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Browsing by Author "Jurdic, Pierre"

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Browsing by Author "Jurdic, Pierre"

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  • Biphasic effects of vitamin D and FGF23 on human osteoclast biology 
    Georgess, Dan; Machuca-Gayet, Irma; Demoncheaux, Nathalie; Allard, Lise; Coury-Lucas, Fabienne; Jurdic, Pierre; Bacchetta, Justine (2019-04-04)
    Vitamin D and FGF23 play a major role in calcium/phosphate balance. Vitamin D may control bone resorption but the potential role of FGF23 has never been evaluated. The objective of this study was therefore to compare the ...
  • Comparative transcriptomics reveals RhoE as a novel regulator of actin dynamics in bone-resorbing osteoclasts 
    Georgess, Dan; Mazzorana, Marlene; Terrado, Jose; Delpart, Chrisitne; Chamot, Christophe; Guasch, Rosa M.; Perez-Roger, Ignocia; Jurdic, Pierre; Machuca-Gayet, Irma (2019-04-04)
    The function of osteoclasts (OCs), multinucleated giant cells (MGCs) of the monocytic lineage, is bone resorption. To resorb bone, OCs form podosomes. These are actin-rich adhesive structures that pattern into rings that ...
  • Podosome organization drives osteoclast-mediated bone resorption 
    Georgess, Dan; Machuca-Gayet, Irma; Blangy, Anne; Jurdic, Pierre (2019-04-04)
    Osteoclasts are the cells responsible for physiological bone resorption. A specific organization of their most prominent cytoskeletal structures, podosomes, is crucial for the degradation of mineralized bone matrix. Each ...
  • Podosome rings generate forces that drive saltatory osteoclast migration 
    Dan, Georgess; Hu, Shiqiong; Planus, Emmanuelle; Place, Christophe; Wang, Xianghui; Alibiges-Rizo, Corinne; Jurdic, Pierre; Geminard, Jean-Christophe; Mogliner, Alexander (2019-04-04)
    Podosomes are dynamic, actin-containing adhesion structures that collectively self-organize as rings. In this study, we first show by observing osteoclasts plated on bead-seeded soft substrates that podosome assemblies, ...