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Browsing by Author "Slim, Rima"

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Browsing by Author "Slim, Rima"

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  • Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation 
    El Maarri, Osman; Djuric, Ugljesa; Lamb, Barbara; Kuick, Rork; Seoud, Muheiddine; Coullin, Philippe; Oldenburg, Johannes; Hanash, Samir; Slim, Rima (2017-09-13)
    An imprinting disorder has been believed to underlie the etiology of familial biparental hydatidiform moles (HMs) based on the abnormal methylation or expression of imprinted genes in molar tissues. However, the extent of ...
  • Maternal alleles acquiring paternal methylation patterns in biparental complete hydatidiform mole 
    El Maarri, Osman; Seoud, Muhieddine; Coullin, Philippe; Herbiniaux, Ursula; Oldenburg, Johannes; Rouleau, Guy; Slim, Rima (2017-09-12)
    We previously mapped a maternal locus responsible for biparental complete hydatidiform moles (BiCHMs) to 19q13.4. The two index patients had a total of 14 molar pregnancies, eight abortions at various developmental stages, ...
  • NLRP7 inter-domain interactions 
    El Maarri, Osman; Singer, Heike; Biswas, Arijit; Zimmer, Nicole; Messaed, Christiane; Oldenburg, Johannes; Slim, Rima (2017-09-15)
    Mutations in NLRP7 (NOD-like-receptor family, pyrin domain containing 7) are responsible for a type of recurrent pregnancy loss known as recurrent hydatidiform mole (HYDM1). This condition is characterized by abnormal ...
  • Patients with familial biparental hydatidiform moles have normal methylation at imprinted genes 
    El Maarri, Osman; Seoud, Muhieddine; Riviere, Jean-Baptiste; Oldenburg, Johannes; Walter, Jorn; Rouleau, Guy; Slim, Rima (2017-09-13)
    In molar tissues from patients with recurrent biparental hydatidiform moles, we could previously demonstrate that differentially methylated regions (DMRs) of four imprinted genes are abnormally methylated on the maternal ...