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Browsing by Subject "Acute myeloid leukemia -- Pathogensis"

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Characterization of the Cytotoxic Mechanism and Mode of Cell Death Induced by a MEK1/2-selective version of Anthrax Lethal Toxin (PrAg/LFW271A) in Acute Myeloid Leukemia

Mroue, Zeinab (Lebanese American University, 2023-05-17)

Wild-type anthrax lethal toxin (PrAg/LF) demonstrated high potency in inhibiting the MAPK pathway in AML cell lines that rely on this pathway for survival. PrAg/LF is a binary toxin consisting of protective antigen (PrAg), ...
Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute myeloid leukemia

Farhat, Mirna (Lebanese American University, 2023-05-17)

Anthrax lethal toxin (PrAg/LF) is a binary toxin consisting of protective antigen (PrAg), the cell binding moiety, and lethal factor (LF), the catalytic moiety. Inside the cell, LF cleaves MEKs and subsequently leads to ...
Dual Targeting of Matrix Metalloproteases and the MAPK Pathway in Acute Myeloid Leukemia Cells Using an MMP-activated anthrax lethal toxin (PrAgL1/LF)

Al Saneh, Ahmad (Lebanese American University, 2020-05-27)

Anthrax lethal toxin is a two-component toxin consisting of protective antigen (PrAg), the cell binding and translocation domain, and lethal factor (LF), the catalytic domain, which cleaves all mitogen-activated ...
Sensitivity of acute myeloid leukemia cells to the dual targeting of the urokinase plasminogen activator and the MAPK pathway by a urokinase-activated anthrax lethal toxin. (c2013)

Bekdash, Amira (Lebanese American University, 2013-09-03)

Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by abnormal proliferation of myeloid progenitor cells. Around 15,000 new case of AML are diagnosed each year with a fatality rate of 65%. Conventional ...
Targeting human acute myeloid leukemia cells using human recombinant arginase I (Co) - PEG5000 [HuArgl (Co) - PEG5000] - induced arginine depletion. (c2013)

Tanios, Rita Farid (Lebanese American University, 2015-02-10)

Acute myeloid leukemia (AML) is the most common leukemia in adults. With current chemotherapy protocols, patients have poor prognosis and more than 10,000 patients die yearly of AML. Therefore new treatment to improve ...
Targeting the MAP Kinase pathway in human acute myeloid leukemia cells using a recombinant anthrax lethal toxin. (c2013)

Kassab, Elias (Lebanese American University, 2013-09-03)

In this study, we attempt to target the mitogen-activated protein kinase (MAPK) pathway in acute myeloid leukemia (AML) cells using a recombinant anthrax lethal toxin (LeTx). Around 15,000 new case of Acute Myeloid Leukemia ...

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