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Browsing by Author "Hahn, Klaus M."

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Browsing by Author "Hahn, Klaus M."

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  • Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells 
    El-Sibai, Mirvat; Nalbant, Peri; Pang, Huan; Flinn, Rory J.; Sarmiento, Corina; Macaluso, Frank; Cammer, Michael; Condeelis, John S.; Hahn, Klaus M.; Backer, Jonathan M. (2015-11-09)
    Cdc42 plays a central role in regulating the actin cytoskeleton and maintaining cell polarity. Here, we show that Cdc42 is crucial for epidermal growth factor (EGF)- stimulated protrusion in MTLn3 carcinoma cells. ...
  • The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility 
    Khalil, Bassem D.; Hanna, Samer; Saykali, Bechara A.; El-Sitt, Sally; Nasrallah, Anita; Marston, Daniel; El-Sabban, Marwan; Hahn, Klaus M.; Symons, Marc; El-Sibai, Mirvat (2017-02-08)
    Malignant astrocytomas are highly invasive into adjacent and distant regions of the normal brain. Rho GTPases are small monomeric G proteins that play important roles in cytoskeleton rearrangement, cell motility, and tumor ...
  • RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells 
    El-Sibai, Mirvat; Pertz, Olivier; Pang, Huan; Yip, Shu-Chin; Lorenz, Mike; Symons, Marc; Condeelis, John S.; Hahn, Klaus M.; Backer, Jonathan M. (2015-11-04)
    Rho GTPases are versatile regulators of cell shape that act on the actin cytoskeleton. Studies using Rho GTPase mutants have shown that, in some cells, Rac1 and Cdc42 regulate the formation of lamellipodia and filopodia, ...