2024-03-29T12:44:51Zhttps://laur.lau.edu.lb:8443/oai/requestoai:laur.lau.edu.lb:10725/4312023-05-10T09:56:17Zcom_10725_2058col_10725_2074
Barada, Sana Ali
Itani, Siham Moh'd Kheir
2011-05-05T09:00:15Z
2011-05-05T09:00:15Z
2011-05-05
1999-07-01
http://hdl.handle.net/10725/431
https://doi.org/10.26756/th.2023.574
Includes bibliographical references (leaves 34-39).
Osteoporosis is one of the commonest public health problems of modern medicine. It is the major underlying cause of bone fractures in postmenopausal women and elderly. Factors that influence the occurrence of osteoporosis include:
a-Optimal peak bone mass attained in the first 2 to 3 decades of life.
b-And the rate at which bone is lost in later years.
Calcium intake is one of a number of factors that affect peak bone mass. Adequate calcium intake is critical to achieving optimal peak bone mass and modifies the rate of bone loss associated with aging. The critical importance of calcium on skeletal health is illustrated in the National Institute of Health Consensus Panel recommendations that are age and gender specific. Calcium, which is a major component of mineralized tissues and is required for normal growth and development of the skeleton and teeth, can be provided through dairy products or calcium supplements. However, accuracy of calcium or calcium/vitamin D products is undetermined. Furthermore, certain reports from the US raise concern regarding the contamination of certain calcium supplements with heavy metals. The purpose of this investigation is to evaluate the purity and accuracy of commonly used calcium and calcium/vitamin D supplements in Lebanon. This investigation was a collaborative project between LAU and AUB-MC. The extraction and analytical studies were performed at the core research facility of faculty of medicine at AUB and the university Core Environment Laboratory.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-05-05T09:00:15Z
No. of bitstreams: 1
Sana_Ali_Barada_Thesis.pdf: 21485001 bytes, checksum: 9ee2df4d11d616643053b9a3316c285b (MD5)
Made available in DSpace on 2011-05-05T09:00:15Z (GMT). No. of bitstreams: 1
Sana_Ali_Barada_Thesis.pdf: 21485001 bytes, checksum: 9ee2df4d11d616643053b9a3316c285b (MD5)
1 bound copy: xv, 39 leaves; ill. (some col.); 30 cm. available at RNL.
en
Calcium -- Analysis
Vitamin D -- Analysis
Calcium -- Analysis -- Laboratory manuals
Calcium -- Therapeutic use -- Testing
Osteoporosis -- Prevention
Clinical analysis of commonly used calcium, calcium/vitamin D tablets in Lebanon. (c1999)
Other
Summer I
Pharmacy
Dr. Mohammad Mroueh
Dr. Gabriel Maliha
RA
Doctor of Pharmacy
Pharmacy
Dr. Ghada EI-Hall Fuleihan
ORIGINAL
Sana_Ali_Barada_Thesis.pdf
Sana_Ali_Barada_Thesis.pdf
pdf format
application/pdf
5045781
https://laur.lau.edu.lb:8443/bitstream/10725/431/3/Sana_Ali_Barada_Thesis.pdf
fa32ae1eab5d51159bb74506ba9da094
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/431/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/431
oai:laur.lau.edu.lb:10725/431
2023-05-10 12:56:17.391
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/4372017-09-25T07:06:54Zcom_10725_2058col_10725_2074
Zarikian, Karen Awadis
2011-05-10T05:42:58Z
2011-05-10T05:42:58Z
2002
2011-05-10
2002-07-01
http://hdl.handle.net/10725/437
https://doi.org/10.26756/th.2002.8
In the second half of this century, emphasis on diet related diseases increased as the major cause of mortality shifted from infections to chronic diseases. Cardiovascular disease (CYD) has been the number one killer in the United States since 1900. According to the American Heart Association 2002 Heart Statistical Update, one death is reported from CYD every 33 seconds. Atherosclerosis is the major underlying cause of coronary heart disease. Diet rich with cholesterol and saturated fat is believed to increase plasma levels of total and low density lipoprotein cholesterol, the primary lipoprotein mediating atherosclerosis. According to the 200 I guidelines of the National Cholesterol
Education Program Panel III, dietary treatment must proceed pharmacological therapy in hyperlipidemic patients for a three month period. It has been hypothesized that vegetable oils such as olive oil, canola oil, soybean oil, are major sources of monounsaturated and polyunsaturated fatty acids and that they have more favorable effects on the distribution of cholesterol. Olive Oil is the major fat used in the Mediterranean diet. Different environmental factors and harvesting techniques influence the chemical composition of olive oil. The primary objective of this study was to identify the fatty acid, sterol and squalene concentrations and acidity in the Lebanese olive oil prepared by the cold press and automated methods. Another objective was to observe the influence of a ten week olive oil enriched diet on the plasma lipid profile, insulin levels, coagulation time and Apolipoprotein B 100 and B 48 levels in rats. Olive oil samples were obtained from 11 different Lebanese areas. The identification of the fatty acids, sterols and squalene was performed on gas chromatography mass spectrometry (GeMS) and the acidity was identified by titration. In the second phase of the study, 42 rats were divided into three groups and fed for J 0 weeks the following diets: a) normal rat diet, b ) diet enriched with olive oil prepared by the automated method and c ) diet enriched with oil prepared by the cold press method. The oil of black olives prepared by the automated method from Beshaale (Northern Lebanon) contained the highest percentage of oleic acid and sterol concentration whereas the oil from Zrarieh (southern Lebanon) contained the least. On the other hand, the highest squalene concentration was found oil obtained from green olives brought from Beshaale. The most acidic oil was the one obtained from Koura, Kfar Akka (northern Lebanon), prepared by the automated method. Following ten week low fat verses high fat diet, no significant difference was observed among the various groups in lipid profile, insulin and Apo B 100 & 48 levels. There was a decrease in clotting time in the group fed the automated olive oil compared to the control and an increase in the clotting time in the group fed cold press olive oil compared to the automated. These findings suggest possible altered fat metabolism in rats. Further studies in humans might yield better conclusive results. In conclusion, the present study was able to identify the chemical composition of Lebanese olive oil in terms of fatty acids, sterols and squalene content. In addition, the increased acidity in some of the consumed olive oils is of great concern. In order to observe difference in lipid profile, well designed dietary experiments in humans is needed, because the squalene metabolism in rats is different than in humans.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-05-10T05:42:58Z
No. of bitstreams: 1
Karen_Awadis_Zarikian_Thesis.pdf: 26128623 bytes, checksum: f6e6b7626f888d481ad3b511cddb5ea7 (MD5)
Made available in DSpace on 2011-05-10T05:42:58Z (GMT). No. of bitstreams: 1
Karen_Awadis_Zarikian_Thesis.pdf: 26128623 bytes, checksum: f6e6b7626f888d481ad3b511cddb5ea7 (MD5)
1 bound copy: 76 p.; ill. available at RNL.
en
Oils and fats -- Analysis
Lipoproteins
Lipids in human nutrition
The chemical analysis of Lebanese olive oil and the influence of oil enriched diet on Plasma Lipid profile in rats. (c2002)
Thesis
Summer I
Pharmacy
1977-06-26
199730030
Dr. Gabriel Maliha
Dr.Yoland Saab
RA
Doctor of Pharmacy
Pharmacy
Dr. Mohamad Mroueh
ORIGINAL
Karen_Awadis_Zarikian_Thesis_Redacted.pdf
Karen_Awadis_Zarikian_Thesis_Redacted.pdf
application/pdf
6051091
https://laur.lau.edu.lb:8443/bitstream/10725/437/3/Karen_Awadis_Zarikian_Thesis_Redacted.pdf
4bec31e79858c9d9d7f27d061dd8bbfc
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/437/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/437
oai:laur.lau.edu.lb:10725/437
2017-09-25 10:06:54.908
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/4602017-09-25T07:06:55Zcom_10725_2058col_10725_2074
Chahine, Corinne
2011-05-13T08:26:54Z
2011-05-13T08:26:54Z
2001
2011-05-13
2001-06-08
http://hdl.handle.net/10725/460
https://doi.org/10.26756/th.2001.2
Background: Treatment regimens for Helicobacter pylori (H. pylori) usually combine an acid reducing agent (proton-pump inhibitor, H2-antagonist) with two or three antibiotics (macrolide, metronidazole, tetracycline, amoxicillin), with a duration varying from seven to fourteen days. Recently, studies have shown acceptable eradication rates using short-term triple-therapy regimens. Azithromycin, a new generation macrolide with improved pharmacokinetic properties (long t1/2 life and large volume of distribution), has been proposed for H. pylori treatment with variable radication rates of 57% to 93%. Objectives: The purpose of this study is to establish the safety and efficacy of two short-term triple-therapy regimens (lansoprazole, azithromycin and amoxicillin) for H. pylori eradication. Methods: From April 2000 to September 2000 thirty symptomatic patients with a positive rapid urease assay for H. pylori were assigned to receive either a 3-day therapy (Group A) or a 5-day therapy (Group B). In both groups, patients received lansoprazole 30mg bid on day 1; lansoprazole 30mg bid, amoxicillin 19 bid and azithromycin on days 2 and 3. Patients in group B received lansoprazole 30mg bid and amoxicillin 19 bid for two additional days (4 and 5). In-vitro antimicrobial susceptibility of H. pylori recovered from gastric biopsies was tested using the epsilometer test (E-test). Compliance and side effects were monitored. Evaluation of H. pylori eradication was done a minimum of four weeks after end of therapy using the 14C-urea breath test.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-05-13T08:26:54Z
No. of bitstreams: 1
Corinne_Chahine_Thesis.pdf: 32025628 bytes, checksum: a38220e0181b4d3cb1434aed32b461a8 (MD5)
Made available in DSpace on 2011-05-13T08:26:54Z (GMT). No. of bitstreams: 1
Corinne_Chahine_Thesis.pdf: 32025628 bytes, checksum: a38220e0181b4d3cb1434aed32b461a8 (MD5)
1 bound copy: xii, 83 l. available at RNL.
en
Helicobacter pylori
Helicobacter pylori infections
Ultra-short therapy for the treatment of Helicobacter pylori. (c2001)
Thesis
Spring
Pharmacy
199332990
Dr. Shihadeh N. Nayfeh
Dr. Ala' Sharara
Dr. Gabriel Maliha
RA
Doctor of Pharmacy
Pharmacy
Dr. Oussayma Moukhachen
ORIGINAL
Corinne_Chahine_Thesis_Redacted.pdf
Corinne_Chahine_Thesis_Redacted.pdf
application/pdf
7838723
https://laur.lau.edu.lb:8443/bitstream/10725/460/3/Corinne_Chahine_Thesis_Redacted.pdf
98770f960ffa82245300a815a23a3b9a
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/460/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/460
oai:laur.lau.edu.lb:10725/460
2017-09-25 10:06:55.596
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/4612017-09-25T07:06:55Zcom_10725_2058col_10725_2074
Zeitoun, Abeer Abbas
2011-05-13T09:15:12Z
2011-05-13T09:15:12Z
2001
2011-05-13
2001-06-17
http://hdl.handle.net/10725/461
https://doi.org/10.26756/th.2001.3
(Aspicot®) is an enteric coated aspirin that is being extensively used among patients in the Middle East, including Lebanon where this drug is manufactured, without any clinical in-vivo implication showing or confirming its bioequivalence. Therefore, this investigation was carried out LO evaluate the in-vitro dissolution as well as the bioavailability and pharmacokinetic properties of two tablet oral dosage forms of enteric coated aspirin, Aspirin Protect® (Bayer©, Germany) and Aspicot® (Pharmaline©, Lebanon) in a single dose of 200 mg among healthy volunteers.
Method: Twelve healthy volunteers (seven males, five females), were enrolled in the study. Each volunteer received a single dose of each drug in an open randomized two-way crossover study, with a washout period of seven days. Blood samples were obtained at different time intervals over a period of 12 hours. These samples were then analyzed for serum acetylsalicylic acid and salicylic acid levels, using a sensitive HPLC assay.
Results: The two products were found to comply with the compendial requirements for both disintegration and content uniformity; and their in -vitro dissolution characteristics were similar. Moreover, there was no statistically significant difference with respect to peak serum concentration (The Cmax values for Aspicot® (23,66 ± 16,26 ~g / mL) and Aspirin Protect® (21.73 ± 11.33 ug / mL) or to corresponding peaks time (the Tmax values ( 4,92 ± 2.35 hours and 4,58 ± 1,5 1 hours for Aspicot® and Aspirin Protect® respectively), Furthermore, the difference between area under the serum concentration time curve for the two products (the AUC for Aspicot® (66,20 ± 42,90 ug / mL) and Aspirin Protect® (64,79 ± 38,02 ug / mL) was not statistically significant, with P > 0,05.
