LAUR Home
→
Browsing by Subject

Browsing by Subject "Mitogen-activated protein kinases"

Now showing items 1-6 of 6

Characterization of the Cytotoxic Mechanism and Mode of Cell Death Induced by a MEK1/2-selective version of Anthrax Lethal Toxin (PrAg/LFW271A) in Acute Myeloid Leukemia

Mroue, Zeinab (Lebanese American University, 2023-05-17)

Wild-type anthrax lethal toxin (PrAg/LF) demonstrated high potency in inhibiting the MAPK pathway in AML cell lines that rely on this pathway for survival. PrAg/LF is a binary toxin consisting of protective antigen (PrAg), ...
Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute myeloid leukemia

Farhat, Mirna (Lebanese American University, 2023-05-17)

Anthrax lethal toxin (PrAg/LF) is a binary toxin consisting of protective antigen (PrAg), the cell binding moiety, and lethal factor (LF), the catalytic moiety. Inside the cell, LF cleaves MEKs and subsequently leads to ...
Dual Targeting of Matrix Metalloproteases and the MAPK Pathway in Acute Myeloid Leukemia Cells Using an MMP-activated anthrax lethal toxin (PrAgL1/LF)

Al Saneh, Ahmad (Lebanese American University, 2020-05-27)

Anthrax lethal toxin is a two-component toxin consisting of protective antigen (PrAg), the cell binding and translocation domain, and lethal factor (LF), the catalytic domain, which cleaves all mitogen-activated ...
The Effect of Recombinant Anthrax Lethal Toxin on Breast Cancer Cell Motility, Adhesion, and Invasion

El Chami, Dana (Lebanese American University, 2020-05-18)

Breast cancer-related deaths are mostly due to breast cancer invasion and migration to distant secondary regions. Targeting breast cancer cell metastasis is an important therapeutic approach. The mitogen-activated protein ...
Sensitivity of acute myeloid leukemia cells to the dual targeting of the urokinase plasminogen activator and the MAPK pathway by a urokinase-activated anthrax lethal toxin. (c2013)

Bekdash, Amira (Lebanese American University, 2013-09-03)

Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by abnormal proliferation of myeloid progenitor cells. Around 15,000 new case of AML are diagnosed each year with a fatality rate of 65%. Conventional ...
Targeting the MAP Kinase pathway in human acute myeloid leukemia cells using a recombinant anthrax lethal toxin. (c2013)

Kassab, Elias (Lebanese American University, 2013-09-03)

In this study, we attempt to target the mitogen-activated protein kinase (MAPK) pathway in acute myeloid leukemia (AML) cells using a recombinant anthrax lethal toxin (LeTx). Around 15,000 new case of Acute Myeloid Leukemia ...

Now showing items 1-6 of 6

Search LAUR

Advanced Search

Browse

All of LAUR

Browsing by Subject "Mitogen-activated protein kinases"

LAUR Repository

Browsing by Subject "Mitogen-activated protein kinases"

Search LAUR

Browse

All of LAUR

My Account