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Browsing by Author "Jaafar, Leila"

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Browsing by Author "Jaafar, Leila"

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  • Salloum, Gilbert; Jaafar, Leila; El-Sibai, Mirvat
    Cells detect external stimuli through cell-surface receptors. In cases where the stimulus is a cytokine or a growth factor, the cell responds by inducing modifications in the actin cytoskeleton. These changes are mediated ...
  • Al-Koussa, Houssam; El Atat, Oula; Jaafar, Leila; Tashjian, Hagop; El-Sibai, Mirvat
    Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which ...
  • El Baba, Nada; Farran, Mohammad; Abi Khalil, Elie; Jaafar, Leila; Fakhoury, Isabelle; El-Sibai, Mirvat
    Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its ...
  • StarD13 
    Jaafar, Leila; Chamseddine, Zeinab; El-Sibai, Mirvat
    StarD13 is a tumor suppressor and a GTPase activating protein (GAP) for Rho GTPases. Thus, StarD13 regulates cell survival pathways and induces apoptosis in a p53-dependent and independent manners. In tumors, StarD13 is ...