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Browsing by Author "Guyenet, Patrice G."

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Breathing regulation and blood gas homeostasis after near complete lesions of the retrotrapezoid nucleus in adult rats

Souza, George M.P.; Kanbar, Roy; Stornetta, Daniel S.; Abbott, Stephen B.G.; Stornetta, Ruth L.; Guyenet, Patrice G. (2019-10-17)

The retrotrapezoid nucleus (RTN) is one of several CNS nuclei that contribute, in various capacities (e.g. CO2 detection, neuronal modulation) to the central respiratory chemoreflex (CRC). Here we test how important the ...
Central CO2 chemoreception and integrated neural mechanisms of cardiovascular and respiratory control

Guyenet, Patrice G.; Stornetta, Ruth L.; Abbott, Stephen B.G.; Depuy, Seth D.; Fortuna, Michal G.; Kanbar, Roy (2016-10-10)

In this review, we examine why blood pressure (BP) and sympathetic nerve activity (SNA) increase during a rise in central nervous system (CNS) Pco2 (central chemoreceptor stimulation). CNS acidification modifies SNA by two ...
Control of breathing by raphe obscurus serotonergic neurons in mice

Depuy, Seth D.; Kanbar, Roy; Coates, Melissa B.; Stornetta, Ruth L.; Guyenet, Patrice G. (2016-10-10)

We used optogenetics to determine the global respiratory effects produced by selectively stimulating raphe obscurus (RO) serotonergic neurons in anesthetized mice and to test whether these neurons detect changes in the ...
Hypoxia silences retrotrapezoid nucleus respiratory chemoreceptors via alkalosis

Basting, Tyler M.; Burke, Peter G. R.; Kanbar, Roy; Viar, Kenneth E.; Stornetta, Daniel S.; Stornetta, Ruth L.; Guyenet, Patrice G. (2016-10-11)

In conscious mammals, hypoxia or hypercapnia stimulates breathing while theoretically exerting opposite effects on central respiratory chemoreceptors (CRCs). We tested this theory by examining how hypoxia and hypercapnia ...
Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus

Guyenet, Patrice G.; Bayliss, Douglas A.; Stornetta, Ruth L.; Kanbar, Roy; Shi, Yingtang (2017-12-15)

The retrotrapezoid nucleus, RTN, regulates breathing in a CO2 and state-dependent manner. RTN neurons are glutamatergic and innervate principally the respiratory pattern generator; they regulate multiple aspects of breathing, ...
Photostimulation of Phox2b medullary neurons activates cardiorespiratory function in conscious rats

Kanbar, Roy; Stornetta, Ruth L.; Cash, Devin R.; Lewis, Stephen J.; Guyenet, Patrice G. (2016-10-10)

Rationale: Hypoventilation is typically treated with positive pressure ventilation or, in extreme cases, by phrenic nerve stimulation. This preclinical study explores whether direct stimulation of central chemoreceptors ...
Proton detection and breathing regulation by the retrotrapezoid nucleus

Guyenet, Patrice G.; Bayliss, Douglas A.; Stornetta, Ruth L.; Ludwig, Marie-Gabrielle; Kumar, Natasha N.; Shi, Yingtang; Burke, Peter G. R.; Kanbar, Roy; Basting, Tyler M.; Holloway, Benjamin B.; Wenker, Ian C. (2016-10-11)

Abstract We discuss recent evidence which suggests that the principal central respiratory chemoreceptors are located within the retrotrapezoid nucleus (RTN) and that RTN neurons are directly sensitive to [H+]. RTN neurons ...
Regulation of visceral sympathetic tone by A5 noradrenergic neurons in rodents

Kanbar, Roy; Depuy, Seth D.; West, Gavin H.; Stornetta, Ruth L.; Guyenet, Patrice G. (2016-10-10)

The ventrolateral pons contains the A5 group of noradrenergic neurons which regulate the circulation and probably breathing. The present experiments were designed to identify these neurons definitively in vivo, to examine ...
Sciatic nerve stimulation activates the retrotrapezoid nucleus in anesthetized rats

Kanbar, Roy; Stornetta, Ruth L.; Guyenet, Patrice G. (2016-10-11)

Retrotrapezoid (RTN) neurons sustain breathing automaticity. These neurons have chemoreceptor properties but their firing is also regulated by multiple synaptic inputs of uncertain function. Here we test whether RTN, like ...
Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs

Burke, Peter G. R.; Kanbar, Roy; Viar, Kenneth E.; Stornetta, Ruth L.; Guyenet, Patrice G. (2016-10-11)

Combined optogenetic activation of the retrotrapezoid nucleus (RTN; a CO2/proton-activated brainstem nucleus) with nearby catecholaminergic neurons (C1 and A5), or selective C1 neuron stimulation, increases blood pressure ...
State‐dependent control of breathing by the retrotrapezoid nucleus

Burke, Peter G. R.; Kanbar, Roy; Basting, Tyler M.; Hodges, Walter M.; Viar, Kenneth E.; Stornetta, Ruth L.; Guyenet, Patrice G. (2016-10-11)

Breathing has different characteristics during quiet wake, non-REM or REM sleep, including variable dependence on PCO2 . We investigated whether the retrotrapezoid nucleus (RTN), a proton-sensitive structure that mediates ...

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