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Browsing by Author "Browning, Jeff L."

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Browsing by Author "Browning, Jeff L."

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  • PSA-activated proaerolysin as a prostate specific cancer therapy 
    Abi-Habib, Ralph; Browning, Jeff L.; Singh, Ravibhushan; Carter, Carol; Ortiz, Janelle (2018-06-18)
    Native proaerolysin is a channel-forming bacterial protoxin that is activated upon cleavage by host proteases such as furin. PRX302 is an engineered form of proaerolysin in which the furin cleavage site has been replaced ...
  • Recombinant prostate-specific antigen proaerolysin shows selective protease sensitivity and cell cytotoxicity 
    Abi-Habib, Ralph; Singh, Ravibhushan; Browning, Jeff L.; Wong, Kevin; Williams, Simon A.; Merchant, Rosemina; Denmeade, Samuel R.; Buckley, Thomas J.; Frankel, Arthur E. (2016-05-11)
    Native proaerolysin is a channel-forming bacterial protoxin that binds to cell-surface receptors and then is activated by furin or furin-like proteases. We genetically engineered proaerolysin by replacing the furin-cleavage ...