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Browsing by Author "Haber, Marc"

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Browsing by Author "Haber, Marc"

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  • Afghanistan's ethnic groups share a Y-chromosomal heritage structured by historical events 
    Haber, Marc; Platt, Daniel E.; Bonab, Maziar Ashrafian; Youhanna, Sonia C.; Soria-Hernanz, David F.; Martínez-Cruz, Begona; Douaihy, Bouchra; Ghassibe-Sabbagh, Michella; Rafatpanah, Hoshang; Ghanbari, Mohsen; Whale, John; Balanovsky, Oleg; Spencer Wells, R.; Comas, David; Tyler-Smith, Chris; Zalloua, Pierre A. (2019-07-25)
    Afghanistan has held a strategic position throughout history. It has been inhabited since the Paleolithic and later became a crossroad for expanding civilizations and empires. Afghanistan's location, history, and diverse ...
  • Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk 
    Milane, Aline; Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Youhanna, Sonia; Abchee, Antoine B.; Haber, Marc; Badro, Danielle A.; Salloum, Angelique K.; Douayhi, Bouchra; Nemr, Rita; Cazier, Jean-Baptiste; Zalloua, Pierre A. (2016-10-05)
    Background Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims The rationale behind this study is to explore the correlation between degree and site of coronary lesion ...
  • Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis 
    Hager, Jorg; Kamatani, Yoichiro; Cazier, Jean-Baptiste; Youhanna, Sonia; Ghassibe-Sabbagh, Michella; Platt, Daniel E.; Abchee, Antoine B.; Romanos, Jihane; Khazen, Georges; Othman, Raed; Badro, Danielle A.; Haber, Marc; Salloum, Angelique K.; Zalloua, Pierre A. (2016-03-17)
    The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide ...
  • Geographical Structure of the Y-chromosomal Genetic Landscape of the Levant 
    El-Sibai, Mirvat; Platt, Daniel E.; Haber, Marc; Xue, Yali; Youhanna, Sonia C.; Wells, R. Spencer; Izaabel, Hassan; Sanyoura, May F.; Harmanani, Haidar; Bonab, Maziar Ashrafian; Behbehani, Jaafar; Hashwa, Fuad; Tyler-Smith, Chris; Zalloua, Pierre A.; The Genographic Consortium (2015-11-04)
    We have examined the male-specific phylogeography of the Levant and its surroundings by analyzing Y-chromosomal haplogroup distributions using 5874 samples (885 new) from 23 countries. The diversity within some of these ...
  • Identifying genetic traces of historical expansions 
    Zalloua, Pierre A.; Platt, Daniel E.; El Sibai, Mirvat; Khalife, Jade; Makhoul, Nadine; Haber, Marc; Xue, Yali; Izaabel, Hassan; Bosch, Elena; Adams, Susan M.; Arroyo, Eduardo; Lopez-Parra, Ana Maria; Aler, Mercedes; Picornell, Antonia; Ramon, Misericordia; Jobling, Mark A.; Comas, David; Bertranpetit, Jaume; Tyler-Smith, Chris (2019-07-18)
    The Phoenicians were the dominant traders in the Mediterranean Sea two thousand to three thousand years ago and expanded from their homeland in the Levant to establish colonies and trading posts throughout the Mediterranean, ...
  • Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk 
    Merhi, Mahmoud; Demirdjian, Sally; Hariri, Essa; Sabbah, Nada; Youhanna, Sonia; Ghassibe-Sabbagh, Michella; Naoum, Joseph; Haber, Marc; Kanbar, Roy; Zalloua, Pierre; Khazen, Georges (2016-03-17)
    Background The role of inflammation in coronary artery disease (CAD) pathogenesis is well recognized. Moreover, smoking inhalation increases the activity of inflammatory mediators through an increase in leukotriene synthesis ...
  • Influences of history, geography, and religion on genetic structure 
    Haber, Marc; Platt, Daniel E.; Badro, Danielle A.; Xue, Yali; El-Sibai, Mirvat; Bonab, Maziar Ashrafian; Youhanna, Sonia C.; Saade, Stephanie; Soria-Hernanz, David F.; Royyuru, Ajay; Wells, R. Spencer; Tyler-Smith, Chris; Zalloua, Pierre A. (2017-08-10)
    Cultural expansions, including of religions, frequently leave genetic traces of differentiation and in-migration. These expansions may be driven by complex doctrinal differentiation, together with major population migrations ...
