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Browsing by Author "Jovanovic, Dragan"

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Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-induced tumor necrosis factor-α gene expression in human macrophages and rheumatoid arthritis-affected synovial fibroblasts

Faour, Wissam; Alaaeddine, Nada; Mancini, Arturo; He, Qing Wen; Jovanovic, Dragan; Di Battista, John (2015-10-23)

Tumor necrosis factor-α (TNF-α) is a pleiotropic proinflammatory cytokine that modulates a broad range of inflammatory and immunological processes. We have investigated the potential immunomodulatory properties of prostaglandin ...
Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts ROLE IN SUPPRESSION OF c/EBP/NF-κB-MEDIATED MEKK1-INDUCED MMP-1 EXPRESSION

Faour, Wissam; He, Qing Wen; Mancini, Arturo; Jovanovic, Dragan; Antoniou, John; Di Battista, John (2016-05-09)

Cyclooxygenase-2 (COX-2) overexpression has been linked to cell survival, transformation, and hyperproliferation. We examined the regulation of the tumor suppressor gene p53 and p53 target genes by prostaglandin E2 (PGE2) ...

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