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Browsing by Author "Ellis, Lee"

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Bevacizumab Improves Pathologic Response and Protects Against Hepatic Injury in Patients Treated With Oxaliplatin-Based Chemotherapy for Colorectal Liver Metastases

Ribero, David; Wang, Huamin; Donadon, Matteo; Zorzi, Daria; Thomas, Melanie; Eng, Cathy; Chang, David; Curley, Steven; Abdalla, Eddie; Ellis, Lee; Vauthey, Nicolas (2015-11-16)

BACKGROUND. The current study evaluated the effect of bevacizumab added to fluoropyrimidine-plus-oxaliplatin (5FU/OX) chemotherapy for colorectal liver metastases (CLM) on the pathologic response and nontumorous liver ...
The Development and Characterization of a Human Midgut Carcinoid Cell Line

Van Burenn II, George; Rashid, Asif; Yang, Anthony; Abdalla, Eddie; Gray, Micheal; Liu, Wenbiao; Somicio, Ray; Fan, Fan; Camp, Ramsay; Yao, James; Ellis, Lee (2015-11-16)

Purpose: Gastrointestinal neuroendocrine tumors (NET) are rare heterogeneous tumors that hypersecrete neuropeptides. The scarcity of good gastrointestinal NET models has limited the ability to study potential therapeutic ...
Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women

Hassan, Manal; Spitz, Margaret; Thomas, Melanie; El-Deeb, Adel; Glover, Katrina; Nguyem, Nga; Chan, Wenyaw; Kaseb, Ahmed; Curley, Steven; Vauthey, Nicolas; Ellis, Lee; Abdalla, Eddie; Lozano, Richard; Patt, Yehuda; Brown, Thomas; Abbruzzese, James; Li, Donghui (2015-11-17)

The International Agency for Research on Cancer has declared smoking to be a risk factor for hepatocellular carcinoma (HCC). However, passive exposure to cigarette smoke and use of noncigarette tobacco products on the risk ...
Identification of Cancer Stem Cells in Human Gastrointestinal Carcinoid and Neuroendocrine Tumors

Gaur, Puja; Sceusi, Eric; Samuel, Shaija; Xia, Ling; Zhou, Yunfei; Lu, Jia; Tozzi, Federico; Lopez-Berestein, Gabriel; Vivas-Mejia, Pablo; Fleming, Jason; Abdalla, Eddie; Curley, Steven; Vauthey, Jean-Nicolas; Sood, Anil; Yao, James; Ellis, Lee (2015-11-19)

Background & Aims Metastatic gastrointestinal neuroendocrine tumors (NETs) frequently are refractory to chemotherapy. Chemoresistance in various malignancies has been attributed to cancer stem cells (CSCs). We sought ...
Is extended hepatectomy for hepatobiliary malignancy justified?

Abdalla, Eddie; Vauthey, Nicolas; Pawlik, Timothy; Arens, James; Nemr, Rabih; Wei, Steven; Kennamer, Debra; Ellis, Lee; Curley, Steven (2015-11-11)

Background: Extended hepatectomy may be required to provide the best chance for cure of hepatobiliary malignancies. However, the procedure may be associated with significant morbidity and mortality. Methods: We ...
Morbidity of Staged Proctectomy After Hepatectomy for Colorectal Cancer

Tzeng, Ching-Wei; Aloia, Thomas; Vauthey, Jean-Nicolas; Chang, George; Ellis, Lee; Feig, Barry; Curley, Steven; Skibber, John; Abdalla, Eddie; You, Nancy; Rodriguez-Bigas, Miguel (2015-11-20)

Background Proctectomy after hepatectomy, or the reverse approach, is an alternative to traditional sequencing for advanced liver metastases with asymptomatic colorectal primary tumors. We sought to evaluate the surgical ...
Pathologic Response to Preoperative Chemotherapy

Blazer III, Dan; Kishi, Yoji; Maru, Dipen; Shin Chun, Yun; Overman, Micheal; Fogelman, David; Eng, Cathy; Chang, David; Wang, Huamin; Zorzi, Daria; Ribero, Dario; Ellis, Lee; Glover, Katrina; Wolff, Robert; Curley, Steven; Abdalla, Eddie; Vauthey, Nicolas (2015-11-16)

Purpose The primary goal of this study was to evaluate whether pathologic response to chemotherapy predicts patient survival after preoperative chemotherapy and resection of colorectal liver metastases (CLM). The secondary ...
Preoperative Bevacizumab Does Not Significantly Increase Postoperative Complication Rates in Patients Undergoing Hepatic Surgery for Colorectal Cancer Liver Metastases

Kesmodel, Susan; Ellis, Lee; Lin, E.; Chang, George; Abdalla, Eddie; Kopetz, Scott; Vauthey, Jean-Nicolas; Rodriguez-Bigas, Miguel; Curley, Steven; Feig, Barry (2015-11-17)

Purpose Although bevacizumab (BV) increases survival rates when used with chemotherapy (CTX) in patients who have metastatic colorectal cancer (CRC), an increase in wound complications has been observed in patients who ...
Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases

Abdalla, Eddie; Vauthey, Nicolas; Ellis, Lee; Ellis, Vicky; Pollock, Raphael; Hess, Kenneth; Curley, Steven; Broglio, Kristine (2015-11-10)

Objective: To examine recurrence and survival rates for patients treated with hepatic resection only, radiofrequency ablation (RFA) plus resection or RFA only for colorectal liver metastases. Summary Background ...
Results of a Single-Center Experience With Resection and Ablation for Sarcoma Metastatic to the Liver

Abdalla, Eddie; Pawlik, Timothy; Vauthey, Nicolas; Pollock, Raphael; Ellis, Lee; Curley, Steven (2015-11-12)

Hypothesis A subset of patients with sarcoma liver metastasis may benefit from hepatic resection and/or ablation. Design Retrospective review of prospectively collected cancer center database records. Patients and ...

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