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dc.contributor.author Nawas, Tarek
dc.contributor.author Abou Raji El Feghali, Patrick
dc.date.accessioned 2019-02-20T11:39:22Z
dc.date.available 2019-02-20T11:39:22Z
dc.date.copyright 2018 en_US
dc.date.issued 2019-02-20
dc.identifier.issn 2639-4553 en_US
dc.identifier.uri http://hdl.handle.net/10725/10055
dc.description.abstract Pyocyanin, a pigment naturally produced by most Pseudomonas aeruginosa strains and noted to have a role in the wellbeing of the organism and its pathogenicity, was studied for its role as an inhibitor of bacterial growth and biofilm formation of many clinical bacterial isolates. The organisms included in the study were 33isolates of 11 different bacterial species. The results showed that most of the Gram-positive isolates from the 3species included in the study: Staphylococcus aureus, Staphylococcus saprophyticus and Enterococcus fecal is were inhibited at low concentrations of pyocyanin. The results varied for the Gram-negative organisms tested. Whereas the growth of the Escherichia coli, Citrobacter koseri, Enterobacter cloacae and A. baumannii isolates was clearly inhibited even by low concentrations of pyocyanin, the growth of Klebsiella pneumonia, Proteus mirabilis and Morganella morganii was not affected even by higher concentrations of pyocyanin. The methanol extract of the pigment was highly effective in preventing the biofilm forming ability of all S. saprophyticus, A. baumannii, E. cloacae and K. pneumoniae isolates, 3 of the 4 P. mirabilis isolates and 2 of the 5 E. coli isolates. All the other isolates tested, also showed a moderate antibiofilm activity This study revealed that pyocyanin has a powerful inhibitory effect on the bacterial growth and/or biofilm forming ability of the numerous clinically significant isolates tested, a characteristic that can prove valuable in developing new drugs for the treatment and prevention of different bacterial infections, once its safety for regular use has been assessed. en_US
dc.language.iso en en_US
dc.title Pyocyanin en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle a powerful inhibitor of bacterial growth and biofilm formation en_US
dc.author.school SAS en_US
dc.author.idnumber 198029370 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal International Journal of Case Reports & Studies en_US
dc.journal.volume 3 en_US
dc.journal.issue 1 en_US
dc.article.pages 101-107 en_US
dc.keywords Pyocyanin en_US
dc.keywords Antibacterial activity en_US
dc.keywords Inhibition of biofilm formation en_US
dc.keywords Bacterial pigment en_US
dc.keywords Pseudomonas aeruginosa en_US
dc.identifier.ctation Abou Raji El Feghali P. &Nawas T. (2018). Pyocyanin: A Powerful Inhibitor of Bacterial Growth and Biofilm Formation. International journal of case reports & studies. 2018; 2(2): 101-107. en_US
dc.author.email tnawas@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.madridge.org/journal-of-case-reports-and-studies/mjcrs-1000125.pdf en_US
dc.author.affiliation Lebanese American University en_US

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