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Browsing by Author "Jaafar, Leila"

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Browsing by Author "Jaafar, Leila"

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  • Rho A and Rac1 
    Salloum, Gilbert; Jaafar, Leila; El-Sibai, Mirvat (2020-05-01)
    Cells detect external stimuli through cell-surface receptors. In cases where the stimulus is a cytokine or a growth factor, the cell responds by inducing modifications in the actin cytoskeleton. These changes are mediated ...
  • The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells 
    Al-Koussa, Houssam; El Atat, Oula; Jaafar, Leila; Tashjian, Hagop; El-Sibai, Mirvat (2020-05-01)
    Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which ...
  • The Role of Rho GTPases in VEGF Signaling in Cancer Cells 
    El Baba, Nada; Farran, Mohammad; Abi Khalil, Elie; Jaafar, Leila; Fakhoury, Isabelle; El-Sibai, Mirvat (2020-05-01)
    Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its ...
  • The Role of StarD13 in Prostate Cancer Proliferation, Motility, and Invasion 
    Jaafar, Leila (Lebanese American University, 2020-05-13)
    Prostate cancer is one of the most common tumors affecting males. Several risk factors predispose males to develop prostate cancer including age, ethnicity, and dietary habits. Even though it is easy to treat prostate ...
  • StarD13 
    Jaafar, Leila; Chamseddine, Zeinab; El-Sibai, Mirvat (2020-05-01)
    StarD13 is a tumor suppressor and a GTPase activating protein (GAP) for Rho GTPases. Thus, StarD13 regulates cell survival pathways and induces apoptosis in a p53-dependent and independent manners. In tumors, StarD13 is ...