Conclusion: The findings in this study indicate that the two products are bioequivalent in terms of bioavailability and pharmacokinetic properties on healthy volunteers.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-05-13T09:15:12Z
No. of bitstreams: 1
Abeer_Abbas_Zeitoun_Thesis.pdf: 27524325 bytes, checksum: 62fb17c6f62eac5fd996cf6b0ff377bf (MD5)
Made available in DSpace on 2011-05-13T09:15:12Z (GMT). No. of bitstreams: 1
Abeer_Abbas_Zeitoun_Thesis.pdf: 27524325 bytes, checksum: 62fb17c6f62eac5fd996cf6b0ff377bf (MD5)
1 bound copy: 70 leaves available at RNL.
en
Aspirin
Aspirin -- Drug effects
A comparative single-dose bioequivalence study of two enteric coated Aspirin brands among healthy volunteers. (c2001)
Thesis
Spring
Pharmacy
1976-06-01
199404580
Dr. Mroueh
RA
Doctor of Pharmacy
Pharmacy
Dr. Jean Dib
ORIGINAL
Abeer_Abbas_Zeitoun_Thesis_Redacted.pdf
Abeer_Abbas_Zeitoun_Thesis_Redacted.pdf
application/pdf
6532808
https://laur.lau.edu.lb:8443/bitstream/10725/461/3/Abeer_Abbas_Zeitoun_Thesis_Redacted.pdf
79bdca423fcab053b04d93ce08c765fa
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/461/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/461
oai:laur.lau.edu.lb:10725/461
2017-09-25 10:06:55.624
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/5602017-09-25T07:06:57Zcom_10725_2058col_10725_2074
Homsi, Maria
2011-09-14T11:13:31Z
2011-09-14T11:13:31Z
2001
2011-09-14
2001-10-11
http://hdl.handle.net/10725/560
https://doi.org/10.26756/th.2001.6
Availability of oral antibiotics with superior pharmacokinetic profiles and safety has enabled early conversion from parenteral to oral antibiotic therapy in attempt to reduce overall cost. In Lebanon, no hospital has set guidelines regarding switching from intravenous (IV) to oral (PO) antibiotics. The objective of this study was to evaluate such practice at a tertiary care medical center. Patients admitted to AUBMC, receiving intravenous ciprofloxacin, levofloxacin, or ofloxacin were enrolled prospectively. Variables were collected daily from admission until discharge, including antibiotics prescribed, vital signs, CBC, and cultures. Date of switch (if applicable), oral antibiotic chosen, mean time to switch, mean hospital duration, and mean treatment duration were also recorded. Patients were evaluated for appropriateness of switch according to set guidelines summarized from previously published data. 195 patients were divided into three groups depending on the quinolone prescribed. Patients were then divided into two groups: treatment and prophylaxis, in which there were 124 and 71 patients respectively. Only 54.8% were switched. 53.6% of patients not switched could have been eligible candidates for oral therapy. Mean time to switch was 4.7 days, 4.6 days, and 3.6 days for the ofloxacin, levofloxacin, and ciprofloxacin groups respectively. While the mean time to switch was similar in the three groups, ciprofloxacin patients had a slightly longer duration of treatment at home. Identification of hospitalized patients eligible for switch therapy should be a target for intervention to hospitals in effort to decrease cost.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-09-14T11:13:31Z
No. of bitstreams: 1
Maria_Homsi_Thesis.pdf: 30001366 bytes, checksum: 535f322ef902e03f25b86b1babb44f6c (MD5)
Made available in DSpace on 2011-09-14T11:13:31Z (GMT). No. of bitstreams: 1
Maria_Homsi_Thesis.pdf: 30001366 bytes, checksum: 535f322ef902e03f25b86b1babb44f6c (MD5)
1 bound copy: 64 p. available at RNL.
en
Antibiotics -- Therapeutic use
Antibiotics -- Physiological effect
Sequential therapy in patients receiving Fluoroquinolones at the American University of Beirut Medical Center. (c2001)
Thesis
Fall
Pharmacy
1975-11-09
199431620
Dr. Abdul-Rahman Bizri
Dr. Oussayma Moukhachen
Dr. Shihadeh Nayfeh
RA
Doctor of Pharmacy
Pharmacy
Dr. Gabriel Maliha
ORIGINAL
Maria_Homsi_Thesis_Redacted.pdf
Maria_Homsi_Thesis_Redacted.pdf
application/pdf
6237961
https://laur.lau.edu.lb:8443/bitstream/10725/560/3/Maria_Homsi_Thesis_Redacted.pdf
1c99d5510ce1aacaaebbc5578818a137
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/560/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/560
oai:laur.lau.edu.lb:10725/560
2017-09-25 10:06:57.162
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/6592019-09-11T07:06:29Zcom_10725_2058col_10725_2074
Alameddine, Yasmine
Geitany, Rouba
Afiouni, Fadi
2011-09-29T11:55:16Z
2011-09-29T11:55:16Z
2005
2011-09-29
2005-02-24
http://hdl.handle.net/10725/659
https://doi.org/10.26756/th.2005.35
Includes bibliographical references (leaves 15-17).
Purpose: The National Cholesterol Education Program (NCEP) III guidelines have been
hailed as an improvement in their potential to identify individuals at risk for coronary
heart disease (CHD) complications. Compared with the NCEP II, the new guidelines will
increase the number of patients who qualify for medical management. However, the
etIectiveness of these guidelines to identify young adults at risk for a cardiac event is yet
to be studied. The purpose of this study was to investigate the utility of the new NCEP III
guidelines in a group of young adults. Methods: A retrospective review of clinical data from young adults (age::; 55 years for
men and::; 65 years for women) hospitalized for acute myocardial infarction over a twoyear
period was conducted. Patients with a history of CHD or CHD equivalent were
excluded. Using the NCEP III guidelines, we calculated a lO-year risk for coronary
events on all patients. Results: A total of200 patients met criteria for inclusion. The mean age was 49 years
and 31 % were women. Mean lipid levels were all within the normal range, however, rates
of smoking and obesity were high. When the 10-year risk of these patients was stratified
by the number of risk factors and low-density lipoprotein cholesterol level, only 20% met
criteria to qualify for pharmacotherapy. Conclusion: The new guidelines offer multiple new features but have a tendency to
under appreciate the risk for disease in young adults. To improve performance in young
adults, statistical adjustments may be necessary.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-09-29T11:55:16Z
No. of bitstreams: 1
Yasmine_Alameddine_Thesis.pdf: 8239853 bytes, checksum: d5bbdd98f177d82ec85a38aba22c0178 (MD5)
Made available in DSpace on 2011-09-29T11:55:16Z (GMT). No. of bitstreams: 1
Yasmine_Alameddine_Thesis.pdf: 8239853 bytes, checksum: d5bbdd98f177d82ec85a38aba22c0178 (MD5)
1 bound copy: vi, 30 leaves; ill. (some col.); 31 cm. available at RNL.
en
Myocardial infarction -- Patients -- Lebanon
Myocardial infarction -- Prevention
Myocardial infarction -- Treatment
Hypercholesteremia -- Treatment
Hypercholesteremia -- Prevention
Cholesterol -- Treatment
Patient education
National cholesterol education panel III. (c2005)
performance in preventing myocardial infarction in young lebanese adults
Thesis
Spring
Pharmacy
OA
Doctor of Pharmacy
Pharmacy
Dr. Jean Dib
ORIGINAL
Yasmine_Alameddine_Thesis_Redacted.pdf
Yasmine_Alameddine_Thesis_Redacted.pdf
application/pdf
9464546
https://laur.lau.edu.lb:8443/bitstream/10725/659/3/Yasmine_Alameddine_Thesis_Redacted.pdf
cd237b2c8cdd29c72f5fb9171805cb11
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/659/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/659
oai:laur.lau.edu.lb:10725/659
2019-09-11 10:06:29.373
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/7182017-09-25T07:08:38Zcom_10725_2058col_10725_2074
Farah, Chantal Emile
2011-10-10T09:41:43Z
2011-10-10T09:41:43Z
1999
2011-10-10
1999-07-06
http://hdl.handle.net/10725/718
https://doi.org/10.26756/th.1999.8
Some abnormalities that occur in the fetus and the newborn are of genetic origin,
some result of an infection , some are due directly or indirectly to incidental
complications of pregnancy and in some cases the cause is unknown or due to
incorrect drug intake.
Women commonly ingest medications or drugs while pregnant; some of these
drugs may be teratogenic. Major malformations are usually the result of the first
trimester exposure during critical periods of organogenesis. Therefore, pregnant
women should be discouraged from taking Over-the-Counter drugs, and such
drugs should not be taken without counseling. For prescription drugs, risks versus
benefits should be taken into consideration by the physician. The safe use of a drug in a single pregnancy or even in a large number of
pregnancies does not assure that the drug is safe in all pregnancies. Very few
medicinal agents can be declared safe in pregnancy. Because any drug can be
teratogenic, it is important to develop effective methods to prevent fetal exposure.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-10-10T09:41:43Z
No. of bitstreams: 1
Chantal_Emile_Farah_Thesis.pdf: 93121161 bytes, checksum: c1f4e4a865ca4aa9af0952829a7d976d (MD5)
Made available in DSpace on 2011-10-10T09:41:43Z (GMT). No. of bitstreams: 1
Chantal_Emile_Farah_Thesis.pdf: 93121161 bytes, checksum: c1f4e4a865ca4aa9af0952829a7d976d (MD5)
1 bound copy: 121 p.; col. ill. available at RNL.
en
Fetus -- Effect of drugs on
Congenital toxoplasmosis
Toxoplasmosis
Drug receptors
The impact of drugs on congenital anomalies. (c1999)
Thesis
Summer I
Pharmacy
Dr. Nagi Al Hajj
RA
Doctor of Pharmacy
Pharmacy
Dr. Pascale Salameh
ORIGINAL
Chantal_Emile_Farah_Thesis_Redacted.pdf
Chantal_Emile_Farah_Thesis_Redacted.pdf
application/pdf
10358347
https://laur.lau.edu.lb:8443/bitstream/10725/718/3/Chantal_Emile_Farah_Thesis_Redacted.pdf
9ebf7b2072376abec6a033997e0a41ec
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/718/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/718
oai:laur.lau.edu.lb:10725/718
2017-09-25 10:08:38.411
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/7532020-04-30T09:33:27Zcom_10725_2058col_10725_2074
Sadek, Maha
2011-10-13T06:21:36Z
2011-10-13T06:21:36Z
1999
2011-10-13
1999-07-07
http://hdl.handle.net/10725/753
https://doi.org/10.26756/th.1999.10
Includes bibliographical reference (leaves 59-60).
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-10-13T06:21:36Z
No. of bitstreams: 1
Maha_Sadek_Thesis.pdf: 2632591 bytes, checksum: 710458e8bc3cf2e89be04b667347ec4b (MD5)
Made available in DSpace on 2011-10-13T06:21:36Z (GMT). No. of bitstreams: 1
Maha_Sadek_Thesis.pdf: 2632591 bytes, checksum: 710458e8bc3cf2e89be04b667347ec4b (MD5)
1 bound copy: iv, 60 leaves; 30 cm. available at RNL.
en
Hyperactive children
Attention-deficit hyperactivity disorder
Attention-deficit-disordered children
Attention-deficit hyperactivity disorder -- Treatment
An overview of Attention Deficit Hyperactivity Disorder. (c1999)
Thesis
Pharmacy
Dr. Shihadeh N. Nayfeh
Dr. Gabriel Maliha
RA
Doctor of Pharmacy
Pharmacy
Dr. Lydia Sholy
ORIGINAL
Maha_Sadek_Thesis_Redacted.pdf
Maha_Sadek_Thesis_Redacted.pdf
application/pdf
2620106
https://laur.lau.edu.lb:8443/bitstream/10725/753/3/Maha_Sadek_Thesis_Redacted.pdf
0899b7232c74c5e4cdf18e4222a6cf3c
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/753/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/753
oai:laur.lau.edu.lb:10725/753
2020-04-30 12:33:27.235
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/7572017-09-25T07:08:39Zcom_10725_2058col_10725_2074
Taissoun, Hala Issam
2011-10-13T08:53:24Z
2011-10-13T08:53:24Z
1999
2011-10-13
1999-07-07
http://hdl.handle.net/10725/757
https://doi.org/10.26756/th.1999.11
Background:
Bipolar disorder is a relatively common disorder and is characterized by
"unpredictable swings in mood from mania to depression".
Mania is a disease state which induces difficulties in work performance
and psychosocial functioning requiring rapid and effective treatment in
order to allow the patients to return to nonnal function.
It is a very serious illness characterized by a high rate of recurrence and a
deteriorating course.
The treatment of acute mania should not only be effective and well
tolerated but also anticipate and modify the future course of illness.
Lithium, anticonvulsants, antipsychotics and EeT are recognized
treatments for acute marna.
Although lithium is considered by most as the treatment of choice, the
position of anticonvulsants and EeT is currently gaining ground.
Objectives:
This study is aimed at determining which treatment is most adequate for
acute mania.
..... Each treatment modality will be discussed separately before comparing
the three strategies for efficacy, safety and time taken to achieve the goals
set.
Methods and data analysis:
All patients diagnosed with acute mama will be considered for this study.
A non-randomized, open-label, comparative study will be conducted in a
single center where patients will be assigned into three groups: the ones
receiving lithium, the ones on anticonvulsants( carbamazepine or
valproate) and fmally patients receiving EeT.
Treatments are given depending on the patients' physician.
All information concerning patients will be available through their files or medical records. The study data will be entered into a patient information database, using
the SPSS Data Entry Program.
Significance:
Different studies have been conducted lately comparing various
treatments of mania.
