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Browsing by Author "Leroy, Jerome"

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Compartmentation of Cyclic Nucleotide Signaling in the Heart

Fischmeister, Rodolphe; Castro, Liliana R.V.; Abi-Gerges, Aniella; Rochais, Francesca; Jurevicius, Jonas; Leroy, Jerome; Vandecasteele, Grégoire (2017-10-19)

A current challenge in cellular signaling is to decipher the complex intracellular spatiotemporal organization that any given cell type has developed to discriminate among different external stimuli acting via a common ...
Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice

Leroy, Jerome; Richter, Wito; Mika, Delphine; Castro, Liliana.R. V.; Abi-Gerges, Aniella; Xie, Moses; Scheitrum, Colleen; Lefebvre, Florence; Schittl, Julia; Vandecasteele, Grégoire (2017-10-19)

β-Adrenergic receptors (β-ARs) enhance cardiac contractility by increasing cAMP levels and activating PKA. PKA increases Ca2+-induced Ca2+ release via phosphorylation of L-type Ca2+ channels (LTCCs) and ryanodine receptor ...
Role of PDE3 and PDE4 for β-adrenergic control of cAMP and ICa,L in adult rat ventricular myocytes

Leroy, Jerome; Abi-Gerges, Aniella; Richter, Wito; Nikolaev, Viacheslav O.; Engelhardt, Stefan; Lohse, Martin J.; Conti, Marco; Fischmeister, Rodolphe; Vandecasteele, Gregoire (2017-10-19)

β-Adrenergic stimulation increases cAMP in cardiac cells to induce PKA-mediated phosphorylation of various proteins regulating heart function, such as the L-type Ca 2+ channels which carry I Ca,L and trigger cardiac ...
Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy

Abi-Gerges, Aniella; Castro, Liliana; Leroy, Jerome; Domergue, Valerie; Fischmeister, Rodolphe; Vandecasteele, Gregoire (2020-11-10)

Background In cardiomyocytes, phosphodiesterases (PDEs) type 3 and 4 are the predominant enzymes that degrade cAMP generated by β-adrenergic receptors (β-ARs), impacting notably the regulation of the L-type Ca2+ current ...
Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca2+ Channel Regulation in Adult Rat Ventricular Myocytes

Leroy, Jerome; Abi-Gerges, Aniella; Nikolaev, Viacheslav O.; Richter, Wito; Lecheme, Patrick; Mazet, Jean-Luc; Conti, Marco; Fischmeister, Rodolphe; Vandecasteele, Gregoire (2017-10-19)

Steady-state activation of cardiac β-adrenergic receptors leads to an intracellular compartmentation of cAMP resulting from localized cyclic nucleotide phosphodiesterase (PDE) activity. To evaluate the time course of the ...

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