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Browsing by Author "Abdalla, Eddie"

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Activation of Src Kinase in Primary Colorectal Carcinoma

Abdalla, Eddie; Allgayer, Heike; Boyd, Douglas; Heiss, Markus; Curley, Steven; Gallick, Gary (2015-11-10)

BACKGROUND. The specific activity of the non-receptor protein tyrosine kinase, Src, is increased in the majority of colon and rectal adenocarcinomas compared to normal mucosa. However, the prognostic significance of this ...
Advances in hepato–pancreato biliary surgery

Abdalla, Eddie (2015-11-20)

The Americas Hepato–Pancreato Biliary Association (AHPBA) Annual 2011 Meeting provided a forum for discussion of multidisciplinary advances surrounding six tracks including the liver, biliary system, liver transplantation, ...
Aggressive Combined Modality Therapy for Recurrent Colorectal Cancer Involving the Duodenum and Pancreas

Overman, Micheal; Fogelman, David; Al-Kali, Aref; Crane, Christopher; Evans, Douglas; Abdalla, Eddie; Pisters, Peter; Kopetz, Scott; Eng, Cathy; Wolff, Robert (2015-11-17)

We report 5 cases in which the recurrence of colorectal cancer (CRC) presented as a mass involving the duodenum and pancreas. The treatment approach for such recurrences is not standardized, and in particular, the benefits ...
AHPBA/SSO/SSAT Sponsored Consensus Conference on Multidisciplinary Treatment of Hepatocellular Carcinoma

Dixon, Elijah; Abdalla, Eddie; Schwarz, Roderich; Vauthey, Jean-Nicolas (2015-11-19)
AHPBA/SSO/SSAT sponsored consensus conference on the multidisciplinary treatment of colorectal cancer metastases

Schwarz, Roderich; Abdalla, Eddie; Aloia, Thomas; Vauthey, Jean-Nicolas (2015-11-20)
Arterial levels of oxidized glutathione (GSSG) reflect oxidant stress in vivo

Abdalla, Eddie; Mickeal, Caty; Guice, Karen; Hinshaw, Daniel; Oldham, Keith (2015-11-09)

Neutrophil-related, oxidant-mediated injury to the pulmonary microvasculature appears to follow endotoxemia, cutaneous thermal injury, and ischemia—reperfusion injury to the liver or intestine. Glutathione is an important ...
Association between hypothyroidism and hepatocellular carcinoma

Hassan, Manal; Kaseb, Ahmed; Li, Donghui; Vauthey, Jean-Nicolas; Thomas, Melanie; Curley, Steven; Spitz, Margaret; Sherman, Steven; Abdalla, Eddie; Davila, Marta; Lozano, Richard; Hassan, Deena; Wenyaw, Chan; Brown, Thomas; Abbruzzese, James; Patt, Yehuda (2015-11-17)

Thyroid hormones play an essential role in lipid mobilization, lipid degradation, and fatty acid oxidation. Hypothyroidism has been associated with nonalcoholic steatohepatitis; however, the association between thyroid ...
Association of Computed Tomography Morphologic Criteria With Pathologic Response and Survival in Patients Treated With Bevacizumab for Colorectal Liver Metastases

Shin Chun, Yun; Vauthey, Jean-Nicolas; Boonsirikamcha, Piyaporn; Maru, Dipen; Kopetz, Scott; Palavecino, Martin; Curley, Steven; Abdalla, Eddie; Kaur, Harmeet; Charnsangavej, Chusilp; Loyer, Evelyne (2015-11-17)

Context The standard criteria used to evaluate tumor response, the Response Evaluation Criteria in Solid Tumors (RECIST), were developed to assess tumor shrinkage after cytotoxic chemotherapy and may be limited in assessing ...
Bevacizumab Improves Pathologic Response and Protects Against Hepatic Injury in Patients Treated With Oxaliplatin-Based Chemotherapy for Colorectal Liver Metastases

Ribero, David; Wang, Huamin; Donadon, Matteo; Zorzi, Daria; Thomas, Melanie; Eng, Cathy; Chang, David; Curley, Steven; Abdalla, Eddie; Ellis, Lee; Vauthey, Nicolas (2015-11-16)

BACKGROUND. The current study evaluated the effect of bevacizumab added to fluoropyrimidine-plus-oxaliplatin (5FU/OX) chemotherapy for colorectal liver metastases (CLM) on the pathologic response and nontumorous liver ...
Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli

Abdalla, Eddie; Su, Li-Kuo; Law, Calvin; Kohlmann, Wendy; Rashid, Asif; Vauthey, Nicolas (2015-11-10)

BACKGROUND Certain primary hepatic tumors have been associated with familial adenomatous polyposis (FAP), a condition caused by germline mutations of the adenomatous polyposis coli (APC) gene. However, a genetic association ...
Blood Neutrophil-to-Lymphocyte Ratio Predicts Survival in Patients with Colorectal Liver Metastases Treated with Systemic Chemotherapy

