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Browsing by Author "Platt, Daniel E."

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Browsing by Author "Platt, Daniel E."

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  • Afghanistan's ethnic groups share a Y-chromosomal heritage structured by historical events 
    Haber, Marc; Platt, Daniel E.; Bonab, Maziar Ashrafian; Youhanna, Sonia C.; Soria-Hernanz, David F.; Martínez-Cruz, Begona; Douaihy, Bouchra; Ghassibe-Sabbagh, Michella; Rafatpanah, Hoshang; Ghanbari, Mohsen; Whale, John; Balanovsky, Oleg; Spencer Wells, R.; Comas, David; Tyler-Smith, Chris; Zalloua, Pierre A. (2019-07-25)
    Afghanistan has held a strategic position throughout history. It has been inhabited since the Paleolithic and later became a crossroad for expanding civilizations and empires. Afghanistan's location, history, and diverse ...
  • ALOX5AP gene variants show differential association with coronary artery disease in different populations 
    Alwan, Ahmad; Youhanna, Sonia C.; Platt, Daniel E.; El-Sibai, Mirvat; Yerezian, Joumana S.; Deeb, Mary E.; Khazen, Georges; Saade, Stephanie; Zreik, Tony G.; El Bayeh, Hamid; Maalouf, Assaad; Zalloua, Pierre A.; Abchee, Antoine (2015-12-17)
    Coronary artery disease (CAD) is a complex disease with various components, genetic as well as environmental. Previous reports correlating ALOX5AP gene variants and CAD showed conflicting results depending on the population ...
  • Association of hypertension with coronary artery disease onset in the Lebanese population 
    Milane, Aline; Abdallah, Jad; Kanbar, Roy; Khazen, Georges; Saad, Aline; Ghassibe-Sabbagh, Michella; Salloum, Angelique K.; Youhanna, Sonia; Saad, Aline; El Bayeh, Hamid; Chammas, Elie; Platt, Daniel E.; Hager, Jorg; Gauguier, Dominique; Zalloua, Pierre (2017-04-11)
    The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension ...
  • Association of waterpipe smoking with myocardial infarction and determinants of metabolic syndrome among catheterized patients 
    Platt, Daniel E.; Hariri, Essa; Salameh, Pascale; Helou, Mariana; Sabbah, Nada; Merhi, Mahmoud; Abchee, Antoine B.; Zalloua, Pierre A. (2019-06-03)
    Background: Waterpipe smoking is a rising global public health epidemic perceived by many users to be less harmful, though its toxicity overlaps or even exceeds that of cigarette smoking. Short-term cardiovascular changes ...
  • Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography 
    Deeb, Mary E.; Khazen, Georges; Zalloua, Pierre A.; Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Cazier, Jean-Baptiste; Kamatani, Yoichiro; Salloum, Angelique K.; Hager, Jo¨rg; Youhanna, Sonia (2016-11-23)
    A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk ...
  • Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk 
    Milane, Aline; Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Youhanna, Sonia; Abchee, Antoine B.; Haber, Marc; Badro, Danielle A.; Salloum, Angelique K.; Douayhi, Bouchra; Nemr, Rita; Cazier, Jean-Baptiste; Zalloua, Pierre A. (2016-10-05)
    Background Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims The rationale behind this study is to explore the correlation between degree and site of coronary lesion ...
  • Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis 
    Hager, Jorg; Kamatani, Yoichiro; Cazier, Jean-Baptiste; Youhanna, Sonia; Ghassibe-Sabbagh, Michella; Platt, Daniel E.; Abchee, Antoine B.; Romanos, Jihane; Khazen, Georges; Othman, Raed; Badro, Danielle A.; Haber, Marc; Salloum, Angelique K.; Zalloua, Pierre A. (2016-03-17)
    The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide ...
  • Geographical Structure of the Y-chromosomal Genetic Landscape of the Levant 
    El-Sibai, Mirvat; Platt, Daniel E.; Haber, Marc; Xue, Yali; Youhanna, Sonia C.; Wells, R. Spencer; Izaabel, Hassan; Sanyoura, May F.; Harmanani, Haidar; Bonab, Maziar Ashrafian; Behbehani, Jaafar; Hashwa, Fuad; Tyler-Smith, Chris; Zalloua, Pierre A.; The Genographic Consortium (2015-11-04)
    We have examined the male-specific phylogeography of the Levant and its surroundings by analyzing Y-chromosomal haplogroup distributions using 5874 samples (885 new) from 23 countries. The diversity within some of these ...
  • Identifying genetic traces of historical expansions 
    Zalloua, Pierre A.; Platt, Daniel E.; El Sibai, Mirvat; Khalife, Jade; Makhoul, Nadine; Haber, Marc; Xue, Yali; Izaabel, Hassan; Bosch, Elena; Adams, Susan M.; Arroyo, Eduardo; Lopez-Parra, Ana Maria; Aler, Mercedes; Picornell, Antonia; Ramon, Misericordia; Jobling, Mark A.; Comas, David; Bertranpetit, Jaume; Tyler-Smith, Chris (2019-07-18)
    The Phoenicians were the dominant traders in the Mediterranean Sea two thousand to three thousand years ago and expanded from their homeland in the Levant to establish colonies and trading posts throughout the Mediterranean, ...
