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Browsing by Author "Vauthey, Nicolas"

LAUR Repository

Browsing by Author "Vauthey, Nicolas"

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  • Bevacizumab Improves Pathologic Response and Protects Against Hepatic Injury in Patients Treated With Oxaliplatin-Based Chemotherapy for Colorectal Liver Metastases 
    Ribero, David; Wang, Huamin; Donadon, Matteo; Zorzi, Daria; Thomas, Melanie; Eng, Cathy; Chang, David; Curley, Steven; Abdalla, Eddie; Ellis, Lee; Vauthey, Nicolas (2015-11-16)
    BACKGROUND. The current study evaluated the effect of bevacizumab added to fluoropyrimidine-plus-oxaliplatin (5FU/OX) chemotherapy for colorectal liver metastases (CLM) on the pathologic response and nontumorous liver ...
  • Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli 
    Abdalla, Eddie; Su, Li-Kuo; Law, Calvin; Kohlmann, Wendy; Rashid, Asif; Vauthey, Nicolas (2015-11-10)
    BACKGROUND Certain primary hepatic tumors have been associated with familial adenomatous polyposis (FAP), a condition caused by germline mutations of the adenomatous polyposis coli (APC) gene. However, a genetic association ...
  • Body surface area and body weight predict total liver volume in Western adults 
    Abdalla, Eddie; Vauthey, Nicolas; Doherty, Dorota; Gertsch, Philippe; Fenstermacher, Marc; Loyer, Evelyne; Leurt, Jan; Materne, Roland; Wang, Xuemei; Encarnacion, Arthur; Herron, Delise; Mathey, Christian; Ferrari, Giovanni; Charnsangavej, Chusilp; Do, Kim-Anh; Denys, Alban (2015-11-10)
    Computed tomography (CT) is used increasingly to measure liver volume in patients undergoing evaluation for transplantation or resection. This study is designed to determine a formula predicting total liver volume (TLV) ...
  • Chemotherapy prior to Hepatic Resection for Colorectal Liver Metastases 
    Vauthey, Nicolas; Abdalla, Eddie (2015-11-16)
    Background: Improved efficacy of chemotherapy for treatment of colorectal liver metastases (CLM) has renewed interest in the use of systemic treatment as part of a ‘potentially curative’ treatment plan for patients with ...
  • Chemotherapy Regimen Predicts Steatohepatitis and an Increase in 90-Day Mortality After Surgery for Hepatic Colorectal Metastases 
    Vauthey, Nicolas; Pawlik, Timothy; Ribero, Dario; Wu, Tsung-Teh; Zorzi, Daria; Hoff, Paulo; Xiong, Henry; Eng, Cathy; Lauwers, Gregory; Mino-Kenudson, Mari; Risio, Mauro; Muratore, Andrea; Capussotti, Lorenzo; Curley, Steven; Abdalla, Eddie (2015-11-12)
    Purpose Chemotherapy before resection of hepatic colorectal metastases (CRM) may cause hepatic injury and affect postoperative outcome. Patients and Methods Four hundred six patients underwent hepatic resection of CRM ...
  • Comparison between hepatic wedge resection and anatomic resection for colorectal liver metastases 
    Abdalla, Eddie; Zorzi, Daria; Mullen, John; Pawlik, Timothy; Andres, Axel; Muratore, Andrea; Curley, Steven; Mentha, Gilles; Capussotti, Lorenzo; Vauthey, Nicolas (2015-11-12)
    Some investigators have suggested that wedge resection (WR) confers a higher incidence of positive margins and an inferior survival compared with anatomic resection (AR) of colorectal liver metastases (CLM). We sought to ...
  • Comparison of CT Methods for Determining the Fat Content of the Liver 
    Kodama, Yoshihisa; Ng, Chaan; Wu, Tsung-T; Ayers, Gregory; Curley, Steven; Abdalla, Eddie; Vauthey, Nicolas; Chamsangavej, Chulsip (2015-11-16)
    OBJECTIVE. The purpose of this study was to assess which of a number of methods of measuring attenuation on CT scans is best for prediction of hepatic fat content. MATERIALS AND METHODS. This retrospective study was ...
  • Comparison of Two Methods of Future Liver Remnant Volume Measurement 
    Shin Chun, Yun; Ribero, Dario; Abdalla, Eddie; Madoff, David; Mortenson, Melinda; Wei, Steven; Vauthey, Nicolas (2015-11-17)
    Background In liver transplantation, a minimum graft to patient body weight (BW) ratio is required for graft survival; in liver resection, total liver volume (TLV) calculated from body surface area (BSA) is used to determine ...
  • Critical Appraisal of the Clinical and Pathologic Predictors of Survival After Resection of Large Hepatocellular Carcinoma 
    Abdalla, Eddie; Pawlik, Timothy; Poon, Ronnie; Zorzi, Daria; Ikai, Iwao; Curley, Steven; Nagorney, David; Belghiti, Jacques; Oi-Lin Ng, Irene; Yamaoka, Yoshio; Lauwers, Gregory; Vauthey, Nicolas (2015-11-11)
    Hypothesis A subset of patients with hepatocellular carcinoma (HCC) with a diameter of 10 cm or larger may benefit from hepatic resection. Design Retrospective study of a multi-institutional database. Setting Five ...
  • Debunking dogma 
    Abdalla, Eddie; Pawlik, Timothy; Vauthey, Nicolas; Curley, Steven (2015-11-12)
    Treatment of four or more colorectal liver metastases (CRLMs) is controversial and remains a relative contraindication to surgery at some institutions. We sought to assess the outcome of patients with four or more CRLMs ...
  • Delayed Recovery after Pancreaticoduodenectomy 
