Browsing by Author "Duesbery, Nicholas S."

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BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin

Abi-Habib, Ralph J.; Urieto, Jeffrey O.; Leppla, Stephen H.; Duesbery, Nicholas S.; Frankel, Arthur E. (2015-11-30)

Anthrax lethal toxin, composed of protective antigen and lethal factor, was tested for cytotoxicity to human melanoma cell lines and normal human cells. Eleven of 18 melanoma cell lines were sensitive to anthrax lethal ...
Characterization of urokinase plasminogen activator-activated recombinant anthrax toxin for targeted cancer therapy

Abi-Habib, Ralph J.; Singh, Ravibhushan; Duesbery, Nicholas S.; Liu, Shihui; Bugge, Thomas H.; Leppla, Stephen H. (2018-06-18)

Anthrax lethal toxin (LeTx), secreted by Bacillus anthracis, consists of protective antigen (PrAg) and lethal factor (LF). Following binding to its ubiquitously expressed cell surface receptors tumor endothelium marker 8 ...
Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice

Abi-Habib, Ralph J.; Singh, Ravibhushan; Leppla, Stephen H.; Greene, John J.; Ding, Yan; Berghuis, Bree; Duesbery, Nicholas S.; Frankel, Arthur E. (2015-11-30)

Purpose: Anthrax Lethal Toxin (LeTx), composed of protective antigen and lethal factor, catalytically cleaves mitogen-activated protein kinase (MAPK) kinases and inhibits the MAPK signaling pathways. The majority of ...

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