  • Influences of history, geography, and religion on genetic structure 
    Haber, Marc; Platt, Daniel E.; Badro, Danielle A.; Xue, Yali; El-Sibai, Mirvat; Bonab, Maziar Ashrafian; Youhanna, Sonia C.; Saade, Stephanie; Soria-Hernanz, David F.; Royyuru, Ajay; Wells, R. Spencer; Tyler-Smith, Chris; Zalloua, Pierre A. (2017-08-10)
    Cultural expansions, including of religions, frequently leave genetic traces of differentiation and in-migration. These expansions may be driven by complex doctrinal differentiation, together with major population migrations ...
  • Mapping post-glacial expansions 
    Khazen, Georges; Zalloua, Pierre A.; Platt, Daniel E.; Dagher- Kharrat, Magda Bou; Douaihy, Bouchra; Bonab, Maziar Ashrafian; Salloum, Angelique; Mouzaya, Francis; Luiselli, Donata; Tyler-Smith, Chris; Renfrew, Colin; Matisoo-Smith, Elizabeth (2017-04-25)
    Archaeological, palaeontological and geological evidence shows that post-glacial warming released human populations from their various climate-bound refugia. Yet specific connections between these refugia and the timing ...
  • mtDNA lineages reveal coronary artery disease‐associated structures in the Lebanese population 
    Haber, Marc; Youhanna, Sonia C.; Balanovsky, Oleg; Saade, Stephanie; Martínez‐Cruz, Begona; Ghassibe-Sabbagh, Michella; Shasha, Nabil; Osman, Raed; El Bayeh, Hamid; Koshel, Sergey; Zaporozhchenko, Valery; Balanovska, Elena; Soria‐Hernanz, David F.; Platt, Daniel E. (2019-07-22)
    Population origins and ancestry have previously been found to be important determinants of coronary artery disease (CAD). This study investigates associations of Lebanese mitochondrial DNA lineages with CAD and studies ...
  • Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population 
    Ghassibe-Sabbagh, Michella; Deeb, Mary; Saloum, Angelique K.; Hirbli, Kamal; Ahdab, Rechdi; Zalloua, Pierre A.; Nemr, Rita; Mouzaya, Francis; Chami, Youssef; Akle, Yasmine; Platt, Daniel E. (2016-06-14)
    Background: The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, ...
  • Parental consanguinity and family history of coronary artery disease strongly predict early stenosis 
    Deeb, Mary E.; Zreik, Tony G.; Zalloua, Pierre; Youhanna, Sonia; Platt, Daniel E.; Rebeiz, Abdallah; Lauridsen, Michael; Nasrallah, Antoine; Alam, Samir; Puzantian, Houry; Kabbani, Samer (2016-11-18)
    Background Coronary artery disease (CAD) is a multifactorial disease with acquired and inherited components. Aim We investigated the roles of family history and consanguinity on CAD risk and age at diagnosis in ...
  • T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility 
    Hirbli, Kamal; Zalloua, Pierre A.; Ghassibe-Sabbagh, Michela; Haber, Marc; Salloum, Angelique K.; Al-Sarraj, Yasser; Akle, Yasmine; Romanos, Jihane; Mouzaya, Francis; Gaugier, Dominique; Platt, Daniel E.; El Shanti, Hatem (2019-02-27)
    Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the ...
  • Type II diabetes mellitus and hyperhomocysteinemia 
    Platt, Daniel E.; Hariri, Essa; Salameh, Pascale; Merhi, Mahmoud; Sabbah, Nada; Helou, Mariana; Mouzaya, Francis; Nemr, Rita; Al-Sarraj, Yasser; El-Shanti, Hatem; Abchee, Antoine B.; Zalloua, Pierre A. (2019-06-03)
    Background Elevated homocysteine (Hc) levels have a well-established and clear causal relationship to epithelial damage leading to coronary artery disease. Furthermore, it is strongly associated with other metabolic ...
  • Y-chromosomal diversity in Lebanon is structured by recent historical events 
    Zalloua, Pierre A.; Xue, Yali; Khalife, Jade; Makhoul, Nadine; Debiane, Labib; Platt, Daniel E.; Royyuru, Aya K.; Herrera, Rene J.; Hernanz, David F. Soria; Blue-Smith, Jason; Wells, R. Spencer; Comas, David; Bertranpetit, Jaune; Tyler-Smith, Chris (2019-07-18)
    Lebanon is an eastern Mediterranean country inhabited by approximately four million people with a wide variety of ethnicities and religions, including Muslim, Christian, and Druze. In the present study, 926 Lebanese men ...
  • Y-chromosome R-M343 African lineages and sickle cell disease reveal structured assimilation in Lebanon 
    Haber, Marc; Platt, Daniel E.; Khoury, Simon; Badro, Danielle A.; Abboud, Miguel; Tyler-Smith, Chris; Zalloua, Pierre (2019-07-22)
    We have sought to identify signals of assimilation of African male lines in Lebanon by exploring the association of sickle cell disease (SCD) in Lebanon with Y-chromosome haplogroups that are informative of the disease ...