of aortic stiffness. American journal of nephrology, 41(1), 57-65. en_US
dc.author.email sola.bahous@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.karger.com/Article/Abstract/371858 en_US
dc.orcid.id https://orcid.org/0000-0002-7159-7559 en_US
dc.author.affiliation Lebanese American University en_US

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