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Browsing by Author "Ratan, Rajiv R."

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Histone deacetylase inhibitors and mithramycin a impact a similar neuroprotective pathway at a crossroad between cancer and neurodegeneration

Sleiman, Sama F.; Berlin, Jill; Basso, Manuela; Karuppagounder, Saravanan S.; Rohr, Jurgen; Ratan, Rajiv R. (2017-10-12)

Mithramycin A (MTM) and histone deacetylase inhibitors (HDACi) are effective therapeutic agents for cancer and neurodegenerative diseases. MTM is a FDA approved aureolic acid-type antibiotic that binds to GC-rich DNA ...
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease

Sleiman, Sama F.; Mashishi, Lata; Coppola, Giovanni; Thompson, Leslie M.; Ratan, Rajiv R.; Starkov, Anatoly; Antonyak, Marc A. (2017-09-06)

Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads to striatal degeneration via the transcriptional dysregulation of a number of genes, including those involved in mitochondrial ...
Looking above but not beyond the genome for therapeutics in neurology and psychiatry

Sleiman, Sama; Ratan, Rajiv R.; Basso, Manuela (2017-09-05)

We welcome you to a special issue of Neurotherapeutics that highlights much of the exciting new thinking behind a burgeoning and therapeutically relevant topic—epigenetic proteins in psychiatric and neurological disease. ...
Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration

Sleiman, Sama F.; Langley, Brett C.; Berlin, Jill; Xia, Li; Payappilly, Jimmy B.; Kharel, Madan K.; Guo, Hengchang; Thonpson, Leslie Michels; Mahishi, Lata; Ahuja, Preeti; Maclellan, W. Robb; Geschwind, Daniel H.; Coppola, Giovanni; Rohr, Jurgen; Ratan, Rajiv R. (2017-10-12)

Oncogenic transformation of postmitotic neurons triggers cell death, but the identity of genes critical for degeneration remain unclear. The antitumor antibiotic mithramycin prolongs survival of mouse models of Huntington's ...
Putting the ‘HAT’ back on survival signalling

Sleiman, Sama F.; Basso, Manuela; Mashishi, Lata; Kozikowski, Alan P.; Donohoe, Mary E.; Langley, Brett; Ratan, Rajiv R. (2017-09-06)

Decreased histone acetyltransferase activity and transcriptional dysfunction have been implicated in almost all neurodegenerative conditions. Increasing net histone acetyltransferase activity through inhibition of the ...
Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation

Sleiman, Sama F.; Basso, Manuela; Xia, Li; Berlin, Jill; Ko, Brendan; Haskew-Layton, Renee; Kim, Eunhee; Antonyak, Marc A.; Cerione, Richard A.; Lismaa, Siri E.; Willis, Dianna; Cho, Sunghee; Ratan, Rajiv R. (2017-04-11)

Molecular deletion of transglutaminase 2 (TG2) has been shown to improve function and survival in a host of neurological conditions including stroke, Huntington's disease, and Parkinson's disease. However, unifying schemes ...

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