Most of these have come out with contradicting results. So the question
remains open as to which strategy should the first line treatment for acute
mama.
And because mania is such a severe disease with many complications, it
would be interesting to find the answer.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-10-13T08:53:24Z
No. of bitstreams: 1
Hala_Issam_Taissoun_Thesis.pdf: 2230206 bytes, checksum: f7897a328472b55578761991e8a9ba4b (MD5)
Made available in DSpace on 2011-10-13T08:53:24Z (GMT). No. of bitstreams: 1
Hala_Issam_Taissoun_Thesis.pdf: 2230206 bytes, checksum: f7897a328472b55578761991e8a9ba4b (MD5)
1 bound copy: xvii, 29, [5] l. available at RNL.
en
Manic-depressive illness -- Popular works
Mania -- Therapy
Treatment of acute Mania. (c1999)
A comparative study
Thesis
Summer I
Pharmacy
Dr. Akram Saab
RA
Doctor of Pharmacy
Pharmacy
Dr. Munir Khani
ORIGINAL
Hala_Issam_Taissoun_Thesis_Redacted.pdf
Hala_Issam_Taissoun_Thesis_Redacted.pdf
application/pdf
2225923
https://laur.lau.edu.lb:8443/bitstream/10725/757/3/Hala_Issam_Taissoun_Thesis_Redacted.pdf
a50e6e00891a7f1cd9a887a45e366673
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/757/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/757
oai:laur.lau.edu.lb:10725/757
2017-09-25 10:08:39.581
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/7692019-09-11T07:16:53Zcom_10725_2058col_10725_2074
Farchoukh, Lina
Haidar, Cyrine-Eliana
2011-10-13T12:23:17Z
2011-10-13T12:23:17Z
2003
2011-10-13
2003-07-03
http://hdl.handle.net/10725/769
https://doi.org/10.26756/th.2003.10
Includes bibliographical references (leaves 56-64).
OBJECTIVE: We assessed the safety and efficacy of a 1 a-day twice daily
rabeprazole-based triple therapy for Helicobacler pylori (H .pylon).
METHODS: H. pylori infected patients as confirmed by a rapid urease test
were enrolled in an outpatient based open-label prospective trial.
Symptomatic H. pylori infected patients were assigned to receive amoxicillin
1000 mg, clarithromycin 500 mg and rabeprazole 20 mg all twice daily for 10
days. No maintenance therapy was given during the follow up period. Patients
were followed up during therapy by telephone calls to assess compliance and
any occurrence of adverse effects. The efficacy endpoint was assessed by
using the 14_C urea breath test (UBT). Occurrence of side effects was also
evaluated. RESULTS: A total of 104 patients were analyzed per intention-to-treat (ITT)
and per-protocol (PP). Eradication rates of 87.5% (ITT) and 93.8% (PP) were
obtained. Therapy was relatively well tolerated with minimal side effects. CONCLUSION: Rabeprazole-based triple therapy is a suitable regimen for
eradication of H. pylori infection.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-10-13T12:23:17Z
No. of bitstreams: 1
Lina_Farchoukh_Thesis.pdf: 46819974 bytes, checksum: e1177800da1324c10862896ee5d3b3ab (MD5)
Made available in DSpace on 2011-10-13T12:23:17Z (GMT). No. of bitstreams: 1
Lina_Farchoukh_Thesis.pdf: 46819974 bytes, checksum: e1177800da1324c10862896ee5d3b3ab (MD5)
1 bound copy: xi, 64 leaves; ill. (some col.), map; 30 cm.; available at RNL.
en
Helicobacter pylori
Proton pump inhibitors
Safety and efficacy of a ten day helicobacter pylori eradication regimen with rabeprazole, amoxicillin and clarithromycin. (c2003)
Thesis
Summer I
Pharmacy
1978-08-28
199604220
Dr. Oussayma Moukhachen
Dr. Shihadeh Nayfeh
Dr. Assaad Soweid
OA
Doctor of Pharmacy
Pharmacy
Dr. Gabriel Maliha
ORIGINAL
Lina_Farchoukh_Thesis_Redacted.pdf
Lina_Farchoukh_Thesis_Redacted.pdf
application/pdf
5679121
https://laur.lau.edu.lb:8443/bitstream/10725/769/3/Lina_Farchoukh_Thesis_Redacted.pdf
948c8e51d5a6c7c890c705b4479c3eff
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/769/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/769
oai:laur.lau.edu.lb:10725/769
2019-09-11 10:16:53.229
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/7752017-09-25T07:08:40Zcom_10725_2058col_10725_2074
Domiati, Souraya
Hdeab, Fadi
2011-10-14T09:28:47Z
2011-10-14T09:28:47Z
1999
2011-10-14
1999-06
http://hdl.handle.net/10725/775
https://doi.org/10.26756/th.1999.12
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-10-14T09:28:46Z
No. of bitstreams: 1
Souraya_Domiati_Thesis.pdf: 41058426 bytes, checksum: 65d516fc4744fe3d5860e710ccdba787 (MD5)
Made available in DSpace on 2011-10-14T09:28:47Z (GMT). No. of bitstreams: 1
Souraya_Domiati_Thesis.pdf: 41058426 bytes, checksum: 65d516fc4744fe3d5860e710ccdba787 (MD5)
1 bound copy: 48 p. available at RNL.
en
Vitamins -- Physiological effect
Vitamin B12
Vitamin B-6
Coronary heart disease
The role of Homocysteine, Folic Acid, Vitamin B6, Vitamin B12 in development of coronary heart disease in Lebanon. (c1999)
Thesis
Pharmacy
Dr. Gabriel Maliha
Dr. Mona Osman
RA
Doctor of Pharmacy
Pharmacy
Dr. Mohamad Mroueh
ORIGINAL
Souraya_Domiati_Thesis_Redacted.pdf
Souraya_Domiati_Thesis_Redacted.pdf
application/pdf
5020687
https://laur.lau.edu.lb:8443/bitstream/10725/775/3/Souraya_Domiati_Thesis_Redacted.pdf
797d7022ac917751273a1f1fea2f0c3a
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/775/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/775
oai:laur.lau.edu.lb:10725/775
2017-09-25 10:08:40.127
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/7762017-09-25T07:08:40Zcom_10725_2058col_10725_2074
Tannous, Elias Fouad
2011-10-14T11:30:14Z
2011-10-14T11:30:14Z
2000
2011-10-14
2000-06-29
http://hdl.handle.net/10725/776
https://doi.org/10.26756/th.2000.6
Glibenclamide is a second generation sulfonylurea oral hypoglycemic agent
that plays an important role in the therapy of type II diabetes mellitus (DM-II);
moreover. glibenclamide (Glibamid®) is being extensively used among diabetics in
the middle east, including Lebanon where this drug is manufactured, without any
clinical in vivo implication showing or confirming its bioequivalency. So, this
investigation was carried out to evaluate the in vitro dissolution as well as the
bioavailability and pharmacokinetic properties of two tablet oral dosage forms of
glibenclamide, Daonil® (drug A) and Glibamid® (drug B) in a single dose of 5 mg
among healthy volunteers. The two products were found to comply with the compendial requirments for both
disintegration and content uniformity; moreover, the 111 vitro dissolution
characteristics of the two products were similar.
Method: Ten healthy male volunteers were enrolled in the study, each
received a single dose of each drug in an open randomizes two-way cross-over study,
with a wash out period of 7 days. Blood samples were obtained over a 10 hours
interval according to this fashion: At zero, 0.5, 1, 1.5, 2, 2.5 , 3, 4, 5, 6, 8, and 10
hours. These samples were analyzed for serum glucose by the glucose oxidase method
and glibenclamide by a sensitive HPLC assay. Results.· The two products were closely related in terms of their in vitro
compendial requirements. Moreover, there was no significant difference with respect
to peak serum concentration (103.92 ± 43.98 and 98.5 ± 51.26 nglml for products A
and B, respectively) or to the corresponding peak times (2.6 ± 0.66 and 2.3 ± 0.88
hours for A and B respectively) . Furthermore, the difference between area under
serum concentration-time curve (AUC) for the two products ( 390.86 ± 152.61 and
360.7 ± 160.21 ng hr Iml for A and B, respectively) was not statistically significant,
with P > 0.05. The comparable serum glucose levels for the two products supported
the pharmacodynamical equivalence between the two glibenclamide brands. Conclusion: The findings in this study indicates that the two products of
glibenclamide are bioequivalent in terms of bioavailability and pharmacodynamic
effect on healthy male volunteers.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-10-14T11:30:13Z
No. of bitstreams: 1
Elias_Fouad_Tannous_Thesis.pdf: 27529706 bytes, checksum: e74d75ef808f615637b135d3965ad077 (MD5)
Made available in DSpace on 2011-10-14T11:30:14Z (GMT). No. of bitstreams: 1
Elias_Fouad_Tannous_Thesis.pdf: 27529706 bytes, checksum: e74d75ef808f615637b135d3965ad077 (MD5)
1 bound copy: 27 p. available at RNL.
en
Glibenclamide
Diabetes Mellitus, Experimental
Diabetes Mellitus -- Drug therapy
A comparative single-dose bioequivalence study of two Glibenclamide brands among healthy volunteers. (c2000)
Thesis
Spring
Pharmacy
Dr. Mohamad Mroueh
Dr. Horatio Fung
RA
Doctor of Pharmacy
Pharmacy
Dr. Jean Dib
ORIGINAL
Elias_Fouad_Tannous_Thesis_Redacted.pdf
Elias_Fouad_Tannous_Thesis_Redacted.pdf
application/pdf
2548038
https://laur.lau.edu.lb:8443/bitstream/10725/776/3/Elias_Fouad_Tannous_Thesis_Redacted.pdf
caf3fda92ba7fbd33ce9720a648e426c
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/776/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/776
oai:laur.lau.edu.lb:10725/776
2017-09-25 10:08:40.16
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/7792017-09-25T07:08:40Zcom_10725_2058col_10725_2074
Cherfan, Antoine
2011-10-14T12:35:43Z
2011-10-14T12:35:43Z
2001
2011-10-14
2001-07-01
http://hdl.handle.net/10725/779
https://doi.org/10.26756/th.2001.18
The emergence of resistance among Streptococcus pneumoniae strains have led to
the development of several guidelines for the treatment of community-acquired
Pneumonia (CAP). Our purpose is to compare CAP empiric treatment practices
in patients hospitalized at a tertiary care medical center to those of the Infectious
Disease Society of America guidelines. In a six-month period, patients over 18
years of age were included in a prospective open label observational study if a
clinician documented an initial working diagnosis of pneumonia or if a chest xray
performed within the first 48 hours of hospitalization is reported consistent
with pneumonia. Patients were excluded if they were HIV positive, neutropenic,
had been hospitalized within the previous 10 days, had a history of organ transplant, had been exposed to chemotherapy or immunosuppressive therapy
within the previous two month, had been transferred from another acute care
facility. Hospitalization need per the Pneumonia Port criteria was evaluated; in
addition to the initial antimicrobial regimen, course of treatment, microbiology,
and outcome. Initial antimicrobial regimen was defined as all antibiotics used
during the first 48 hours of hospitalization. Outcome variables evaluated were
the length of stay, success or failure of therapy. Success of therapy was defined
as improvement in clinical or objective parameters. Failure was considered if the patient's antimicrobial regimen was changed or if there is clinical deterioration
from baseline.
65 eligible patients were identified with a mean age of 62.5 ± 18 years. 63 patients
were treated in the medical ward and two patients in the intensive care unit. Per
the pneumonia PORT prediction rule, there was overhospitalization by 50% .41
patients received single therapy regimen with Levofloxacin being the most used
single agent (51 %). The remaining 24 patients received combination therapy
primarily using a third generation cephalosporin (not Ceftazidime) with a
macrolide (75%). Success rate was 87.8% and 90.9% in single and combination
therapy groups respectively. Microbiological yield was very low for both sputum
and blood samples. In most of the cases, initial antibiotic regimen at AUBMC was appropriate and in
accordance with the IDSA guidelines. Special attention should be given to
decrease hospitalization rate, to preserve fluoroquinolones, and to improve
microbiological studies outcome.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-10-14T12:35:43Z
No. of bitstreams: 1
Antoine_Cherfan_Thesis.pdf: 61652832 bytes, checksum: 034eca51ea7241796e7854055a67d679 (MD5)
Made available in DSpace on 2011-10-14T12:35:43Z (GMT). No. of bitstreams: 1
Antoine_Cherfan_Thesis.pdf: 61652832 bytes, checksum: 034eca51ea7241796e7854055a67d679 (MD5)
1 bound copy: xi, 81 p. available at RNL.
en
Pneumonia
Antibiotics -- Therapeutic use
Empiric antibiotic therapy of community-acquired Pneumonia at the American University of Beirut Medical Center. (c2001)
Thesis
Summer I
Pharmacy
1978-02-25
199502890
Dr. Oussayma Moukhachen
Dr. Shihadeh Neyfeh
Dr. Abdul-Rahman Bizri
RA
Doctor of Pharmacy
Pharmacy
Dr. Gabriel Maliha
ORIGINAL
Antoine_Cherfan_Thesis_Redacted.pdf
Antoine_Cherfan_Thesis_Redacted.pdf
application/pdf
6892997
https://laur.lau.edu.lb:8443/bitstream/10725/779/3/Antoine_Cherfan_Thesis_Redacted.pdf
3a1b82cc226ab772aa7983900aabc0eb
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/779/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/779
oai:laur.lau.edu.lb:10725/779
2017-09-25 10:08:40.261
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/7922019-09-11T07:08:33Zcom_10725_2058col_10725_2074
Khatib, Zein Ahmad El-
2011-10-17T09:11:03Z
2011-10-17T09:11:03Z
2004
2011-10-17
2004-03
http://hdl.handle.net/10725/792
https://doi.org/10.26756/th.2004.20
Includes bibliographical references.
