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Browsing by Author "Fernandez, Christine"

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Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood–brain barrier in a rat brain endothelial cell model

Vautier, Sarah; Milane, Aline; Fernandez, Christine; Buyse, Marion; Chacun, Helene; Farinotti, Robert (2016-10-04)

Parkinson's disease is a neurodegenerative disorder that requires treatment by dopaminergic agonists, which may be responsible for central side effects. We hypothesized that the efflux transporter ABCB1/P-glycoprotein ...
Interactions between riluzole and ABCG2/BCRP transporter

Milane, Aline; Vautier, Sarah; Chacun, Helene; Meininger, Vincent; Bensimon, Gilbert; Farinotti, Robert; Fernandez, Christine (2016-10-04)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disease. Drugs used in this disease need to cross the blood–brain barrier (BBB). Only riluzole is approved for ALS treatment. We have investigated riluzole ...
Minocycline and riluzole brain disposition

Milane, Aline; Fernandez, Christine; Vautier, Sarah; Meininger, Vincent; Farinotti, Robert; Bensimon, Gilbert (2016-10-04)

Amyotrophic lateral sclerosis is a neurodegenerative fataldisease. The only drug recognized to increase the survivaltime is riluzole(RLZ). In animal models, minocycline (MNC)delayed the onset of the disease and increased ...
P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis

Milane, Aline; Fernandez, Christine; Dupuis, Luc; Buyse, Marion; Loeffler, Jean-Philippe; Farinotti, Robert; Meininger, Vincent; Bensimon, Gilbert (2016-10-04)

The efflux pumps located at the blood–brain barrier (BBB) prevent drugs entering the brain. As such, efflux pumps are a major obstacle to drug brain distribution. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative ...
Preclinical impact of bevacizumab on brain and tumor distribution of irinotecan and temozolomide

Milane, Aline; Goldwirt, Lauriane; Beccaria, Kevin; Carpentier, Alexandre; Idbaih, Ahmed; Schmitt, Charlotte; LEvasseur, Camille; Labussiere, Marianne; Farinotti, Robert; Fernandez, Christine (2016-10-05)

Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Prognosis of GBM patients is poor with median overall survival around 15 months. Temozolomide is the chemotherapeutic agent used in the standard ...
Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration

Milane, Aline; Vautier, Sarah; Fernandez, Christine; Chacun, Helene; Lacomble, Luccette; Farinotti, Robert (2016-10-04)

Purpose: MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson’s disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported. Methods: We have ...

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