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Browsing by Author "Khalaf, Roy A."

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Khalaf, Roy A.; Rayes, Roni; Ghasham, Mona; El Hajj, Nady; Sabbagh, Amira S.; Mahfouz, Rami A. (2018-09-13)

Aim: This study represents the first report on KIR distribution among patients with Familial Mediterranean Fever (FMF). Samples and Methods: We studied 56 unrelated Lebanese FMF patients, had their DNA typed using ...
The Candida albicans Ddr48 protein is essential for filamentation, stress response, and confers partial antifungal drug resistance

Khalaf, Roy A.; Hayek, Peter; Sadek, Helen; Beyrouthy, Berna; Dib, Leila (2016-03-21)

Background: Candida albicans is a dimorphic pathogenic fungus that causes mucosal and systemic infections. C. albicans pathogenicity is attributed to its ability to exist in different morphologic states and to respond to ...
The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence

Khalaf, Roy A.; Daher, Jalil Y.; Koussa, Joseph; Younes, Samer (2016-03-21)

The fungal pathogen Candida albicans is one of the leading causative agents of death in immunocompromised individuals. It harbors an arsenal of cell wall anchored factors that are implicated in virulence such as filamentation ...
The Candida albicans Hwp2 is necessary for proper adhesion, biofilm formation and oxidative stress tolerance

Dimassi, Hani I.; Khalaf, Roy A.; Younes, Samer; Bahnan, Wael (2015-09-30)

Candida albicans is an important fungal pathogen of humans that is responsible for the majority of mucosal and systemic candidiasis. The host–pathogen interaction in C. albicans has been the subject of intense investigation ...
The Candida albicans Hwp2p can complement the lack of filamentation of a Saccharomyces cerevisiae flo11 null strain

Khalaf, Roy A.; Younes, Samer (2016-03-18)

The opportunistic fungal pathogen Candida albicans is one of the leading agents of life-threatening infections affecting immunocompromised individuals. Many factors make C. albicans a successful pathogen. These include the ...
Characterisation of Pga1, a putative Candida albicans cell wall protein necessary for proper adhesion and biofilm formation

Malouf, Katia; Dimassi, Hani I.; Khalaf, Roy A.; Hashash, Rami; Younes, Samer; Bahnan, Wael; El-Koussa, Joseph (2015-09-30)

The fungal pathogen Candida albicans is a leading causative agent of death in immunocompromised individuals. Many factors have been implicated in virulence including filamentation-inducing transcription factors, adhesins, ...
Characterization of Hwp2, a Candida albicans putative GPI-anchored cell wall protein necessary for invasive growth

Khalaf, Roy A.; Hayek, Peter; Yazbeck, Pascale; Beyrouthy, Berna; Dib, Leila (2016-03-21)

Various factors are thought to be responsible for Candida albicans virulence, such as lipases, proteases and adhesins. Many of these factors are GPI-anchored cell surface proteins responsible for pathogenicity. Hwp2 is a ...
Characterization of the DNA binding and bending HMG domain of the yeast hypoxic repressor Rox1

Khalaf, Roy A.; Deckert, Jutta; Hwang, Soo-Myung; Zitomer, Richard S. (2016-03-18)

The yeast Rox1 hypoxic transcriptional repressor protein binds to and bends a specific DNA sequence through an HMG domain located at the N-terminus. To better understand the structure of Rox1 and how it interacts with DNA, ...
Comparative proteomic analysis of a Candida albicans DSE1 mutant under filamentous and non-filamentous conditions

Khalaf, Roy A.; Wex, Brigitte; Zohbi, Rasha (2016-03-21)

Candida albicans is a common opportunistic pathogen that causes a variety of diseases in immunocompromised hosts. In a pathogen, cell wall proteins are important virulence factors. We previously characterized Dse1 as a ...
Deletion of the Candida albicans PIR32 Results in Increased Virulence, Stress Response, and Upregulation of Cell Wall Chitin Deposition

Bahnan, Wael; Koussa, Joseph; Younes, Samer; Abi Rizk, Marybel; Khalil, Bassem; El Sitt, Sally; Hanna, Samer; El-Sibai, Mirvat; Khalaf, Roy A. (2016-03-18)