Background: Appropriate antibiotic prophylaxis can reduce the incidence of
surgical site infections (SSI) in many procedures. Although its role is still
controversial in a clean surgery such as cardiac, antibiotic prophylaxis has been
suggested by many guidelines to avoid the significant morbidity and mortality
precipitated by surgical site infections (superficial or deep, leg or sternal). Objectives: The main objective of this study is to evaluate the adherence to
rational antibiotic prophylaxis for Open heart surgery at AUB-MC with major
criteria being: antibiotic regimen, dose, timing, and duration. In addition, the
secondary objectives are to detect the surgical site infection incidence and to
identify potential risk factors for infection. Based on the results, recommendation
regarding the antibiotic prophylaxis will be made. Materials and Methods: All medical charts of patients undergoing Open heart
surgery between October 2002 and April 2003 at AUB-MC and satisfying the
inclusion criteria set for selection were reviewed retrospectively. The outcome
measures were all diagnosed surgical site infections whether superficial or deep,
leg or sternal. Results: One hundred fifty seven patients were included in the retrospective
analysis. All patients (100%) received antibiotic prophylaxis regardless of the
timing while only 38% received it 30-60 minutes prior to incision. Only 12% of
those fitting the criteria for an intraoperative dose did actually receive it. Concerning the duration of prophylaxis, around 15% of patients received up to 5
doses of prophylactic antibiotics post-operatively. The mean number of doses
received was 6 ±0.97 regardless of the antibiotic given. Concerning preoperative
agents given, cefuroxime alone was used in 74.5% of the cases, while
vancomycin alone was common in 5% of cases. The combination of both agents
was common in 7.64% of cases. The rest (11.46%) received no preoperative dose
at all. Postoperatively, the shares of cefuroxime, vancomycin, and their
combination among the population were 91.7%, 3.8%, 2.54% respectively. One
patient received cefazolin pre- and post-operatively. Only 2 patients (1.27%) had
surgical site infections; they were sternal infections occurring in non smoker
elderly male patients undergoing CABO and having no known risk factors for
infections at all. Both received cefuroxime pre and postoperatively for 6 doses but no intraoperative antibiotics although their operations lasted for more than 2
hours each (135 min vs 210 min). The added hospital stay was 3 days for one
patient and 4 days for the other. One patient had a wound cultured and revealed
Pseudomonal growth. Both patients were discharged on antibiotics. Conclusion: Antibiotic prophylaxis in cardiac surgery is a common routine
practiced by doctors at AUB-MC. However, there was a trend towards extended
prophylaxis and excessive use of cefuroxime. The low number of patients
acquiring a surgical site infection (2 patients) at AUB-MC can't allow significant
findings and thus hinders further recommendation concerning the practice.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-10-17T09:11:03Z
No. of bitstreams: 1
Zein_Ahmad_El_Khatib_Thesis.pdf: 23157573 bytes, checksum: 018c2b52d2e91cbb80e73e0a85b97194 (MD5)
Made available in DSpace on 2011-10-17T09:11:03Z (GMT). No. of bitstreams: 1
Zein_Ahmad_El_Khatib_Thesis.pdf: 23157573 bytes, checksum: 018c2b52d2e91cbb80e73e0a85b97194 (MD5)
1 bound copy: xi, 45 leaves; ill. (some col.); 30 cm. available at RNL.
en
Antibiotics -- Therapeutic use
Surgical wound infections -- Prevention
Medicine, Preventive
Evaluation of antibiotic prophylaxis and factors affecting the incidence of surgical site infections in cardiac surgery at a tertiary medical center in Lebanon. (c2004)
Thesis
Spring
Pharmacy
1977-01-21
199406940
Dr. Oussayma Moukhachen
OA
Doctor of Pharmacy
Pharmacy
Dr. Abdul Rahman Bizri
ORIGINAL
Zein_Ahmad_El_Khatib_Thesis_Redacted.pdf
Zein_Ahmad_El_Khatib_Thesis_Redacted.pdf
application/pdf
3726790
https://laur.lau.edu.lb:8443/bitstream/10725/792/3/Zein_Ahmad_El_Khatib_Thesis_Redacted.pdf
b3a3ca07750193c5e365dc63cf7c0bef
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/792/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/792
oai:laur.lau.edu.lb:10725/792
2019-09-11 10:08:33.452
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/8332019-09-11T07:02:54Zcom_10725_2058col_10725_2074
Abdel-Rahman, Maya O.
Reda, Maya T.
2011-10-20T11:34:23Z
2011-10-20T11:34:23Z
2004
2011-10-20
2004-06-28
http://hdl.handle.net/10725/833
https://doi.org/10.26756/th.2004.28
Includes bibliographical references (leaves 26-31).
This thesis is a retrospective study on 300 medical records between January 2003 and
June 2003 in Makassed General Hospital (MGH). The objective of this study is to
determine if tropisetron use at MGH was appropriate, and if not, determine possible
interventions for cost savings. The results showed a significant tropisetron overuse,
which can be prevented by targeted interventions like seminars or pre-printed protocols
for both nurses and medical doctors.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-10-20T11:34:23Z
No. of bitstreams: 1
Maya_O_Abdel_Rahman_Thesis.pdf: 964365 bytes, checksum: 5dafe845bde1bce7086de255d26de80a (MD5)
Made available in DSpace on 2011-10-20T11:34:23Z (GMT). No. of bitstreams: 1
Maya_O_Abdel_Rahman_Thesis.pdf: 964365 bytes, checksum: 5dafe845bde1bce7086de255d26de80a (MD5)
1 bound copy: vii, 31 leaves; 30 cm. available at RNL.
en
Cancer -- Chemotherapy -- Complications
Antineoplastic agents -- Side effects
Antiemetics -- Therapeutic use
Chemotherapy -- Case studies
Nausea -- Prevention and control
Vomiting -- Prevention and control
Utilization and cost evaluation of tropisetron use for CINV. (c2004)
Thesis
Spring
Pharmacy
1980-02-03
199701890
OA
Doctor of Pharmacy
Pharmacy
Professor Shireen Nabhani
ORIGINAL
Maya_O_Abdel_Rahman_Thesis_Redacted.pdf
Maya_O_Abdel_Rahman_Thesis_Redacted.pdf
application/pdf
1000545
https://laur.lau.edu.lb:8443/bitstream/10725/833/3/Maya_O_Abdel_Rahman_Thesis_Redacted.pdf
2e2ed40e31d60d1c03b057f28ec6a195
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/833/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/833
oai:laur.lau.edu.lb:10725/833
2019-09-11 10:02:54.819
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/9992017-09-25T07:08:46Zcom_10725_2058col_10725_2074
Haddad, Rana
2011-11-17T11:53:13Z
2011-11-17T11:53:13Z
1999
2011-11-17
1999-07
http://hdl.handle.net/10725/999
https://doi.org/10.26756/th.1999.14
The clinical use of assisted reproductive techniques nowadays is intimately
dependent on the use of controlled ovarian hyperstimulation. Ovarian
hyperstimulation with Gonadotropin Releasing Hormone analogues (GnRHa)
suppression of endogenous gonadotropin activity, and with Human Menopausal
Gonadotropin (HMG) or FSH monotherapy is commonplace in Vitro Fertilization
Programs (IVF). FSH monotherapy includes purified FSH, highly purified FSH and recombinant FSH. Although the treatment outcome has a significant percentage of success, its process is often a heavy strain on the couples. The objective of the study is to examine the physical and psychological changes associated with controlled ovarian hyperstimulation in women undergoing assisted reproductive techniques. A prospective study will be performed at AUH, Assisted Reproductive Technology Unit. The data will be collected from the charts of the patients who presented to the clinic and have been evaluated to receive the treatment for induction of ovulation. A special questionnaire is designed for the gathering of the data. Results will be withdrawn and evaluated through a special program SPSS with the, assistance of a biostatistician. The patients will be evaluated for the adverse effects associated with the treatment and for the anxiety accompanied by it. Patients
assessment and personal acceptance of the treatment will be also evaluated ...
The study will give us an idea about the physical and psychological changes that
accompany the controlled ovarian hyperstimulation in women undergoing assisted
reproductive techniques.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-11-17T11:53:13Z
No. of bitstreams: 1
Rana_Haddad_Thesis.pdf: 1691295 bytes, checksum: ce4a57737c03c2610cf0a619b186ddde (MD5)
Made available in DSpace on 2011-11-17T11:53:13Z (GMT). No. of bitstreams: 1
Rana_Haddad_Thesis.pdf: 1691295 bytes, checksum: ce4a57737c03c2610cf0a619b186ddde (MD5)
1 bound copy: xi, 54 p. Available at RNL.
en
Infertility, Female
Physical & psychological changes associated with controlled Ovarian Hyperstimulation in women undergoing assisted reproductive techniques. (c1999)
Thesis
Summer I
Pharmacy
Dr. Shehadeh Nayfeh
RA
Doctor of Pharmacy
Pharmacy
Dr. Lydia Sholy
ORIGINAL
Rana_Haddad_Thesis_Redacted.pdf
Rana_Haddad_Thesis_Redacted.pdf
application/pdf
1667140
https://laur.lau.edu.lb:8443/bitstream/10725/999/3/Rana_Haddad_Thesis_Redacted.pdf
5786a8ee60be68fc617959870a3c58d3
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/999/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/999
oai:laur.lau.edu.lb:10725/999
2017-09-25 10:08:46.924
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/10032017-09-25T07:08:47Zcom_10725_2058col_10725_2074
Jabre, Mazen Gerges
2011-11-17T12:42:53Z
2011-11-17T12:42:53Z
2000
2011-11-17
2000-06
http://hdl.handle.net/10725/1003
https://doi.org/10.26756/th.2000.10
Parkinson's disease (PO) is a neurodegerative disorder predominantly characterized
by the progressive loss of dopaminergic cells in the substantia nigra pars compacta
(SNPC). Striatal dopamine concentration gets significantly reduced, and clinical
symptoms, especially the motor handicap, prevail. The management of this disease is symptomatic, mainly based on the use of levodopa.
Due to the high incidence of adverse effects associated with its chronic use,
alternative treatments based on the direct-acting dopamine agonists have been used.
Deep brain stimulation has been proposed as an alternative effective treatment for
advanced PO cases disabled by the high incidence of levodopa-induced motor
complications. High frequency stimulation of the subthalamic nucleus (STN HFS) alleviated the
severe motor disabilities associated with PO; however, a postoperative ,
pharmacological strategy has not been established yet. The following study reports
and investigates the efficacy, safety and tolerability of a postoperative therapeutic
approach mainly based on dopamine agonists. We run a pilot, prospective, and open-label study on five patients with severe
idiopathic PO who underwent STN HFS. Their postoperative management mainly
consisted of dopamine agonist, while levodopa was considered as a rescue therapy.
Efficacy, safety and tolerability outcome measures were determined 12 weeks after surgery using the Unified Parkinson's Disease Rating Scale motor part (UPDRS-III),
UPDRS part IV (complications of therapy) and the Hoehn and Yahr staging scale.
Three months after surgery, all patients were effectively maintained on dopamine
agonist-based therapy with an 88% improvement in UPDRS motor subscore (p
<0.01). Dyskinesias, motor fluctuations, and levodopa-equivalent daily dose
requirements decreased by 82.35%,82.14%, and 77%, respectively (p<O.OI). The
mean levodopa dose was reduced by 90% (p < 0.01), while the mean dopamine
agonist dose was increased by 15% from preoperative level. Reported adverse events
were mild and transient. Our preliminary study suggests that STN HFS is a safe and effective approach in the treatment of advanced PD. Postoperative dopamine agonist monotherapy can
potentially be proposed in controlling residual motor disability before adding levodopa.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2011-11-17T12:42:53Z
No. of bitstreams: 1
Mazen_Gerges_Jabre_Thesis.pdf: 59959191 bytes, checksum: 3526db57b78893541ae3a09f8a7ccdc1 (MD5)
Made available in DSpace on 2011-11-17T12:42:53Z (GMT). No. of bitstreams: 1
Mazen_Gerges_Jabre_Thesis.pdf: 59959191 bytes, checksum: 3526db57b78893541ae3a09f8a7ccdc1 (MD5)
1 bound copy: 76 p. Available at RNL.
en
Dopamine -- Agonists -- Therapeutic use -- Testing
Parkinson's disease
The effect of Dopamine Agonists on patients with advanced Parkinson's disease subjected to subthalamic deep brain stimulation. (c2000)
Thesis
Spring
Pharmacy
199231340
Dr. Kamal Kallab
RA
Doctor of Pharmacy
Pharmacy
Dr. Boulos-Paul Bejjani
ORIGINAL
Mazen_Gerges_Jabre_Thesis_Redacted.pdf
Mazen_Gerges_Jabre_Thesis_Redacted.pdf
application/pdf
7039311
https://laur.lau.edu.lb:8443/bitstream/10725/1003/3/Mazen_Gerges_Jabre_Thesis_Redacted.pdf
a79b9a67050a25e847edf8e64dcd0a24
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/1003/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/1003
oai:laur.lau.edu.lb:10725/1003
2017-09-25 10:08:47.022
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/14002017-09-25T07:10:07Zcom_10725_2058col_10725_2074
Saade, Sarita Georges
2012-12-05T12:49:07Z
2012-12-05T12:49:07Z
2003
2012-12-05
2003-08-25
http://hdl.handle.net/10725/1400
https://doi.org/10.26756/th.2003.13
Includes bibliographical references (leaves 190-257).
