Browsing by Author "Bugge, Thomas"

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Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor–induced hepatotoxicity is mediated by Kupffer cells

Abi-Habib, Ralph J.; Westcott, Marlena; Cohen, Kimberley; Willingham, Mark; Lui, Shihui; Bugge, Thomas; Leppla, Stephen H.; Frankel, Arthur (2016-05-10)

DT388GMCSF, a fusion toxin composed of the NH2-terminal region of diphtheria toxin (DT) fused to human granulocyte-macrophage colony-stimulating factor (GMCSF) has shown efficacy in the treatment of acute myeloid leukemia. ...
A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

Abi-Habib, Ralph J.; Singh, Ravibhushan; Liu, Shihui; Bugge, Thomas; Leppla, Stephen H.; Frankel, Arthur (2015-12-01)

Urokinase plasminogen activator (uPA) is a tumor-specific protease highly expressed in several types of solid tumors and rarely present on normal cells under physiologic conditions. Due to its high expression on metastatic ...
A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

Abi-Habib, Ralph J.; Lui, Shihui; Bugge, Thomas; Leppla, Stephen H.; Frankel, Arthur (2015-11-30)

Novel agents to treat acute myeloid leukemia (AML) are needed with increased efficacy and specificity. We have synthesized a dual-specificity fusion toxin DTU2GMCSF composed of the catalytic and translocation domains of ...

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