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Browsing by Author "Heimberger, Amy B."

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Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas

Abou-Ghazal, Mohamed; Heimberger, Amy B.; Reina-Ortiz, Chantal; Yang, David S.; Sun, Wei; Qiao, Wei; Hiraoka, Nobuyoshi; Fuller, Gregory N. (2017-11-02)

Purpose: The incidence of regulatory T cells (Treg) in intrinsic central nervous system malignancies is unknown. Immunotherapeutic approaches that inhibit the Treg population may be limited to a subset of patients with ...
The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas

Abou-Ghazal, Mohamed; Yang, David S.; Qiao, Wei; Reina-Ortiz, Chantal; Wei, Jun; Kong, Ling-Yuan; Fuller, Gregory N.; Hiroka, Nobuyoshi; Priebe, Waldemar; Sawaya, Raymond; Heimberger, Amy B. (2017-11-02)

Purpose: The signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in most cancers, propagates tumorigenesis, and is a key regulator of immune suppression in cancer patients. We sought to ...
A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells

Abou-Ghazal, Mohamed K.; Kong, Ling-Yuan; Wei, Jun; Chakraborty, Arup; Qiao, Wei; Fuller, Gregory N.; Fokt, Izabela; Grimm, Elizabeth A.; Schimttling, Robert J.; Archer, Gary E.; Sampson, John H.; Priebe, Waldemar; Heimberger, Amy B. (2017-11-02)

urpose Activation of STAT3 has been identified as a central mediator of melanoma growth and metastasis. We hypothesized that WP1066, a novel STAT3 blockade agent, has marked antitumor activity, even against the melanoma ...
A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells

Abou-Ghazal, Mohamed K.; Kong, Ling-Yuan; Wei, Jun; Sharma, Amit K.; Barr, Jason; Fokt, Izabela; Weinberg, Jeffrey; Rao, Ganesh; Grimm, Elizabeth; Priebe, Waldemar; Heimberger, Amy B. (2017-11-02)

The activation of signal transducer and activator of transcription 3 (STAT3) has been identified as a key mediator that drives the fundamental components of melanoma malignancy, including immune suppression in melanoma ...
yuDetecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patient

Abou-Ghazal, Mohamed K.; Reina-Ortiz, Chantal; Humphries, William; Wang, Yongtao; Qiao, Wein; Crutcher, Lamonne M.; Fuller, Gregory N.; Prabhu, Sujit S.; Weinberg, Jeffrey; Heimberger, Amy B. (2017-11-02)

Background: The signal transducer and activator of transcription 3 (STAT-3) is frequently overexpressed in cancer cells, propagates tumorigenesis, and is a key regulator of immune suppression in cancer patients. The ...

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