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2012-12-05T12:49:07Z
No. of bitstreams: 1
Sarita_Georges_Saade_Thesis.pdf: 14044265 bytes, checksum: 2020923cdff661148415e5e9f9f504b3 (MD5)
Made available in DSpace on 2012-12-05T12:49:07Z (GMT). No. of bitstreams: 1
Sarita_Georges_Saade_Thesis.pdf: 14044265 bytes, checksum: 2020923cdff661148415e5e9f9f504b3 (MD5)
1 bound copy: xiii, 257 leaves; ill.; 30 cm. available at RNL.
en
Cytochrome P-450
Drugs -- Metabolism
Cytochrome P450 2D6 polymorphism in Lebanon. (c2003)
Thesis
Summer II
Pharmacy
OA
Doctor of Pharmacy
Pharmacy
Dr. Mohammad Mroueh
ORIGINAL
Sarita_Georges_Saade_Thesis_Redacted.pdf
Sarita_Georges_Saade_Thesis_Redacted.pdf
application/pdf
14082908
https://laur.lau.edu.lb:8443/bitstream/10725/1400/3/Sarita_Georges_Saade_Thesis_Redacted.pdf
f2aa55fc1dec3499b2921e7c5f09ec8a
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/1400/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/1400
oai:laur.lau.edu.lb:10725/1400
2017-09-25 10:10:07.798
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/14042017-09-25T07:10:07Zcom_10725_2058col_10725_2074
Hamra, Rasha Saadi
2012-12-06T12:31:40Z
2012-12-06T12:31:40Z
2003
2012-12-06
2003-09-16
http://hdl.handle.net/10725/1404
https://doi.org/10.26756/th.2003.14
Background: Appropriate antibiotic prophylaxis can reduce the incidence of surgical site infections (55I) in many procedures. Its role in acutely inflamed appendicitis remains controversial. Complicated appendicitis is frequently associated with superlative complications. Objectives: The objective is to evaluate the appropriateness of antibiotic prophylaxis in patients undergoing appendectomy at a tertiary care medical center; to assess the antibiotic choice, timing, and duration of administration; and to determine the impact and the value of intraoperative cultures on the selection of antibiotics. Material and Methods: The medical charts of patients with a positive pathology for acute, gangrenous or perforated appendicitis who underwent appendectomy between January l, 1999 and April 30, 2001 at American University of Beirut Medical Center (AUBMC), were retrospectively reviewed. Results: 99% of patients received antibiotic prophylaxis. 37% of cases received their preoperative prophylactic dose at 30-60 minutes before incision. 73% of patients who had acute appendicitis received prophylactic antibiotics for more than 24 hours. The most common regimen used preoperatively was amoxicillin/clavulanic acid while the triple regimen was the most frequently used postoperatively. 7%, of the study population, developed surgical site infection (SSI); all had emergency appendectomy, and 71% received inappropriate preoperative prophylaxis. Other contributing factors to the development of SSI were found to be the pathological state of the appendix, open surgical procedure, and pediatric age group. The mean added hospital stay for patients with SSI was 5 days per patient. 47% received oral antibiotics upon discharge. The most common organism isolated intraoperative was Escherichia coli in 70% of cases followed by Enterococci in 19% and Pseudomonas aeruginosa in 7.5%; no anaerobes were isolated. There was a 5% change in antibiotic regimen following the results of intraoperative cultures. Conclusion: Antibiotic prophylaxis is widely used in appendectomy with tendency towards long courses. It is an effective modality of reducing SS! if applied appropriately. Inappropriate prophylaxis, emergency surgery, open procedures, complicated appendicitis, and pediatric patients are major contributing factors to development of SSI. Intraoperative culture results did not significantly influence antibiotic therapy.
Submitted by Rana Najjar (rnajjar@lau.edu.lb) on 2012-12-06T12:31:40Z
No. of bitstreams: 1
Rasha_Saadi_Hamra_Thesis.pdf: 9300229 bytes, checksum: 9f1ec0bbfcc775b0b379705aa984469e (MD5)
Made available in DSpace on 2012-12-06T12:31:40Z (GMT). No. of bitstreams: 1
Rasha_Saadi_Hamra_Thesis.pdf: 9300229 bytes, checksum: 9f1ec0bbfcc775b0b379705aa984469e (MD5)
1 bound copy: vii, 24 p.; 30 cm. available at RNL.
en
Antibiotics -- Therapeutic use
Medicine, Preventive
Evaluation of antibiotic prophylaxis and other factors affecting the incidence of surgical site infection in appendectomy at a tertiary medical center in Lebanon. (c2003)
Thesis
Summer II
Pharmacy
Dr. Abdul Rahman Bizri
OA
Doctor of Pharmacy
Pharmacy
Dr. Jean Dib
ORIGINAL
Rasha_Saadi_Hamra_Thesis_Redacted.pdf
Rasha_Saadi_Hamra_Thesis_Redacted.pdf
application/pdf
9715297
https://laur.lau.edu.lb:8443/bitstream/10725/1404/3/Rasha_Saadi_Hamra_Thesis_Redacted.pdf
aca7dda8520b7d15bf8d1dcc9f4f4b56
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1682
https://laur.lau.edu.lb:8443/bitstream/10725/1404/2/license.txt
d0b1b017acd557b38eb6eb299413f103
MD5
2
10725/1404
oai:laur.lau.edu.lb:10725/1404
2017-09-25 10:10:07.895
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/64412021-03-19T10:03:26Zcom_10725_2058col_10725_2074
Doumit, Rita
2017-10-30T13:17:42Z
2017-10-30T13:17:42Z
2012
2017-10-30
http://hdl.handle.net/10725/6441
Doumit, R. (2012). Coping mechanisms among Lebanese first-time college students (Doctoral dissertation, Loyola University Chicago).
Chicago
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://search.proquest.com/docview/1081486651?pq-origsite=gscholar
Background: Newly admitted college students are subject to a massive input of
stresses which require successful and ever-changing coping strategies. An expanding
body of literature suggests that inadequate responses to coping with stress in adolescents
of college age contributes to a range of psychosocial problems, including poor academic
performance, anxiety, depression, mental distress and eating disorders. Those problems
may be further exacerbated for adolescents who live in countries plagued by the
uncertainties of war and violence.
Significance: The concept of coping is of particular interest in Lebanon given the
socio-cultural context in which Lebanese youth pursuit their education and social
activities.
Methods: A descriptive correlational cross-sectional design was used to explore
the relationships of stress, uncertainty, resilience, religiosity, socioeconomic status, social
support to coping and well-being in Lebanese newly admitted college students. The
Seiffge-Krenke’s Stress, Coping and Outcomes Model (1995) was used as the conceptual
framework for this descriptive cross-sectional correlational study. A convenient study
sample of 293 newly admitted college students were recruited at the Lebanese American
University on the Beirut campus. Data was gathered from self-reported questionnaires.
Results: Results demonstrated that Lebanese first-time college students used a
combination of internal, active and withdrawal coping strategies as anticipated. Strategies
xiv
used varied with the type of situation. A greater proportion of overall strategies used
included active and internal coping strategies which were focused on resolving the issue
or problem. Stress (r= -.547, p < .01) had the highest correlation with well-being
followed by social support (r= .377, p < .01), resilience (r = .366, p < .01), uncertainty (r=
-.353, p < .01), withdrawal coping (r = -.243, p < .01), and gender (p < .01) as a
controlling variable. When all those factors were combined together, six variables in
addition to gender accounted for significant increments of variance in the level of wellbeing.
These six variables included stress related to self, resilience, uncertainty, social
support, religiosity, withdrawal coping and gender. As scores on resilience, social support
and being male increased, the well-being of Lebanese first-time College students also
increased. As the usage of withdrawal coping strategies, being exposed to stress related to
self and uncertainty increased, the well-being of Lebanese first-time college students
decreased. The final regression model accounted for 54% of the variance in well-being
level (52.7% adjusted) (p < .001). The result of the mediation analysis showed that
coping did not mediate the relationship between stress and well-being.
Implications for Nursing Practice and Research: The results of this study will
provide a better understanding of factors that are predictive of decreased well-being in
Lebanese first-time college students and will be valuable in developing culturally
sensitive intervention of stress and coping management program with a surveillance
system and a systematic planning and evaluation procedure to respond to emerging and
changing students’ needs at the Lebanese American University.
Submitted by Rola Habre (rola.habre@lau.edu.lb) on 2017-10-30T13:17:42Z
No. of bitstreams: 1
Coping.pdf: 3643075 bytes, checksum: bc10c01f2c038250d17cb8fe8420443e (MD5)
Made available in DSpace on 2017-10-30T13:17:42Z (GMT). No. of bitstreams: 1
Coping.pdf: 3643075 bytes, checksum: bc10c01f2c038250d17cb8fe8420443e (MD5)
N/A
Includes bibliographical references
en
Coping mechanisms among Lebanese first-time college students
Thesis
PHD
SON
200200810
N/A
Velsor-Friedrich, Barbara
rita.doumit@lau.edu.lb
Lebanese American University
https://orcid.org/0000-0003-1374-2751
Loyola University Chicago
ORIGINAL
Coping.pdf
Coping.pdf
application/pdf
3643075
https://laur.lau.edu.lb:8443/bitstream/10725/6441/1/Coping.pdf
bc10c01f2c038250d17cb8fe8420443e
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1741
https://laur.lau.edu.lb:8443/bitstream/10725/6441/2/license.txt
bbdf057ac9b0ba096f7407990ff44747
MD5
2
10725/6441
oai:laur.lau.edu.lb:10725/6441
2021-03-19 12:03:26.295
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/68232021-03-19T10:43:11Zcom_10725_2058col_10725_2074
AbouAntoun, Thamara Jihad
2017-12-18T10:23:04Z
2017-12-18T10:23:04Z
2008
2017-12-18
http://hdl.handle.net/10725/6823
AbouAntoun, T. J. (2008). Investigating the mechanism by which the platelet-derived growth factor receptor promotes metastasis in medulloblastoma (Doctoral dissertation, The George Washington University).
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://search.proquest.com/docview/193997870?accountid=27870
Expression of the platelet-derived growth factor receptor (PDGFR) correlates with metastatic medulloblastoma and PDGF treatment of medulloblastoma cells activates the pro-survival and pro-migratory pathways downstream of the receptor, for instance, increases extra-cellular regulated kinase (Erk1/2), Protein kinase B (Akt) and phosphatidylinositide 3-kinase (PI3K) activity and decreases phosphatase and tensin homolog (PTEN) expression and activity. PDGFR can also heterodimerize with and transactivate the epidermal growth factor receptor (EGFR). Our overarching hypothesis was to determine whether targeting PDGFR activity effectively inhibits signaling required for medulloblastoma cell migration and invasion and whether it blocks PDGFR-induced transactivation of EGFR. To explore this we used Daoy and D556 human medulloblastoma cells which we transfected with small interfering RNA (siRNA) to PDGFRβ or treated with either Imatinib mesylate (Gleevec®) or Sunitib Malate (SUTENT®), specific inhibitors of PDGFR, to block PDGFR expression and activity, respectively. Cell migration, survival and PDGFR signaling following PDGF-BB stimulation of serum-depleted cells, with and without PDGFR inhibition, was measured. PDGF-BB treatment of cells enhanced migration and proliferation after 24 hr; increased PDGFRβ, PI3K, Akt and Erk1/2 activity, decreased PTEN activation and transactivated EGFR. Imatinib (1 uM) treatment of PDGFRβ active cells induced apoptosis at 72 hr and inhibited migration at 24 hr and invasion at 48 hr after a single dose and concomitantly inhibited PDGF-BB activation of PDGFRβ, PI3K, Akt and Erk1/2 but promoted PTEN activity. SUTENT (0.2 uM) treatment similarly inhibited short (4 hr) and long-term (24 hr) cell migration and cell invasion. PDGF-BB activation of PDGFRβ, PI3K, Akt and Erk1/2 was simultaneously inhibited by SUTENT treatment, while PTEN activity was promoted, without any affect on apoptosis. siRNA silencing of PDGFRβ similarly inhibited survival, migration and signaling and both siRNA and Imatinib or SUTENT treatment inhibited PDGF-BB-induced EGFR trans-activation. Inhibition of PDGFRβ in medulloblastoma cells by siRNA or drug treatment effectively blocked PDGFRβ signaling and EGFR transactivation and concomitantly inhibited cell migration and invasion. These results indicate that PDGFRβ tyrosine kinase activity is critical for survival and migration/invasion of medulloblastoma cells, in part by decreasing PTEN activity and transactivating EGFR, and thus may represent an important therapeutic target for this disease.
