Browsing by Author "Khoury, Oula"

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Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells

Khoury, Oula; Ghazale, Noura; Stone, Everett; El-Sibai, Mirvat; Frankel, Arthur; Abi-Habib, Ralph J. (2015-12-01)

In this study, we attempt to target Arginine auxotrophy in glioblastoma multiforme (GBM) cells using a pegylated recombinant human Arginase I cobalt [HuArgI (Co)-PEG5000]. We tested and characterized the activity of HuArgI ...
Targeting potential arginine auxotrophy in glioblastoma (GBM) cells using human recombinant arginase I (CO)-PEG 5000 [HuArgl (Co)-PEG5000]. (c2013)

Khoury, Oula (Lebanese American University, 2013-09-04)

Gliobastoma (Grade IV Astrocytoma) is an aggressive, malignant brain neoplasm and is the most recurrent malignant tumor in adult humans. Existing therapies for glioblastoma (GBM) include, among others, neurosurgery, ...
Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion

Al-Dimassi, Saleh; Salloum, Gilbert; Saykali, Bechara; Khoury, Oula; Liu, Shihui; Leppla, Stephen H.; Abi-Habib, Ralph; El-Sibai, Mirvat (2016-12-14)

Malignant astrocytomas are highly invasive into adjacent and distant regions of the normal brain. Understanding and targeting cancer cell invasion is an important therapeutic approach. Cell invasion is a complex process ...

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