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Browsing by Author "Abouantoun, Thamara J."

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Imatinib blocks migration and invasion of medulloblastoma cells by concurrently inhibiting activation of platelet-derived growth factor receptor and transactivation of epidermal growth factor receptor

Abouantoun, Thamara J.; MacDonald, Tobey J. (2016-09-27)

Platelet-derived growth factor (PDGF) receptor (PDGFR) expression correlates with metastatic medulloblastoma. PDGF stimulation of medulloblastoma cells phosphorylates extracellular signal-regulated kinase (ERK) and promotes ...
Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells

Castellino, R.C.; MacDonald, T.J.; Abouantoun, Thamara J. (2016-09-27)

We previously showed that inhibition of the platelet-derived growth factor receptor (PDGFR) blocks the survival and migration of medulloblastoma cells. Identification of in vitro PDGFR-targeting pharmacologic agents that ...

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