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Browsing by Author "Mroueh, Mohamad A."

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Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways

Daaboul, Hamid E.; Daher, Costantine F.; Bodman-Smith, Kikki; Taleb, Robin I.; Shehaby, Wassim N.; Boulos, Joelle; Dagher, Carole; Mroueh, Mohamad A.; El-Sibai, Mirvat (2017-12-15)

Previous studies in our laboratory showed that Daucus carota oil extract (DCOE) possesses in vitro and in vivo anticancer activities. Chemical analysis of DCOE led to the isolation of β-2-himachalen-6-ol (HC) which exhibited ...
The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis

Daaboul, Hamid E.; Dagher, Carole; Taleb, Robin I.; Bodman-Smith, Kikki; Shebaby, Wassim N.; El-Sibai, Mirvat; Mroueh, Mohamad A.; Daher, Costantine F. (2019-10-08)

β-2-himachalen-6-ol (HC), a novel sesquiterpene derived from Lebanese wild carrot, was shown to possess a remarkable anticancer activity. The present study investigates the in vitro anticancer activity of HC and its effect ...
Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(II) polypyridyl complex

Mehanna, Stephanie; Mansour, Najwa; Audi, Hassib; Bodman-Smith, Kikki; Mroueh, Mohamad A.; Taleb, Robin I.; Daher, Costantine F.; Khnayzer, Rony S. (2019-10-01)

The use of ruthenium complexes as chemotherapeutic agents has been recently explored as one of the alternatives to conventional treatments. In the present study, two Ru(II) polypyridyl complexes were synthesized and ...
Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines

Mansour, Najwa; Mehanna, Stephanie; Mroueh, Mohamad A.; Audi, Hassib; Bodman-Smith, Kikki; Daher, Costantine F.; Taleb, Robin I.; El-Sibai, Mirvat; Khnayzer, Rony S. (2019-10-01)

The current study investigates [Ru(bipy)2(dpphen)]Cl2 [where bipy = 2,2′‐bipyridine and dpphen = 2,9‐diphenyl‐1,10‐phenanthroline] (complex 1) for photoactivatable chemotherapy (PACT) application on five cancer cell lines. ...
Spiramycin-induced liver injury

Saab, Yolande B.; Mroueh, Mohamad A. (2016-09-26)
Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer

Shebaby, Wassim N.; Mroueh, Mohamad A.; Boukamp, Petra; Bodman-Smith, Kikki; Ishac Taleb, Robin; El-Sibai, Mirvat; Daher, Costantine F. (2017-03-14)

Background Previous studies in our laboratory showed that the Lebanese Daucus carota ssp. carota (wild carrot) oil extract possesses in vitro and in vivo anticancer activities. The present study aims to examine the cytotoxic ...
β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo

Daaboul, Hamid E.; Daher, Costantine F.; Taleb, Robin I.; Boulos, Joelle; Bodman‐Smith, Kikki; Boukamp, Petra; Shebaby, Wassim N.; Dagher, Carol; El-Sibai, Mirvat; Mroueh, Mohamad A. (2017-12-15)

Background Previous studies in our laboratory showed that Daucus carota oil extract (DCOE) possesses remarkable in-vitro anticancer activity and antitumour promoting effect against DMBA/TPA skin carcinogenesis in mice. ...

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