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Browsing by Author "Merchant, Rosemina"

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1787 evaluation of transperineal prostatic administration of a PSA-activasted protoxin (PRX302) in men with luts secondary to BPH

Elhilali, Mostafa; Pommerville, Peter; Steinhoff, Gary; Egerdie, Blair; Denmeade, Samuel; Merchant, Rosemina; Buckley, Tom; Abi-Habib, Ralph J. (2018-06-13)

INTRODUCTION AND OBJECTIVES Evaluate the potential use of PSA-targeted therapy for the treatment of LUTS 2ry to BPH, through assessment of the safety and tolerability of PRX302, a proaerolysin toxin genetically modified ...
Phase 1 and 2 Studies Demonstrate the Safety and Efficacy of Intraprostatic Injection of PRX302 for the Targeted Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

Abi-Habib, Ralph; Denmeade, Samuel R.; Egerdie, Blair; Steinhoff, Gary; Merchant, Rosemina; Pommerville, Peter (2015-11-30)

Background PRX302 is a prostate specific antigen (PSA)–activated pore-forming protein toxin under development as a targeted approach for improving lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia ...
Recombinant prostate-specific antigen proaerolysin shows selective protease sensitivity and cell cytotoxicity

Abi-Habib, Ralph; Singh, Ravibhushan; Browning, Jeff L.; Wong, Kevin; Williams, Simon A.; Merchant, Rosemina; Denmeade, Samuel R.; Buckley, Thomas J.; Frankel, Arthur E. (2016-05-11)

Native proaerolysin is a channel-forming bacterial protoxin that binds to cell-surface receptors and then is activated by furin or furin-like proteases. We genetically engineered proaerolysin by replacing the furin-cleavage ...

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