    Abdalla, Eddie; Aloia, Thomas; Lee, Jeffrey; Vauthey, Nicolas; Wolff, Robert; Varadhachary, Gauri; Abbruzzese, James; Crane, Christopher; Evans, Douglas; Pisters, Peter (2015-11-12)
    Background Delayed recovery after pancreaticoduodenectomy (PD) is believed to preclude adjuvant therapy for approximately 30% of patients who undergo elective PD as initial treatment for pancreatic adenocarcinoma. This ...
  • Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients 
    Curley, Steven; Marra, Paolo; Beaty, Karen; Vauthey, Nicolas; Abdalla, Eddie; Scaife, Courtney; Raut, Chan; Wolff, Robert; Choi, Haesun; Loyer, Evelyne; Vallone, Paolo; Fiore, Francesco; Scordino, Fabrizio; Di Rosa, Vincenzo; Orlando, Raffaele; Pignata, Sandro; Daniele, Bruno; Izzo, Francesco (2015-11-10)
    Background: Radiofrequency ablation (RFA) has become a common treatment of patients with unresectable primary and secondary hepatic malignancies. We performed this prospective analysis to determine early (within 30 days) ...
  • Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women 
    Hassan, Manal; Spitz, Margaret; Thomas, Melanie; El-Deeb, Adel; Glover, Katrina; Nguyem, Nga; Chan, Wenyaw; Kaseb, Ahmed; Curley, Steven; Vauthey, Nicolas; Ellis, Lee; Abdalla, Eddie; Lozano, Richard; Patt, Yehuda; Brown, Thomas; Abbruzzese, James; Li, Donghui (2015-11-17)
    The International Agency for Research on Cancer has declared smoking to be a risk factor for hepatocellular carcinoma (HCC). However, passive exposure to cigarette smoke and use of noncigarette tobacco products on the risk ...
  • Effect of Surgical Margin Status on Survival and Site of Recurrence After Hepatic Resection for Colorectal Metastases 
    Pawlik, Timothy; Scoggins, Charles; Zorzi, Daria; Abdalla, Eddie; Andres, Axel; Eng, Cathy; Curley, Steven; Loyer, Evelyne; Muratore, Andrea; Mentha, Gilles; Capussotti, Lorenzo; Vauthey, Nicolas (2015-11-11)
    Objective: To evaluate the influence of surgical margin status on survival and site of recurrence in patients treated with hepatic resection for colorectal metastases. Methods: Using a multicenter database, 557 ...
  • Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization 
    Abdalla, Eddie; Barnett, Carlton; Doherty, Dorota; Curley, Steven; Vauthey, Nicolas (2015-11-10)
    Hypothesis Preoperative portal vein embolization (PVE) allows potentially curative hepatic resection without additional morbidity or mortality in patients with hepatobiliary malignancies who are marginal candidates for ...
  • Extrahepatic Bile Duct Adenocarcinoma 
    Borghero, Yerko; Crane, Christopher; Szklaruk, Janio; Oyarzo, Mauricio; Curley, Steven; Pisters, Peter; Evans, Douglas; Abdalla, Eddie; Thomas, Melanie; Das, Prajnan; Wistuba, Ignacio; Krishnan, Sunil; Vauthey, Nicolas (2015-11-16)
    Background Patients with resected extrahepatic bile duct adenocarcinoma who have microscopically positive resection margins and/or pathologic locoregional nodal involvement (R1pN1) have a high-risk of locoregional recurrence, ...
  • Hepatic Insufficiency and Mortality in 1,059 Noncirrhotic Patients Undergoing Major Hepatectomy 
    Mullen, John; Ribero, Dario; Reddy, Srinevas; Donadon, Matteo; Zorzi, Daria; Gautam, Shiva; Abdalla, Eddie; Curley, Steven; Capussotti, Lorenzo; Clary, Bryan; Vauthey, Nicolas (2015-11-16)
    Background To establish a reliable definition of postoperative hepatic insufficiency (PHI) in noncirrhotic patients undergoing major hepatectomy. No standard definition of PHI has been established, but one is essential ...
  • Hepatic Resection for Metastatic Melanoma 
    Abdalla, Eddie; Pawlik, Timothy; Zorzi, Daria; Clary, Bryan; Gershenwald, Jeffrey; Ross, Merrick; Aloia, Thomas; Curley, Steven; Camacho, Luis; Capussotti, Lorenzo; Elias, Dominique; Vauthey, Nicolas (2015-11-12)
    Background Resection of melanoma metastatic to the liver remains controversial. We evaluated the efficacy of hepatic resection in patients with metastatic ocular and cutaneous melanoma and assessed factors that could ...
  • Hepatitis serology predicts tumor and liver-disease characteristics but not prognosis after resection of hepatocellular carcinoma 
    Abdalla, Eddie; Pawlik, Timothy; Poon, Ronnie; Sarmiento, Juan; Lkai, Iwao; Curley, Steven; Nagorney, David; Belghiti, Jacques; Oi-Lin Ng, Irene; Yamaoka, Yoshio; Lauwers, Gregory; Vauthey, Nicolas (2015-11-10)
    The impact of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection on survival rates after resection of hepatocellular carcinoma (HCC) is controversial. The objective of this study was to determine whether serologic ...
  • High-resolution computed tomography accurately predicts resectability in hilar cholangiocarcinoma 
    Aloia, Thomas; Chamsangavej, Chulsip; Faria, Silvana; Ribero, Dario; Abdalla, Eddie; Vauthey, Nicolas; Curley, Steven (2015-11-12)
    Introduction Despite the use of radiologic, endoscopic, and laparoscopic staging techniques, the rate of nontherapeutic laparotomies in patients with hilar cholangiocarcinoma remains high. This study evaluated the ...