Fluorescence or Förster resonance energy transfer (FRET) is a quantitative transfer of energy between two fluorescent moieties in proximal distance, between 10Å and 100Å. The energy transfer is useful in studying direct ...

Astrocytomas, with their different grades, occur in young adulthood. Malignant astrocytomas are characterized by uncontrolled proliferation and a high invasiness profile to adjacent normal regions of the brain. The ...

DJ-1 is a 20-KDa protein that was first identified as an oncogene product responsible for a subset of familial Parkinson’s disease; hence its name PARK 7. Previous studies showed that DJ-1 negatively regulated the tumor ...

Ovarian carcinoma is eighth most common leading cause of death among all mortality causes globally. It is among the most common gynecological cancers. Diagnosis of this type of cancer is very challenging due to frequently ...

Astrocytomas are characterized by uncontrolled proliferation and high invasion to adjacent normal regions of the brain. They originate from the normal glial cells, astrocytes. Astrocytomas are also referred to as glioblastoma, ...

Glioblastoma multiforme (GBM), also referred to as glioblastoma is a rapidly dividing glioma that develops from astrocytes and oligodendrocytes (glial cells that nourish the brain). GBM can also be classified as a grade ...

Malignant astrocytomas are associated with high mortality rates; these tumors are highly invasive into adjacent areas of the normal brain. It has been established that Rho family of GTPases play a central role in regulation ...

Metastasis is the movement of a tumor from its original site to a secondary site. The ability of cancer cells to metastasize depends on their motility and actin-rich membrane protrusions. These protrusions and motility are ...

As the tumor size increases, cancer cells stimulate neighboring vascular endothelial cells to proliferate and form new blood vessels in order to irrigate the tumor. This is through the secretion of vascular endothelial ...