Abdalla, Eddie; Kishi, Yoji; Kopetz, Scott; Chun, Yun Shin; Palavecino, Martin; Vauthey, Jean-Nicolas (2015-11-17)

Background Whether neutrophil-to-lymphocyte ratio (NLR) predicts survival of patients with colorectal liver metastases (CLM) treated with systemic chemotherapy remains unclear. Methods Clinicopathologic data were reviewed ...
Body surface area and body weight predict total liver volume in Western adults

Abdalla, Eddie; Vauthey, Nicolas; Doherty, Dorota; Gertsch, Philippe; Fenstermacher, Marc; Loyer, Evelyne; Leurt, Jan; Materne, Roland; Wang, Xuemei; Encarnacion, Arthur; Herron, Delise; Mathey, Christian; Ferrari, Giovanni; Charnsangavej, Chusilp; Do, Kim-Anh; Denys, Alban (2015-11-10)

Computed tomography (CT) is used increasingly to measure liver volume in patients undergoing evaluation for transplantation or resection. This study is designed to determine a formula predicting total liver volume (TLV) ...
Borderline Resectable Pancreatic Cancer

Katz, Matthew; Pisters, Peter; Evans, Douglas; Sun, Charlotte; Lee, Jeffrey; Fleming, Jason; Vauthey, Jean-Nicolas; Abdalla, Eddie; Crane, Christopher (2015-11-17)

Background Patients with borderline resectable pancreatic adenocarcinoma (PA) include those with localized disease who have tumor or patient characteristics that preclude immediate surgery. There is no optimal treatment ...
Breast Disease-Related Educational Outcomes at the University of Florida

Abdalla, Eddie; Lind, Scott; Flynn, Timothy; Tepas, Joseph; Copeland III, Edward (2015-11-10)

The purpose of this study was to assess resident knowledge related to breast disease at the University of Florida. In addition, we surveyed graduates of our surgery program regarding the importance of breast disease in ...
Carotid artery revascularization through a radiated field

Abdalla, Eddie; Lesèche, Guy; Castier, Yves; Chataigner, Olivier; Francis, Fady; Besnard, Mathieu; Thabut, Gabriel; Cerceau, Olivier (2015-11-10)

Objective Extracranial carotid stenosis is a complication of external head and neck irradiation. The safety and durability of carotid artery revascularization through a radiated field has been debated. We describe the ...
Chemotherapy prior to Hepatic Resection for Colorectal Liver Metastases

Vauthey, Nicolas; Abdalla, Eddie (2015-11-16)

Background: Improved efficacy of chemotherapy for treatment of colorectal liver metastases (CLM) has renewed interest in the use of systemic treatment as part of a ‘potentially curative’ treatment plan for patients with ...
Chemotherapy Regimen Predicts Steatohepatitis and an Increase in 90-Day Mortality After Surgery for Hepatic Colorectal Metastases

Vauthey, Nicolas; Pawlik, Timothy; Ribero, Dario; Wu, Tsung-Teh; Zorzi, Daria; Hoff, Paulo; Xiong, Henry; Eng, Cathy; Lauwers, Gregory; Mino-Kenudson, Mari; Risio, Mauro; Muratore, Andrea; Capussotti, Lorenzo; Curley, Steven; Abdalla, Eddie (2015-11-12)

Purpose Chemotherapy before resection of hepatic colorectal metastases (CRM) may cause hepatic injury and affect postoperative outcome. Patients and Methods Four hundred six patients underwent hepatic resection of CRM ...
Chemotherapy With Bevacizumab Does Not Affect Liver Regeneration After Portal Vein Embolization in the Treatment of Colorectal Liver Metastases

Zorzi, Daria; Shin Chun, Yun; Madoff, David; Abdalla, Eddie; Vauthey, Jean-Nicolas (2015-11-17)

Background Blockage of vascular endothelial growth factor (VEGF) in murine models has been shown to impair liver regeneration after partial hepatectomy. The aim of this study was to evaluate the effects of chemotherapy ...
Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases

Zorzi, D.; Laurent, A.; Pawlik, T.M.; Lauwers, G.Y.; Vauthey, J.-N.; Abdalla, Eddie (2015-11-16)

Background: Preoperative systemic chemotherapy is increasingly used in patients who undergo hepatic resection for colorectal liver metastases (CLM). Although chemotherapy-related hepatic injury has been reported, the ...
Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma

Kaseb, Ahmed; Morris, Jeffrey; Hassan, Manal; Siddiqui, Adnan; Lin, E.; Xia, Lianchun; Abdalla, Eddie; Vauthey, Jean-Nicolas; Aloia, Thomas; Krishnan, Sunil; Abbruzzese, James (2017-04-11)

Purpose Cirrhosis and hepatocellular carcinoma (HCC) together form a two-disease state that affects survival of patients with HCC and dictates treatment decisions and prognostic stratification of patients in clinical trials. ...

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