  • mtDNA lineages reveal coronary artery disease‐associated structures in the Lebanese population 
    Haber, Marc; Youhanna, Sonia C.; Balanovsky, Oleg; Saade, Stephanie; Martínez‐Cruz, Begona; Ghassibe-Sabbagh, Michella; Shasha, Nabil; Osman, Raed; El Bayeh, Hamid; Koshel, Sergey; Zaporozhchenko, Valery; Balanovska, Elena; Soria‐Hernanz, David F.; Platt, Daniel E. (2019-07-22)
    Population origins and ancestry have previously been found to be important determinants of coronary artery disease (CAD). This study investigates associations of Lebanese mitochondrial DNA lineages with CAD and studies ...
  • Parallel evolution of genes and languages in the Caucasus region 
    Balanovsky, Oleg; Dibirova, Khadizhat; Dybo, Anna; Mudrak, Oleg; Frolova, Svetlana; Pocheshkhova, Elvira; Haber, Marc; Platt, Daniel; Schurr, Theodore; Haak, Wolfgang; Kuznetsova, Marina; Magomed, Radzhadov; Balaganskaya, Olga; Romanov, Alexey; Renfrew, Colin; Wells, R.Spencer; Tyler-Smith, Chris; Balanovsky, Elena (2019-07-19)
    We analyzed 40 single nucleotide polymorphism and 19 short tandem repeat Y-chromosomal markers in a large sample of 1,525 indigenous individuals from 14 populations in the Caucasus and 254 additional individuals representing ...
  • Recombination gives a new insight in the effective population size and the history of the old world human populations 
    Mele, Marta; Javed, Asif; Pybus, Marc; Zalloua, Pierre; Haber, Marc; Comas, David; Netea, Mihai G.; Balamovsky, Oleg; Balanovska, Elena; Jin, Li; Yang, Yajun; Pitchappan, R.M.; Arunkumar, G.; Parida, Laxmi; Calafell, Francesc; Bertranpetit, Jaume (2019-07-22)
    The information left by recombination in our genomes can be used to make inferences on our recent evolutionary history. Specifically, the number of past recombination events in a population sample is a function of its ...
  • Recombination networks as genetic markers in a human variation study of the Old World 
    Javed, Asif; Mele, Marta; Pybus, Marc; Zalloua, Pierre; Haber, Marc; Comas, David; Netea, Mihai G.; Balanovsky, Oleg; Balanovsky, Elena; Jin, Li; Yang, Yajun; ArunKumar, GaneshPrasad; Pitchappan, Ramasamy; Bertranpetit, Jaume; Calafell, Francesc (2019-07-22)
    We have analyzed human genetic diversity in 33 Old World populations including 23 populations obtained through Genographic Project studies. A set of 1,536 SNPs in five X chromosome regions were genotyped in 1,288 individuals ...
  • T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility 
    Hirbli, Kamal; Zalloua, Pierre A.; Ghassibe-Sabbagh, Michela; Haber, Marc; Salloum, Angelique K.; Al-Sarraj, Yasser; Akle, Yasmine; Romanos, Jihane; Mouzaya, Francis; Gaugier, Dominique; Platt, Daniel E.; El Shanti, Hatem (2019-02-27)
    Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the ...
  • Y-Chromosome and mtDNA Genetics Reveal Significant Contrasts in Affinities of Modern Middle Eastern Populations with European and African Populations 
    Khazen, Georges; Zalloua, Pierre A.; Badro, Danielle A.; Douaihy, Bouchra; Haber, Marc; Youhanna, Sonia C.; Salloum, Angélique; Ghassibe-Sabbagh, Michella; Johnsrud, Brian (2016-03-17)
    The Middle East was a funnel of human expansion out of Africa, a staging area for the Neolithic Agricultural Revolution, and the home to some of the earliest world empires. Post LGM expansions into the region and subsequent ...
  • Y-chromosome R-M343 African lineages and sickle cell disease reveal structured assimilation in Lebanon 
    Haber, Marc; Platt, Daniel E.; Khoury, Simon; Badro, Danielle A.; Abboud, Miguel; Tyler-Smith, Chris; Zalloua, Pierre (2019-07-22)
    We have sought to identify signals of assimilation of African male lines in Lebanon by exploring the association of sickle cell disease (SCD) in Lebanon with Y-chromosome haplogroups that are informative of the disease ...