Purpose: The incidence of regulatory T cells (Treg) in intrinsic central nervous system malignancies is unknown. Immunotherapeutic approaches that inhibit the Treg population may be limited to a subset of patients with ...

Purpose: Activation of signal transducers and activators of transcription 3 (STAT3) has been identified as a central mediator of melanoma growth and metastasis. We hypothesized that WP1066, a novel STAT3 blockade agent, ...

Melanoma is a common and deadly tumor that upon metastasis to the brain, survival is less than one year. Development of new, effective therapies for metastatic melanoma that target novel pathways associated with the genesis ...