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Browsing by Author "Sarmiento, Corina"

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Browsing by Author "Sarmiento, Corina"

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  • Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells 
    El-Sibai, Mirvat; Nalbant, Peri; Pang, Huan; Flinn, Rory J.; Sarmiento, Corina; Macaluso, Frank; Cammer, Michael; Condeelis, John S.; Hahn, Klaus M.; Backer, Jonathan M. (2015-11-09)
    Cdc42 plays a central role in regulating the actin cytoskeleton and maintaining cell polarity. Here, we show that Cdc42 is crucial for epidermal growth factor (EGF)- stimulated protrusion in MTLn3 carcinoma cells. ...
  • Cofilin determines the migration behavior and turning frequency of metastatic cancer cells 
    Sidani, Mazen; Wessels, Deborah; Mouneimne, Ghassan; Ghosh, Mousumi; Goswami, Sumanta; Sarmiento, Corina; Wang, Weigang; Kuhl, Spencer; El-Sibai, Mirvat; Backer, Jonathan M.; Eddy, Robert; Soll, David; Condeelis, John (2015-11-09)
    We have investigated the effects of inhibiting the expression of cofilin to understand its role in protrusion dynamics in metastatic tumor cells, in particular. We show that the suppression of cofilin expression in MTLn3 ...
  • WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells 
    Sarmiento, Corina; Wang, Weigang; Dovas, Athanassios; Yamaguchi, Hideki; Sidani, Mazen; El-Sibai, Mirvat; Desmarais, Vera; Holman, Holly A.; Kitchen, Susan; Backer, Jonathan M.; Alberts, Art; Condeelis, John (2017-02-08)
    We examined the role of the actin nucleation promoters neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE2 in cell protrusion in response to epidermal growth factor (EGF), a key regulator in carcinoma cell invasion. ...