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Browsing by Author "Ke, Shi"

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Browsing by Author "Ke, Shi"

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  • Comparison of visible and near-infrared wavelength-excitable fluorescent dyes for molecular imaging of cancer 
    Adams, Kristen E.; Ke, Shi; Kwon, Sunkuk; Liang, Feng; Fan, Zhen; Lu, Yang; Hirshi, Karen; Mawad, Michel E.; Barry, Micheal; Sevick-Muraca, Eva Marie (2019-07-08)
    Targeted fluorescent molecular imaging probes may provide an optimal means of detecting disease. Stable, organic fluorophores can be repeatedly excited in vivo by propagated light and consequentially can provide large ...
  • Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer 
    Sampath, Lakshmi; Kwon, Sunkuk; Ke, Shi; Wang, Wei; Schiff, Rachel; Mawad, Michel E.; Sevick-Muraca, Eva M. (2019-07-08)
    Overexpression of the human epidermal growth factor receptor (HER) family has been implicated in cancer because of its participation in signaling pathways regulating cellular proliferation, differentiation, motility, and ...
  • An imageable retinoid acid derivative to detect human cancer xenografts and study therapeutic dosing to reduce its toxicity 
    Wang, Wei; Qiu, Xiuchun; Zhang, Fujun; Sun, Jin; Cameron, Arlin G.; Wendt, Juliet A.; Mawad, Michel E.; Ke, Shi (2019-07-10)
    Developing agents with ‘seek, treat and see’ capability is critical for personalized molecular medicine. Those agents will specifically target the disease markers for diagnosis and apply the biologically effective dose for ...
  • Multi-wavelength optical imaging of human tumour xenografts 
    Wang, Wei; Cameron, Arlin G.; Wendt, Juliet A.; Mawad, Michel E.; Ke, Shi (2019-07-10)
    In vivo optical imaging methods have become a cornerstone of pre-clinical cancer research. Genetically modified cells with fluorescent or bioluminescent reporters allow researchers to non-invasively study tumour proliferation ...
  • A new optical and nuclear dual-labeled imaging agent targeting interleukin 11 receptor alpha-chain 
    Wang, Wei; Ke, Shi; Kwon, Sunkuk; Yallampalli, Sasidhar; Cameron, Arlin G.; Adams, Kristen E.; Mawad, Michel E.; Sevick-Muraca, Eva M. (2019-07-08)
    Optical imaging has great potential for studying molecular recognitions both in vivo and in vitro, yet nuclear imaging is the most effective clinical molecular imaging modality. The combination of optical and nuclear imaging ...
  • Quantitative imaging of lymph function 
    Sharma, Ruchi; Wang, Wei; Rasmussen, John C.; Joshi, Amit; Houston, Jessica P.; Adams, Kristen E.; Cameron, Arlin; Ke, Shi; Kwon, Sunkuk; Mawad, Michel E.; Sevick-Muraca, Eva M. (2019-07-08)
    Abstract Functional lymphatic imaging was demonstrated in the abdomen and anterior hindlimb of anesthetized, intact Yorkshire swine by using near-infrared (NIR) fluorescence imaging following intradermal administration ...
  • Target-specific agents imaging ectopic and orthotopic human pancreatic cancer xenografts 
    Wang, Wei; Lin, Jei; Guha, Sushovan; Tong, Zhimin; Cameron, Arlin G.; Zhang, Fujun; Qui, Xiuchun; Zou, Chaoxia; Gao, Xu; Mawad, Michel E.; Ke, Shi (2019-07-10)
    Objectives: This study aimed to develop target-specific binding agents for in vitro and in vivo imaging of human pancreatic cancer. Methods: A monoclonal neutrophil gelatinase-associated lipocalin (NGAL)-specific antibody ...