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Browsing by Author "Xian, Lingling"

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Genetic engineering of primary mouse intestinal organoids using magnetic nanoparticle transduction viral vectors for frozen sectioning

Xian, Lingling; Chia, Lionel; Georgess, Dan; Shuai, Shuai; Ewald, Andrew J.; Resar, Linda M.S. (2019-09-20)

We describe step-by-step instructions to: 1) efficiently engineer intestinal organoids using magnetic nanoparticles for lenti- or retroviral transduction, and, 2) generate frozen sections from engineered organoids. This ...
HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

Georgess, Dan; Xian, Lingling; Huso, Tait; Cope, Leslie; Belton, Amy; Chang, Yu-ting (2019-04-04)

High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. Prior studies showed that Hmga1 drives hyperproliferation, ...

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