Submitted by Rola Habre (rola.habre@lau.edu.lb) on 2017-12-18T10:23:04Z
No. of bitstreams: 1
Investigating.pdf: 61318756 bytes, checksum: 48e3bed507936cd439c96260abf2c4e4 (MD5)
Made available in DSpace on 2017-12-18T10:23:04Z (GMT). No. of bitstreams: 1
Investigating.pdf: 61318756 bytes, checksum: 48e3bed507936cd439c96260abf2c4e4 (MD5)
N/A
en
Investigating the mechanism by which the platelet-derived growth factor receptor promotes metastasis in medulloblastoma
Thesis
PHD
SOP
201005279
Pharmaceutical Sciences Department
MAcDonald, Tobey J.
tamara.abouantoun@lau.edu.lb
Lebanese American University
Health and environmental sciences
Biological sciences
EGFR
Medulloblastoma
Metastasis
Platelet-derived growth factor
George Washington University
ORIGINAL
Investigating.pdf
Investigating.pdf
application/pdf
61318756
https://laur.lau.edu.lb:8443/bitstream/10725/6823/1/Investigating.pdf
48e3bed507936cd439c96260abf2c4e4
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1741
https://laur.lau.edu.lb:8443/bitstream/10725/6823/2/license.txt
bbdf057ac9b0ba096f7407990ff44747
MD5
2
10725/6823
oai:laur.lau.edu.lb:10725/6823
2021-03-19 12:43:11.389
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/97132021-09-20T10:30:33Zcom_10725_2058col_10725_2074
Ammous, Saifedean H.
2018-11-07T07:57:57Z
2018-11-07T07:57:57Z
2011
2018-11-07
http://hdl.handle.net/10725/9713
Ammous, S. H. (2011). Alternative Energy Science and Policy: Biofuels as a Case Study (Doctoral dissertation, Columbia University).
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://papers.ssrn.com/Sol3/papers.cfm?abstract_id=2832730
This dissertation studies the science and policy-making of alternative energy using biofuels as a case study, primarily examining the instruments that can be used to alleviate the impacts of climate change and their relative efficacy. Three case studies of policy-making on biofuels in the European Union, United States of America and Brazil are presented and discussed. It is found that these policies have had large unintended negative consequences and that they relied on Lifecycle Analysis studies that had concluded that increased biofuels production can help meet economic, energy and environmental goals. A close examination of these Lifecycle Analysis studies reveals that their results are not conclusive. Instead of continuing to attempt to find answers from Lifecycle Analyses, this study suggests an alternative approach: formulating policy based on recognition of the ignorance of real fuel costs and pollution. Policies to combat climate change are classified into two distinct approaches: policies that place controls on the fuels responsible for emissions and policies that target the pollutants themselves. A mathematical model is constructed to compare these two approaches and address the central question of this study: In light of an ignorance of the cost and pollution impacts of different fuels, are policies targeting the pollutants themselves preferable to policies targeting the fuels? It is concluded that in situations where the cost and pollution functions of a fuel are unknown, subsidies, mandates and caps on the fuel might result in increased or decreased greenhouse gas emissions; on the other hand, a tax or cap on carbon dioxide results in the largest decrease possible of greenhouse gas emissions. Further, controls on greenhouse gases are shown to provide incentives for the development and advancement of cleaner alternative energy options, whereas controls on the fuels are shown to provide equal incentives to the development of cleaner and dirtier alternative fuels. This asymmetry in outcomes — regardless of actual cost functions — is the reason why controls on greenhouse gases are deemed favorable to direct fuel subsidies and mandates.
Submitted by Zeina Saghir (zeina.saghir@lau.edu.lb) on 2018-11-07T07:57:56Z
No. of bitstreams: 1
Alternative.pdf: 1465259 bytes, checksum: 2615f2bde0ca432e2a62bc8c002567dd (MD5)
Made available in DSpace on 2018-11-07T07:57:57Z (GMT). No. of bitstreams: 1
Alternative.pdf: 1465259 bytes, checksum: 2615f2bde0ca432e2a62bc8c002567dd (MD5)
N/A
viii, 215 leaves : ill.
Includes bibliographical references.
en
Alternative energy science and policy
biofuels as a case study
Thesis
PhD
SOB
200905039
Economics
Mutter, John Colin
saifedean.ammous@lau.edu.lb
Lebanese American University
Biofuels
Ethanol
Biodiesel
Cellulosic Ethanol
Policy
Climate Change
Global Warming
Columbia University
ORIGINAL
Alternative.pdf
Alternative.pdf
application/pdf
1465259
https://laur.lau.edu.lb:8443/bitstream/10725/9713/1/Alternative.pdf
2615f2bde0ca432e2a62bc8c002567dd
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1741
https://laur.lau.edu.lb:8443/bitstream/10725/9713/2/license.txt
bbdf057ac9b0ba096f7407990ff44747
MD5
2
10725/9713
oai:laur.lau.edu.lb:10725/9713
2021-09-20 13:30:33.298
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/114482021-03-19T10:47:38Zcom_10725_2058col_10725_2074
Milane, Aline
2019-10-15T09:02:08Z
2019-10-15T09:02:08Z
2009
2019-10-15
http://hdl.handle.net/10725/11448
Milane, A. (2009). Impact des pompes d'efflux (abcb1 et abcg2) de la barrière hémato-encéphalique sur le passage cérébral du riluzole et de la minocycline: application à la sclérose latérale amyotrophique (Doctoral dissertation, Paris 11).
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://www.theses.fr/2009PA114801
La sclérose latérale amyotrophique (SLA) est une maladie neurodégénérative fatale. Le seul traitement ayant reçu l'AMM est le riluzole (RLZ). La minocycline (MNC) a montré être neuroprotectrice dans un modèle murin de SLA. L'objectif de ce travail a été d'explorer le passage cérébral du RLZ et de la MNC et plus particulièrement les mécanismes d'efflux médiés par les transporteurs ABC: la P-gp et la BCRP. Nous avons aussi exploré l'intéraction médicamenteuse entre RLZ et MNC. Nos essais ont montré que le RLZ et la MNC sont transportés par la P-gp et que le RLZ est aussi transporté par la BCRP. La MNC est inhibitrice de la P-gp et potentialise ainsi le passage intracérébral du RLZ qui lui a montré pouvoir induire la BCRP. Sur un modèle murin de SLA, l'expression cérébrale de la P-gp est induite et les concentrations cérébrales en RLZ sont plus faibles. Ces études devraient, être intégrées en préclinique, quand une association médicamenteuse est envisagée.
Submitted by Rola Habre (rola.habre@lau.edu.lb) on 2019-10-15T09:02:08Z
No. of bitstreams: 0
Made available in DSpace on 2019-10-15T09:02:08Z (GMT). No. of bitstreams: 0
N/A
Includes bibliographical references
fr
Impact des pompes d'efflux (abcb1 et abcg2) de la barrière hémato-encéphalique sur le passage cérébral du riluzole et de la minocycline
application à la sclérose latérale amyotrophique
Thesis
Doctor of Pharmacy
SOP
200904164
Pharmaceutical Sciences
Farinotti, Robert
aline.milane@lau.edu.lb
Lebanese American University
Riluzole
Minocycline
Barrière hémato-encéphalique
Sclérose latérale amyotrophique
P-glycoprotéine
Bcrp
Sclérose latérale amyotrophique
Barrière hématoencéphalique
https://orcid.org/0000-0002-3159-6578
pharmacie (Châtenay-Malabry, Hauts-de-Seine)
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1741
https://laur.lau.edu.lb:8443/bitstream/10725/11448/1/license.txt
bbdf057ac9b0ba096f7407990ff44747
MD5
1
10725/11448
oai:laur.lau.edu.lb:10725/11448
2021-03-19 12:47:38.112
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/134442022-07-14T07:48:12Zcom_10725_2058col_10725_2074
Al Shaikhly, Raya
2022-04-05T11:32:33Z
2022-04-05T11:32:33Z
2021
2021-01-01
http://hdl.handle.net/10725/13444
https://doi.org/10.26756/th.2022.337
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Insulin resistance and compensatory hyperinsulinemia have been proposed as potential mechanisms for the gonadotropin secretory abnormalities characteristic of PCOS. Thus, metformin, an insulin-lowering agents, has been prescribed extensively to regulate insulin level of patients with PCOS. However, there are individual differences in the treatment effectiveness of metformin among PCOS patients. The exact mechanism of insulin resistance remains to be clarified; however, it is supposed that it originates from the post-receptor defects. The insulin receptor substrate-1 (IRS1) is an important intermediate in insulin signaling pathway.
Polymorphisms in IRS1 have been associated with insulin resistance. Respectively, in this study, we investigated the effect of the polymorphisms of IRS1 on the treatment effectiveness of metformin in PCOS patients. The study involved 100 women diagnosed with PCOS according to Rotterdam criteria and 100 control healthy women. All patients diagnosed with PCOS received 500 mg twice daily for 12 weeks. Both case and control group were genotyped for the single nucleotide polymorphisms (SNPs) (rs1801123) of IRS.1.Main outcome measures were hormonal parameters, metabolic parameters, and lipid panel parameters. They were measured at baseline for control and PCOS group and 12 weeks post metformin treatment for PCOS patients only.Our study has shown that metformin had differential effects on fasting insulin level, HbA1C, LH, LH/FSH ratio, testosterone (p-value<0.05)among patients based on different genotypes of IRS.1. Patients with mutated IRS.1 were not showing the same response as patients with intact IRS.1 gene. This finding provides data to support future PCOS clinical trials about Iraqi population, but also shows how genetics and polymorphism can play an important role in explaining how the response of PCOS patients might differ according to a specific type of polymorphism.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-04-05T11:32:33Z
No. of bitstreams: 1
Raya_Al_Shaikhly_Thesis_Redacted.pdf: 1441094 bytes, checksum: 7c10043d1a32d509c66d5adb82bb3580 (MD5)
Made available in DSpace on 2022-04-05T11:32:33Z (GMT). No. of bitstreams: 1
Raya_Al_Shaikhly_Thesis_Redacted.pdf: 1441094 bytes, checksum: 7c10043d1a32d509c66d5adb82bb3580 (MD5)
Previous issue date: 2021-01-01
1 online resource (xi, 53 leaves): col. ill.
