Anthrax lethal toxin (LeTx), secreted by Bacillus anthracis, consists of protective antigen (PrAg) and lethal factor (LF). Following binding to its ubiquitously expressed cell surface receptors tumor endothelium marker 8 ...

Native proaerolysin is a channel-forming bacterial protoxin that binds to cell-surface receptors and then is activated by furin or furin-like proteases. We genetically engineered proaerolysin by replacing the furin-cleavage ...

Urokinase plasminogen activator (uPA) is a tumor-specific protease highly expressed in several types of solid tumors and rarely present on normal cells under physiologic conditions. Due to its high expression on metastatic ...