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Browsing by Author "Youhanna, Sonia"

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Browsing by Author "Youhanna, Sonia"

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  • Association of hypertension with coronary artery disease onset in the Lebanese population 
    Milane, Aline; Abdallah, Jad; Kanbar, Roy; Khazen, Georges; Saad, Aline; Ghassibe-Sabbagh, Michella; Salloum, Angelique K.; Youhanna, Sonia; Saad, Aline; El Bayeh, Hamid; Chammas, Elie; Platt, Daniel E.; Hager, Jorg; Gauguier, Dominique; Zalloua, Pierre (2017-04-11)
    The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension ...
  • Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography 
    Deeb, Mary E.; Khazen, Georges; Zalloua, Pierre A.; Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Cazier, Jean-Baptiste; Kamatani, Yoichiro; Salloum, Angelique K.; Hager, Jo¨rg; Youhanna, Sonia (2016-11-23)
    A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk ...
  • Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk 
    Milane, Aline; Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Youhanna, Sonia; Abchee, Antoine B.; Haber, Marc; Badro, Danielle A.; Salloum, Angelique K.; Douayhi, Bouchra; Nemr, Rita; Cazier, Jean-Baptiste; Zalloua, Pierre A. (2016-10-05)
    Background Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims The rationale behind this study is to explore the correlation between degree and site of coronary lesion ...
  • Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis 
    Hager, Jorg; Kamatani, Yoichiro; Cazier, Jean-Baptiste; Youhanna, Sonia; Ghassibe-Sabbagh, Michella; Platt, Daniel E.; Abchee, Antoine B.; Romanos, Jihane; Khazen, Georges; Othman, Raed; Badro, Danielle A.; Haber, Marc; Salloum, Angelique K.; Zalloua, Pierre A. (2016-03-17)
    The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide ...
  • The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease 
    Abchee, Antoine; El-Sibai, Mirvat; Youhanna, Sonia; Yeretzian, Joumana S.; Hanine, Estephan; Makhoul, Nadine J.; Puzantian, Houry; Sawaya, Jaber; Nasrallah, Antoine; Rebeiz, Abdallah G.; Zreik, Tony G.; Azar, Sami T.; Zalloua, Pierre A. (2017-07-27)
    Background: Mutations in genes regulating lipid metabolism, vasoactivity, and coagulation are important modulators of coronary artery disease (CAD). Objective: This study investigated the association between allelic ...
  • Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk 
    Merhi, Mahmoud; Demirdjian, Sally; Hariri, Essa; Sabbah, Nada; Youhanna, Sonia; Ghassibe-Sabbagh, Michella; Naoum, Joseph; Haber, Marc; Kanbar, Roy; Zalloua, Pierre; Khazen, Georges (2016-03-17)
    Background The role of inflammation in coronary artery disease (CAD) pathogenesis is well recognized. Moreover, smoking inhalation increases the activity of inflammatory mediators through an increase in leukotriene synthesis ...
  • Large scale association analysis identifies three susceptibility loci for coronary artery disease 
    El-Khazen, Georges; Zalloua, Pierre A.; Saade, Stephanie; Cazier, Jean-Baptiste; Ghassibe-Sabbagh, Michella; Youhanna, Sonia; Badro, Danielle A.; Kamatani, Yoichiro (2016-03-17)
    Genome wide association studies (GWAS) and their replications that have associated DNA variants with myocardial infarction (MI) and/or coronary artery disease (CAD) are predominantly based on populations of European or ...
  • Parental consanguinity and family history of coronary artery disease strongly predict early stenosis 
    Deeb, Mary E.; Zreik, Tony G.; Zalloua, Pierre; Youhanna, Sonia; Platt, Daniel E.; Rebeiz, Abdallah; Lauridsen, Michael; Nasrallah, Antoine; Alam, Samir; Puzantian, Houry; Kabbani, Samer (2016-11-18)
    Background Coronary artery disease (CAD) is a multifactorial disease with acquired and inherited components. Aim We investigated the roles of family history and consanguinity on CAD risk and age at diagnosis in ...