Candida albicans is a common opportunistic pathogen that causes a wide variety of diseases in a human immunocompromised host leading to death. In a pathogen, cell wall proteins are important for stability as well as for ...
Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever

Khazen, Georges; Khalaf, Roy A.; Mahfouz, Rami A.R.; Sabbagh, Amira S.; Shamseddine, Wael; Bazarbachi, Ali (2016-03-17)

Genotypic profiles of the natural killer cell immunoglobulin–like receptors (KIR) have been reported to vary among different ethnic groups and variable clinical entities. This study represents the first report on its ...
The DNA Binding Protein Rfg1 Is a Repressor of Filamentation in Candida albicans

Khalaf, Roy A.; Zitomer, Richard S. (2016-03-18)

We have identified a repressor of hyphal growth in the pathogenic yeast Candida albicans. The gene was originally cloned in an attempt to characterize the homologue of the Saccharomyces cerevisiae Rox1, a repressor of ...
Genotypic and phenotypic characterization of Candida albicans Lebanese hospital isolates resistant and sensitive to caspofungin

Toutounji, Maggie; Tokajian, Sima; Khalaf, Roy A. (2019-12-03)

The fungus Candida albicans is both a commensal and an opportunistic human pathogen, present as part of the normal human microflora causing serious mucosal, and systemic life threatening infections. The antifungal drug ...
Identification, Typing, Antifungal Resistance Profile, and Biofilm Formation of Candida albicans Isolates from Lebanese Hospital Patients

Khalaf, Roy A.; Tokajian, Sima; Bitar, Ibrahim; Harastani, Houda (2016-03-21)

As leading opportunistic fungal pathogens identification and subtyping of Candida species are crucial in recognizing outbreaks of infection, recognizing particularly virulent strains, and detecting the emergence of drug ...
Microsatellite DNA Identification and Genotyping of Candida albicans from Lebanese Clinical Isolates

Khalaf, Roy A.; Barada, Ghyda; Basma, Raida (2016-03-21)

The present study involves collecting 125 isolates labeled as C. albicans from five different Lebanese hospitals and utilizing the microsatellite genotyping test to determine the following: first, the accuracy of hospital ...
Nitrogen metabolism and virulence of Candida albicans require the GATA-type transcriptional activator encoded by GAT1

Khalaf, Roy A.; Limjindaporn, Thawornchai; Fonzi, William A. (2016-03-18)

Nitrogen acquisition and metabolism is central to microbial growth. A conserved family of zinc-finger containing transcriptional regulators known as GATA-factors ensures efficient utilization of available nitrogen sources ...
Phenotypic and cell wall proteomic characterization of a DDR48 mutant candida albicans strain

El Khoury, Pamela; Salameh, Carell; Younes, Samer; Awad, Andy; Said, Yana; Khalaf, Roy A. (2019-12-10)

Candida albicans is an opportunistic fungus possessing multiple virulence factors controlling pathogenicity. Cell wall proteins are the most important among these factors, being the first elements contacting the host. Ddr48 ...
Proteomic analysis of a candida albicans pga1 null strain

Awad, Andy; El Khoury, Pamela; Wex, Brigitte; Khalaf, Roy A. (2018-09-13)

We previously characterized Pga1, a Candida albicans (C. albicans) cell wall protein necessary for proper virulence, adhesion, and resistance to oxidative stress. By utilizing tandem mass spectrometry coupled with ...
Proteomic analysis of a Candida albicans pir32 null strain reveals proteins involved in adhesion, filamentation and virulence

El Khoury, Pamela; Awad, Andy; Wex, Brigitte; Khalaf, Roy A. (2018-09-13)

We have previously characterized Pir32, a Candia albicans cell wall protein that we found to be involved in filamentation, virulence, chitin deposition, and resistance to oxidative stress. Other than defining the cell ...
Rfg1, a protein related to the hypoxic repressor Rox1 of Saccharomyces cerevisiae, is a novel DNA binding repressor of filamentation in the pathogenic yeast, Candida albicans

Khalaf, Roy A. (State University of New York at Albany, 2018-09-13)

I have identified a repressor of hyphal growth in the pathogenic yeast Candida albicans. C. albicans is a dimorphic yeast: it can grow as single cell blastopores in rich media, but under stressful environmental conditions ...

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