Includes bibliographical references (leaf 43-53)
en
Metformin -- Therapeutic use
Polycystic ovary syndrome -- Treatment
Insulin resistance
Insulin -- Receptors
Women -- Health and hygiene -- Iraq
Lebanese American University -- Dissertations Corporate
Dissertations, Academic
The Effect of Genetic Polymorphism on Therapeutic Response of Metformin in Women with Polycystic Ovarian Syndrome in Iraqi Population
Thesis
Fall
Doctor of Pharmacy
SOP
200903055
Milane, Aline
Kanbar, Roy
Pharmaceutical Sciences
Mroueh, Mohamad
raya.al-shaikhly@lau.edu
Lebanese American University
Polycystic ovarian syndrome (PCOS)
metformin
polymorphism
the insulin receptor substrate-1(IRS.1)
insulin resistance (IR)
Iraqi population
Lebanese American University
ORIGINAL
Raya_Al_Shaikhly_Thesis_Redacted.pdf
Raya_Al_Shaikhly_Thesis_Redacted.pdf
application/pdf
1441094
https://laur.lau.edu.lb:8443/bitstream/10725/13444/1/Raya_Al_Shaikhly_Thesis_Redacted.pdf
7c10043d1a32d509c66d5adb82bb3580
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13444/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/13444
oai:laur.lau.edu.lb:10725/13444
2022-07-14 10:48:12.969
DSpace at LAU
joseph.sayah@lau.edu.lb
TEVCQU5FU0UgQU1FUklDQU4gVU5JVkVSU0lUWSBOT04tRVhDTFVTSVZFIERJU1RSSUJVVElPTiBMSUNFTlNFIA0KDQpCeSBzaWduaW5nIGFuZCBzdWJtaXR0aW5nIHRoaXMgbGljZW5zZSwgeW91ICh0aGUgYXV0aG9yKHMpIG9yIGNvcHlyaWdodCBvd25lcikgZ3JhbnRzIHRoZSBMZWJhbmVzZSBBbWVyaWNhbiBVbml2ZXJzaXR5IChMQVUpIHRoZSBub24tZXhjbHVzaXZlIHJpZ2h0IHRvIHJlcHJvZHVjZSwgdHJhbnNsYXRlIChhcyBkZWZpbmVkIGJlbG93KSwgYW5kL29yIGRpc3RyaWJ1dGUgeW91ciBzdWJtaXNzaW9uIChpbmNsdWRpbmcgdGhlIGFic3RyYWN0KSB3b3JsZHdpZGUgaW4gcHJpbnQgYW5kIGVsZWN0cm9uaWMgZm9ybWF0cyBhbmQgaW4gYW55IG1lZGl1bSwgaW5jbHVkaW5nIGJ1dCBub3QgbGltaXRlZCB0byBhdWRpbyBvciB2aWRlby4gWW91IGFncmVlIHRoYXQgTEFVIG1heSwgd2l0aG91dCBjaGFuZ2luZyB0aGUgY29udGVudCwgdHJhbnNsYXRlIHRoZSBzdWJtaXNzaW9uIHRvIGFueSBtZWRpdW0gb3IgZm9ybWF0IGZvciB0aGUgcHVycG9zZSBvZiBwcmVzZXJ2YXRpb24uIFlvdSBhbHNvIGFncmVlIHRoYXQgTEFVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yIHB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrdXAgYW5kIHByZXNlcnZhdGlvbi4gWW91IHJlcHJlc2VudCB0aGF0IHRoZSBzdWJtaXNzaW9uIGlzIHlvdXIgb3JpZ2luYWwgd29yaywgYW5kIHRoYXQgeW91IGhhdmUgdGhlIHJpZ2h0IHRvIGdyYW50IHRoZSByaWdodHMgY29udGFpbmVkIGluIHRoaXMgbGljZW5zZS4gWW91IGFsc28gcmVwcmVzZW50IHRoYXQgeW91ciBzdWJtaXNzaW9uIGRvZXMgbm90LCB0byB0aGUgYmVzdCBvZiB5b3VyIGtub3dsZWRnZSwgaW5mcmluZ2UgdXBvbiBhbnlvbmXigJlzIGNvcHlyaWdodC4gSWYgdGhlIHN1Ym1pc3Npb24gY29udGFpbnMgbWF0ZXJpYWwgZm9yIHdoaWNoIHlvdSBkbyBub3QgaG9sZCBjb3B5cmlnaHQsIHlvdSByZXByZXNlbnQgdGhhdCB5b3UgaGF2ZSBvYnRhaW5lZCB0aGUgdW5yZXN0cmljdGVkIHBlcm1pc3Npb24gb2YgdGhlIGNvcHlyaWdodCBvd25lciB0byBncmFudCBMQVUgdGhlIHJpZ2h0cyByZXF1aXJlZCBieSB0aGlzIGxpY2Vuc2UsIGFuZCB0aGF0IHN1Y2ggdGhpcmQtcGFydHkgb3duZWQgbWF0ZXJpYWwgaXMgY2xlYXJseSBpZGVudGlmaWVkIGFuZCBhY2tub3dsZWRnZWQgd2l0aGluIHRoZSB0ZXh0IG9yIGNvbnRlbnQgb2YgdGhlIHN1Ym1pc3Npb24uIElGIFRIRSBTVUJNSVNTSU9OIElTIEJBU0VEIFVQT04gV09SSyBUSEFUIEhBUyBCRUVOIFNQT05TT1JFRCBPUiBTVVBQT1JURUQgQlkgQU4gQUdFTkNZIE9SIE9SR0FOSVpBVElPTiBPVEhFUiBUSEFOIExBVSwgWU9VIFJFUFJFU0VOVCBUSEFUIFlPVSBIQVZFIEZVTEZJTExFRCBBTlkgUklHSFQgT0YgUkVWSUVXIE9SIE9USEVSIE9CTElHQVRJT05TIFJFUVVJUkVEIEJZIFNVQ0ggQ09OVFJBQ1QgT1IgQUdSRUVNRU5ULiBMQVUgd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZSBzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMgbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLg==
oai:laur.lau.edu.lb:10725/134452022-07-14T07:44:35Zcom_10725_2058col_10725_2074
El-Ratel, Rayan
2022-04-05T11:32:50Z
2022-04-05T11:32:50Z
2020
2020-12-25
http://hdl.handle.net/10725/13445
https://doi.org/10.26756/th.2022.336
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
The use of corticosteroids in the management of sepsis has been quite controversial. This thesis was motivated by a pursuit to gain a better understanding about the safety and efficacy of using corticosteroids in sepsis. In order to achieve our objective, this thesis will capitalize on an intervention that has been previously implemented in a private hospital in Lebanon. The intervention entailed adding corticosteroids to the management protocol of a group of septic patients. Also to better understand the importance of this intervention, this thesis will specifically compare clinical outcomes of the group of patients who received the intervention (which took place between February 2018 and April 2019), to another group of septic patients admitted prior to the implementation of the intervention (patients admitted between January 2016 and February 2018).
This study is in no way an interventional study, it will build on and analyze a previously conducted intervention in a retrospective manner.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-04-05T11:32:50Z
No. of bitstreams: 1
Rayan_F_El_Ratel_Thesis_Redacted.pdf: 2447852 bytes, checksum: de836de80b7b9f63bb3c172e610c4873 (MD5)
Made available in DSpace on 2022-04-05T11:32:50Z (GMT). No. of bitstreams: 1
Rayan_F_El_Ratel_Thesis_Redacted.pdf: 2447852 bytes, checksum: de836de80b7b9f63bb3c172e610c4873 (MD5)
Previous issue date: 2020-12-25
1 online resource (xiii, 82 leaves): ill. (some col.)
Includes bibliographical references (leaf 60-69)
en
Septic shock -- Treatment -- Lebanon
Septicemia -- Treatment -- Lebanon
Corticosterone -- Physiological effect
Lebanese American University -- Dissertations
Dissertations, Academic
The role of corticosteroids in the early management of sepsis in the Lebanese population
Thesis
Fall
MS in Pharmaceutical Development And Management
SOP
201206088
Tabbouche, Omar
Chamoun, Nibal
Pharmaceutical Sciences
Dimassi, Hani
rayan.elratel@lau.edu
Lebanese American University
Sepsis
septic shock
Intensive care unit
corticosteroids
Lebanese American University
ORIGINAL
Rayan_F_El_Ratel_Thesis_Redacted.pdf
Rayan_F_El_Ratel_Thesis_Redacted.pdf
application/pdf
2447852
https://laur.lau.edu.lb:8443/bitstream/10725/13445/1/Rayan_F_El_Ratel_Thesis_Redacted.pdf
de836de80b7b9f63bb3c172e610c4873
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13445/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/13445
oai:laur.lau.edu.lb:10725/13445
2022-07-14 10:44:35.999
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/134472022-07-14T06:54:33Zcom_10725_2058col_10725_2074
El Soussi, Sarra
2022-04-05T11:33:29Z
2022-04-05T11:33:29Z
2020
2020-11-19
http://hdl.handle.net/10725/13447
https://doi.org/10.26756/th.2022.334
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
The small molecule inducers of TRAIL ONC201/TIC10 and its analog ONC206 exhibit anti-tumor activity by inhibiting AKT/ERK phosphorylation and causing early activation of the integrated stress response. They are reported to inhibit the DRD2 receptors and activate mitochondrial ClpP leading to apoptosis and reduced proliferation in various tumors. Neuroblastoma is the most common extra-cranial nervous system tumor in children that presents with a spectrum of clinical prognostic measures ranging from benign growths that regress spontaneously to highly malignant, treatment evasive tumors affiliated with high mortality rates. MYCN amplification renders this tumor highly malignant and recurrence prone. In our current study we report for the first time, a novel inhibition of EGF-induced L1CAM and PDGFRβ phosphorylation with either ONC201 or ONC206 treatment in human MYCN-amplified neuroblastoma IMR-32 and non-MYCN amplified SK-N-SH cell lines. Drug treatment in these cells significantly reduced cellular proliferation, viability, migration and increased apoptosis. Tumorsphere formation potential was further significantly reduced with either drug treatment in both cell lines with ONC206 exhibiting much higher potency. MYCN expression was significantly abrogated in the IMR-32 cell line with either drug treatment. The protein expression of Sox-2, Oct-4, FABP5 and HMGA1 was significantly reduced whereas cleaved PARP1 and caspase-3 and p-H2AX was increased 48 h after drug treatment in the MYCN-amplified IMR-32 cell line. We are the first to report this novel differential protein expression after ONC201 or ONC206 treatment in these cells. Our findings demonstrate an important multi-target effect of imipridones that may yield added therapeutic benefits in treating this devastating cancer.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-04-05T11:33:29Z
No. of bitstreams: 1
Sarra_El_Soussi_Thesis_Redacted.pdf: 2622669 bytes, checksum: 561657987ec5f8921f57baa6b8241a67 (MD5)
Made available in DSpace on 2022-04-05T11:33:29Z (GMT). No. of bitstreams: 1
Sarra_El_Soussi_Thesis_Redacted.pdf: 2622669 bytes, checksum: 561657987ec5f8921f57baa6b8241a67 (MD5)
Previous issue date: 2020-11-19
1 online resource (xi, 83 leaves): col. ill.
Bibliography: leaf 55-83.
en
Neuroblastoma -- Molecular aspects
Neuroblastoma -- Treatment
Cell proliferation -- Drug effects
Lebanese American University -- Dissertations
Dissertations, Academic
Investigating the Therapeutic Effects of Small Molecule Imipridones In Pediatric Neuroblastoma
Thesis
Fall
MS in Pharmaceutical Development And Management
SOP
201806724
Abdallah, Jad
Khazen, George
Pharmaceutical Sciences
Abou-Antoun, Tamara
sarra.elsoussi@lau.edu
Lebanese American University
ONC201/206
neuroblastoma
PDGFRβ
L1CAM
HMGA1
FABP5
Sox-2
Oct-4
MYCN
y-H2AX
Lebanese American University
ORIGINAL
Sarra_El_Soussi_Thesis_Redacted.pdf
Sarra_El_Soussi_Thesis_Redacted.pdf
application/pdf
2622669
https://laur.lau.edu.lb:8443/bitstream/10725/13447/1/Sarra_El_Soussi_Thesis_Redacted.pdf
561657987ec5f8921f57baa6b8241a67
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13447/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/13447
oai:laur.lau.edu.lb:10725/13447
2022-07-14 09:54:33.662
DSpace at LAU
joseph.sayah@lau.edu.lb
TEVCQU5FU0UgQU1FUklDQU4gVU5JVkVSU0lUWSBOT04tRVhDTFVTSVZFIERJU1RSSUJVVElPTiBMSUNFTlNFIA0KDQpCeSBzaWduaW5nIGFuZCBzdWJtaXR0aW5nIHRoaXMgbGljZW5zZSwgeW91ICh0aGUgYXV0aG9yKHMpIG9yIGNvcHlyaWdodCBvd25lcikgZ3JhbnRzIHRoZSBMZWJhbmVzZSBBbWVyaWNhbiBVbml2ZXJzaXR5IChMQVUpIHRoZSBub24tZXhjbHVzaXZlIHJpZ2h0IHRvIHJlcHJvZHVjZSwgdHJhbnNsYXRlIChhcyBkZWZpbmVkIGJlbG93KSwgYW5kL29yIGRpc3RyaWJ1dGUgeW91ciBzdWJtaXNzaW9uIChpbmNsdWRpbmcgdGhlIGFic3RyYWN0KSB3b3JsZHdpZGUgaW4gcHJpbnQgYW5kIGVsZWN0cm9uaWMgZm9ybWF0cyBhbmQgaW4gYW55IG1lZGl1bSwgaW5jbHVkaW5nIGJ1dCBub3QgbGltaXRlZCB0byBhdWRpbyBvciB2aWRlby4gWW91IGFncmVlIHRoYXQgTEFVIG1heSwgd2l0aG91dCBjaGFuZ2luZyB0aGUgY29udGVudCwgdHJhbnNsYXRlIHRoZSBzdWJtaXNzaW9uIHRvIGFueSBtZWRpdW0gb3IgZm9ybWF0IGZvciB0aGUgcHVycG9zZSBvZiBwcmVzZXJ2YXRpb24uIFlvdSBhbHNvIGFncmVlIHRoYXQgTEFVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yIHB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrdXAgYW5kIHByZXNlcnZhdGlvbi4gWW91IHJlcHJlc2VudCB0aGF0IHRoZSBzdWJtaXNzaW9uIGlzIHlvdXIgb3JpZ2luYWwgd29yaywgYW5kIHRoYXQgeW91IGhhdmUgdGhlIHJpZ2h0IHRvIGdyYW50IHRoZSByaWdodHMgY29udGFpbmVkIGluIHRoaXMgbGljZW5zZS4gWW91IGFsc28gcmVwcmVzZW50IHRoYXQgeW91ciBzdWJtaXNzaW9uIGRvZXMgbm90LCB0byB0aGUgYmVzdCBvZiB5b3VyIGtub3dsZWRnZSwgaW5mcmluZ2UgdXBvbiBhbnlvbmXigJlzIGNvcHlyaWdodC4gSWYgdGhlIHN1Ym1pc3Npb24gY29udGFpbnMgbWF0ZXJpYWwgZm9yIHdoaWNoIHlvdSBkbyBub3QgaG9sZCBjb3B5cmlnaHQsIHlvdSByZXByZXNlbnQgdGhhdCB5b3UgaGF2ZSBvYnRhaW5lZCB0aGUgdW5yZXN0cmljdGVkIHBlcm1pc3Npb24gb2YgdGhlIGNvcHlyaWdodCBvd25lciB0byBncmFudCBMQVUgdGhlIHJpZ2h0cyByZXF1aXJlZCBieSB0aGlzIGxpY2Vuc2UsIGFuZCB0aGF0IHN1Y2ggdGhpcmQtcGFydHkgb3duZWQgbWF0ZXJpYWwgaXMgY2xlYXJseSBpZGVudGlmaWVkIGFuZCBhY2tub3dsZWRnZWQgd2l0aGluIHRoZSB0ZXh0IG9yIGNvbnRlbnQgb2YgdGhlIHN1Ym1pc3Npb24uIElGIFRIRSBTVUJNSVNTSU9OIElTIEJBU0VEIFVQT04gV09SSyBUSEFUIEhBUyBCRUVOIFNQT05TT1JFRCBPUiBTVVBQT1JURUQgQlkgQU4gQUdFTkNZIE9SIE9SR0FOSVpBVElPTiBPVEhFUiBUSEFOIExBVSwgWU9VIFJFUFJFU0VOVCBUSEFUIFlPVSBIQVZFIEZVTEZJTExFRCBBTlkgUklHSFQgT0YgUkVWSUVXIE9SIE9USEVSIE9CTElHQVRJT05TIFJFUVVJUkVEIEJZIFNVQ0ggQ09OVFJBQ1QgT1IgQUdSRUVNRU5ULiBMQVUgd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZSBzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMgbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLg==
oai:laur.lau.edu.lb:10725/134532022-07-14T05:50:48Zcom_10725_2058col_10725_2074
Rammal, Hassan A
2022-04-05T12:49:10Z
2022-04-05T12:49:10Z
2020
2020-06-07
http://hdl.handle.net/10725/13453
https://doi.org/10.26756/th.2022.329
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Controlled-Release drug delivery using microspheres depends on drug-encapsulation formulation, processing conditions, and excipient physical properties. Several parameters affect the microspheres’ formation and properties, including Physical, Chemical, and dissolution profile. This thesis aims to gain a better understanding of the number and type of parameters which affect the properties of Ethyl-Cellulose-Theophylline microspheres, and also attempts to explain the reason why said parameter affects said property in a certain specific way. In order to fully explore by
which means drug-encapsulated microspheres are affected, this thesis looked at eight different parameters which were suspected to trigger changes in the properties of microspheres. The final aim of this thesis was to develop the most effective, efficient, and environmentally friendly method to form microspheres possessing the most beneficial properties for controlled release drug delivery
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-04-05T12:49:10Z
No. of bitstreams: 1
Hassan_A_Rammal_Thesis_Redacted.pdf: 2446948 bytes, checksum: b56ba2ace4edbe6db7bf0ad222e16098 (MD5)
Made available in DSpace on 2022-04-05T12:49:10Z (GMT). No. of bitstreams: 1
Hassan_A_Rammal_Thesis_Redacted.pdf: 2446948 bytes, checksum: b56ba2ace4edbe6db7bf0ad222e16098 (MD5)
Previous issue date: 2020-06-07
1 online resource (xiii, 94 leaves) ; ill. (some col.)
