Aortic pulse wave velocity in renal transplant patients

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dc.contributor.author Bahous, Sola Aoun
dc.contributor.author Stephan, Antoine
dc.contributor.author Barakat, Wadad
dc.contributor.author Blacher, Jacques
dc.contributor.author Asmar, Roland
dc.contributor.author Safar, Michel E.
dc.date.accessioned 2019-02-20T13:00:15Z
dc.date.available 2019-02-20T13:00:15Z
dc.date.copyright 2004 en_US
dc.date.issued 2019-02-20
dc.identifier.issn 0085-2538 en_US
dc.identifier.uri http://hdl.handle.net/10725/10058
dc.description.abstract In subjects with end-stage renal disease (ESRD) undergoing hemodialysis, aortic pulse wave velocity (PWV) is increased independently of blood pressure level and mostly is a strong predictor of cardiovascular risk. Few studies on this subject have been performed in renal transplant patients. Methods Aortic PWV was determined noninvasively in 106 patients with kidney transplantation and treated using a standard immunosuppression protocol. Mean age was 43 ± 14 years. During the follow-up period (mean duration 54.3 ± 28.9 months), the following parameters were studied: characteristics of the renal graft, degree of renal insufficiency, number of acute rejections, cardiovascular risk factors, drug medications, and cardiovascular complications. Results Aortic PWV was increased in subjects with renal transplants independently of age and mean blood pressure. Acute renal rejection and smoking habits were the principal factors modulating together: the increase of aortic PWV and the reduction of the glomerular filtration rate (GFR). The latter renal parameter was also influenced by the donor age. Two main parameters were predictors of cardiovascular events: a past history of cardiovascular disease and the pulse pressure × heart rate product, the major mechanical consequence of increased PWV. Conclusion In renal transplant subjects, tobacco consumption and mostly acute renal rejection modulate both aortic stiffness and chronic renal failure independent of blood pressure level and donor characteristics. Pulsatile stress mediates cardiovascular complications and predicts cardiovascular risk, particularly in the presence of increased heart rate. en_US
dc.language.iso en en_US
dc.title Aortic pulse wave velocity in renal transplant patients en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200803754 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Kidney International en_US
dc.journal.volume 66 en_US
dc.journal.issue 4 en_US
dc.article.pages 1486-1492 en_US
dc.keywords Pulse wave velocity en_US
dc.keywords Arterial stiffness en_US
dc.keywords Renal transplantation en_US
dc.identifier.doi https://doi.org/10.1111/j.1523-1755.2004.00912.x en_US
dc.identifier.ctation Bahous, S. A., Stephan, A., Barakat, W., Blacher, J., Asmar, R., & Safar, M. E. (2004). Aortic pulse wave velocity in renal transplant patients. Kidney international, 66(4), 1486-1492. en_US
dc.author.email sola.bahous@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S0085253815502160 en_US
dc.orcid.id https://orcid.org/0000-0002-7159-7559 en_US
dc.author.affiliation Lebanese American University en_US

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