Background: Topotecan (TP) is an anticancer drug currently being used in the treatment of several cancer types including leukemia. However, due to its dose-limiting cytotoxicity, combination treatments have been investigated ...

Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an ...