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HIV associated pulmonary emphysema

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dc.contributor.author Diab, K.
dc.contributor.author Petrache, I.
dc.contributor.author Twigg, H. L.
dc.contributor.author Stephens, R. S.
dc.contributor.author Flores, S.
dc.contributor.author Tuder, R. M.
dc.date.accessioned 2019-02-13T13:41:14Z
dc.date.available 2019-02-13T13:41:14Z
dc.date.copyright 2007 en_US
dc.identifier.issn 0040-6376 en_US
dc.identifier.uri http://hdl.handle.net/10725/10039
dc.description.abstract Chronic lung diseases are increasingly recognised complications of the human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS). Of these, pulmonary emphysema, characterised by permanent destruction of the lung parenchyma distal to the terminal bronchioles accompanied by various degrees of inflammation, is emerging as a distinct source of morbidity for patients infected with HIV. Similarly, HIV is now frequently cited as a susceptibility factor for the development of emphysema, independent of cigarette smoking status. The presence of common coexistent confounding factors that may predispose patients to chronic lung injury such as drugs, opportunistic infections and malnutrition, limits the scope of studies of direct mechanisms involved in HIV associated emphysematous lung disease. We review the clinical studies supporting a direct association between HIV infection and emphysema. Recent developments in the basic understanding of HIV infection and emphysema are also reviewed, since they may aid in understanding the pathobiology of HIV associated emphysema. The authors emphasise how HIV infection may affect cytotoxic lymphocyte activation, lung capillary endothelial cell injury and apoptosis, sphingolipid imbalance and oxidative stress in the lung. A better understanding of the pathogenesis of HIV associated pulmonary emphysema may provide clues and therapeutic targets that have broader application in this disease, including cigarette smoke induced emphysema. en_US
dc.language.iso en en_US
dc.title HIV associated pulmonary emphysema en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle a review of the literature and inquiry into its mechanism en_US
dc.author.school SOM en_US
dc.author.idnumber 201900605 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Thorax en_US
dc.journal.volume 63 en_US
dc.article.pages 463-469 en_US
dc.identifier.doi http://dx.doi.org/10.1136/thx.2007.079111 en_US
dc.identifier.ctation Petrache, I., Diab, K., Knox, K. S., Twigg, H. L., Stephens, R. S., Flores, S., & Tuder, R. M. (2008). HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanism. Thorax, 63(5), 463-469. en_US
dc.author.email khalil.diab@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://thorax.bmj.com/content/63/5/463.short en_US
dc.orcid.id https://orcid.org/0000-0001-9255-7575 en_US
dc.author.affiliation Lebanese American University en_US


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