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Browsing by Author "Naim, Hassan Y."

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Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions

Rizk, Sandra; Behrendt, Marc; Krahn, Micheal P.; Al-Bayati, Hiam; Amiri, Mahdi; Naim, Hassan Y. (2015-10-27)

Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 ...
Cellular and Molecular Adaptation of Arabian Camel to Heat Stress

Hoter, Abdullah; Rizk, Sandra; Naim, Hassan Y. (2019-12-03)

To cope with the extreme heat stress and drought of the desert, the Arabian camel (Camelus dromedarius) has developed exceptional physiological and biochemical particularities. Previous reports focused mainly on the ...
Dextran Sodium Sulfate-Induced Impairment of Protein Trafficking and Alterations in Membrane Composition in Intestinal Caco-2 Cell Line

Toutounji, Mohamad; Wanes, Dalanda; El-Harakeh, Mohammad; El-Sabban, Marwan; Rizk, Sandra; Naim, Hassan Y. (2020-07-15)

A key morphological feature of inflammatory bowel disease (IBD) is the loss of the barrier function of intestinal epithelial cells. The present study investigates endoplasmic reticulum (ER) stress in addition to alterations ...
Different Niemann-Pick C1 Genotypes Generate Protein Phenotypes that Vary in their Intracellular Processing, Trafficking and Localization

Shammas, Hadeel; Kuech, Eva-Maria; Rizk, Sandra; Das, Anibh M.; Naim, Hassan Y. (2019-09-20)

Niemann-Pick Type C (NP-C) is an inherited neurovisceral lysosomal storage disease characterized by a defect in the trafficking of endocytosed cholesterol. In 95% of patients the gene encoding NPC1 is affected. The correlation ...
Different Trafficking Phenotypes of Niemann-Pick C1 Gene Mutations Correlate with Various Alterations in Lipid Storage, Membrane Composition and Miglustat Amenability

Brogden, Graham; Shammas, Hadeel; Walters, Friederike; Maalouf, Katia; Das, Anibh M.; Naim, Hassan Y.; Rizk, Sandra (2020-07-15)

Niemann-Pick Type C (NPC) is an autosomal recessive lysosomal storage disease leading to progressive neurodegeneration. Mutations in the NPC1 gene, which accounts for 95% of the cases, lead to a defect in intra-lysosomal ...
Heat Shock Protein 60 in Hepatocellular Carcinoma

Hoter, Abdullah; Rizk, Sandra; Naim, Hassan Y. (2020-07-22)

Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial ...
A modified lipid composition in Fabry disease leads to an intracellular block of the detergent-resistant membrane-associated dipeptidyl peptidase IV

Rizk, Sandra; Maalouf, Katia; Jia, Jia; Brogden, Graham; Keiser, Markus; Das, Anibh; Naim, Hassan Y. (2016-05-13)

Fabry disease is an X-linked lysosomal storage disorder that leads to abnormal accumulation of glycosphingolipids due to a deficiency of alpha-galactosidase A (AGAL). The consequences of these alterations on the targeting ...
The multiple roles and therapeutic potential of molecular chaperones in prostate cancer

Hoter, Abdullah; Rizk, Sandra; Naim, Hassan Y. (2019-12-05)

Prostate cancer (PCa) is one of the most common cancer types in men worldwide. Heat shock proteins (HSPs) are molecular chaperones that are widely implicated in the pathogenesis, diagnosis, prognosis, and treatment of many ...
Protocadherin of the liver, kidney and colon associates with detergent-resistant membranes during cellular differentiation

Rizk, Sandra; Alfalah, Marwan; Krahn, Micheal P.; Behrendt, Marc; Naim, Hassan Y. (2015-10-26)

Protocadherin LKC (PLKC) is a member of the heterogeneous subgroup of protocadherins that was identified and described as a potential tumor-suppressor gene involved in contact inhibition (Okazaki, N., Takahashi, N., Kojima, ...
The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines

Ghanem, Paola; Zouein, Annalise; Mohamad, Maya; Hodroj, Mohammad H.; Haykal, Tony; Najem, Sonia Abou; Naim, Hassan Y.; Rizk, Sandra (2020-07-24)

Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an ...

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