Includes bibliographical references (leaf 87-94)
en
Microspheres (Pharmacy)
Drug delivery systems
Microencapsulation
Ethylcellulose
Lebanese American University -- Dissertations
Dissertations, Academic
The Effect of Formulation Parameters on the Physical Properties and In-Vitro Dissolution Profile of Ethyl Cellulose-Theophylline Microspheres Using the Emulsion-Solvent Evaporation Process
Nonionic Surfactant Structure and Concentration, Temperature and Solvent
Thesis
Spring
MS in Pharmaceutical Development And Management
SOP
201806588
Mroueh, Mohammad
Milane, Aline
Pharmaceutical Sciences
Capomacchia, Anthony
hassan.rammal02@lau.edu
Lebanese American University
Microspheres
Drug-Encapsulation
Method Optimization
Ethyl- Cellulose
Theophylline
Lebanese American University
ORIGINAL
Hassan_A_Rammal_Thesis_Redacted.pdf
Hassan_A_Rammal_Thesis_Redacted.pdf
application/pdf
2446948
https://laur.lau.edu.lb:8443/bitstream/10725/13453/1/Hassan_A_Rammal_Thesis_Redacted.pdf
b56ba2ace4edbe6db7bf0ad222e16098
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13453/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/13453
oai:laur.lau.edu.lb:10725/13453
2022-07-14 08:50:48.902
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/136622023-05-10T09:29:48Zcom_10725_2058col_10725_2074
Saliba, Jane
2022-06-15T05:51:15Z
2022-06-15T05:51:15Z
2021
2021-05-31
http://hdl.handle.net/10725/13662
https://doi.org/10.26756/th.2022.250
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Cannabis sativa L. is one of the oldest plants used in traditional medicine. Lebanese cannabis is recognized around the world for its quality and recreational use; however, little is known about its medicinal importance. Cannabis is a distinctive plant containing a variety of compounds most notably cannabinoids and terpenoids. Cannabis oil extract (COE) has been shown to possess anti-inflammatory and anticancer activities, which could be attributed to the interaction between terpenes and cannabinoids as “entourage effect”. In this study, we look at the anti-tumorigenic effects of Lebanese COE on non-small cell lung cancer cell line (NSCLC) A549 and the triple negative breast cancer cell line (MDA-MB-231). GC-MS analysis of COE revealed CBD dominance (59.1%) followed by THC (20.2%). Cell viability was evaluated using MTS cell proliferation assay and COE demonstrated more selectivity against MDA-MB-231 (IC50 =26.7 μg/mL) and A549 (IC50 =30.2 μg/mL), compared to rat stem cells (IC50 =42.31 μg/mL). COE caused more significant cell migration inhibition in A549 cells than MDA-MB-231 cells. Western blot analysis showed significant increase in MAPK/ERK pathway and the autophagic marker LC3B. Cell cycle analysis by flow cytometry and western blot assay revealed a minor involvement of apoptosis in cell death. In conclusion, the results confirmed that COE has dose/time dependent effect and is effective in inhibiting cancer cell migration These results necessitate further studies to better understand the complex cell-death mechanisms of COE and provide supportive evidence for its use in cancer treatment.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-06-15T05:51:15Z
No. of bitstreams: 1
Jane_Abdallah_Saliba_Thesis.pdf: 2549366 bytes, checksum: 848ec7f447a368ed5ae9d1b8bb457521 (MD5)
Made available in DSpace on 2022-06-15T05:51:15Z (GMT). No. of bitstreams: 1
Jane_Abdallah_Saliba_Thesis.pdf: 2549366 bytes, checksum: 848ec7f447a368ed5ae9d1b8bb457521 (MD5)
Previous issue date: 2021-05-31
1 online resource (xvii, 58 leaves): ill. (some col.)
Includes bibliographical references (leaf 52-58)
en
Lungs -- Cancer -- Molecular aspects
Breast -- Cancer -- Molecular aspects
Cannabis -- Therapeutic use
Anti-cancer Evaluation of Lebanese Cannabis Oil Extract on Lung and Breast Cancer Cells
Thesis
Spring
MS in Pharmaceutical Development And Management
SOP
201301046
Daher, Costantine
Abou Antoun, Tamara
Pharmaceutical Sciences
Mroueh, Mohamad
Shebaby, Wassim
jane.saliba@lau.edu.lb
Lebanese American University
Entourage effect
Breast cancer (MDA-MB-231)
Lung cancer (A549)
Cannabis, Cannabinoids
Lebanese American University
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13662/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
ORIGINAL
Jane_Abdallah_Saliba_Thesis_Redacted.pdf
Jane_Abdallah_Saliba_Thesis_Redacted.pdf
application/pdf
3010252
https://laur.lau.edu.lb:8443/bitstream/10725/13662/3/Jane_Abdallah_Saliba_Thesis_Redacted.pdf
c8cec823d3db25e87eda7e6fc39fa096
MD5
3
10725/13662
oai:laur.lau.edu.lb:10725/13662
2023-05-10 12:29:48.442
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/137382023-05-10T09:24:34Zcom_10725_2058col_10725_2074
Al Sayed, Dania
2022-06-22T08:27:41Z
2022-06-22T08:27:41Z
2021
2021-12-14
http://hdl.handle.net/10725/13738
https://doi.org/10.26756/th.2023.573
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Lebanese cannabis is well-known for its high quality and recreational value; yet little is known regarding its medical use. Hyperthyroidism affects approximately 1%-2% of the world population. Limited literature is available on cannabis use on thyroid dysfunction. The present study aims to explore the antithyroid potential of Lebanese cannabis oil extract (COE) use in mice. Male BALB/c mice weighing between 31 and 35 grams were distributed into five groups of 14 mice each; group I served as control and was given a mixture of Ethanol: Cremophor: PBS (1:1:18) administered intra peritoneally (i.p.) for 35 days. To induce hyperthyroidism, group II was given levo- thyroxine (10μg) orally for 35 days; groups III, IV, and V were given levo- thyroxine (10μg) over 14 days and then treated with PTU (0.2mg/kg PO), COE (10mg/kg i.p.), and COE (20mg/kg i.p.), respectively over 21 days. The effect of COE on hyperthyroidism was assessed by measuring FT3, FT4 and TSH levels in mice blood. Mice liver and thyroid morphology was examined, as well. Results show that COE and PTU where equally effective in controlling FT3 levels in mice (P-value <0.001), but PTU was more potent than COE dose I and dose II in abating FT4 levels. Regarding thyroid and liver morphology, the group treated with COE dose II (group V) showed the lowest thyroid weight as compared to other treated groups (III, IV). To note, there was no observed difference in the liver morphology in any of the treated and control groups. In conclusion, the results assured that COE has dose/time dependent effect in lowering FT3 and FT4 thyroid hormones. Further studies are required to acknowledge the mechanism of action of COE antithyroid effect.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-06-22T08:27:41Z
No. of bitstreams: 1
Dania_Abida_Nayef_Al_Sayed_Thesis_Redacted.pdf: 1496832 bytes, checksum: 32489fb0609098f3e68cc8b1007d2a40 (MD5)
Made available in DSpace on 2022-06-22T08:27:41Z (GMT). No. of bitstreams: 1
Dania_Abida_Nayef_Al_Sayed_Thesis_Redacted.pdf: 1496832 bytes, checksum: 32489fb0609098f3e68cc8b1007d2a40 (MD5)
Previous issue date: 2021-12-14
1 online resource (xii, 76 leaves): ill. (some col.)
Includes bibliographical references (leaf 68-74)
en
Cannabis -- Therapeutic use
Thyroid antagonists
Thyroid antagonists -- Physiological effect
Lebanese American University -- Dissertations
Dissertations, Academic
Evaluation Of Anti Thyroid Activity of Cannabis Sativa Oil Extract Against Levothyroxine Induced Hyperthyroidism in Mice
Thesis
Fall
MS in Pharmaceutical Development And Management
SOP
201906032
Mroueh, Mohamad
Faour, Wissam
Pharmaceutical Sciences
Saab, Yolande
Shebaby, Wassim
daniaabida.alsayed@lau.edu
Lebanese American University
Thyroid Gland
TSH
FT4
FT3
CB1 Receptor
CB2 Receptor
Entourage Effect
Cannabis Sativa
Cannabinoids
Levo-thyroxine Induced Hyperthyroidism
PTU Standard Drug
Lebanese American University
ORIGINAL
Dania_Abida_Nayef_Al_Sayed_Thesis_Redacted.pdf
Dania_Abida_Nayef_Al_Sayed_Thesis_Redacted.pdf
application/pdf
1496832
https://laur.lau.edu.lb:8443/bitstream/10725/13738/1/Dania_Abida_Nayef_Al_Sayed_Thesis_Redacted.pdf
32489fb0609098f3e68cc8b1007d2a40
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13738/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/13738
oai:laur.lau.edu.lb:10725/13738
2023-05-10 12:24:34.259
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/137472022-06-30T05:44:45Zcom_10725_2058col_10725_2074
Zgheib, Rebecca
2022-06-22T09:29:00Z
2022-06-22T09:29:00Z
2022
2022-01-14
http://hdl.handle.net/10725/13747
https://doi.org/10.26756/th.2022.179
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Since the outbreak of Coronavirus Disease 2019 (CoVID-19), the World Health Organization has suggested that alcohol-based hand sanitizers should be used in the absence of soap and water to prevent the spread of SARS-CoV2.
This study aimed to assess the efficacy and toxicity of hand sanitizers produced and/or distributed on the Lebanese market. The study included 31 different brands of hand sanitizers that were analyzed using headspace gas chromatography- mass spectrometry to detect impurities and alcohol content. The impurities were identified based on a Mass Spectrometry database. Regression analysis was used to determine ethanol percentage.
Accordingly, a toxicological review was conducted to assess the various risks associated with the usage of hand sanitizers.
Detected impurities mainly included but not limited to ethyl acetate, benzene, acetone, and acetal.
Among the ethanol-containing hand sanitizers, 71% contained less than 60% v/v alcohol not complying with the CDC and WHO recommendations which state that ethanol concentration should be at least 60%. Isobutanol and other non-recommended alcohols (methanol and 1-propanol) were also detected as contaminations.
Consumers should be aware that some hand sanitizers available on the Lebanese market are ineffective and include residues of harmful substances.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-06-22T09:29:00Z
No. of bitstreams: 1
Rebecca_Hanna_Zgheib_Thesis_Redacted.pdf: 1599339 bytes, checksum: d5aea3601ab30bf54ed623a8f3dced9b (MD5)
Made available in DSpace on 2022-06-22T09:29:00Z (GMT). No. of bitstreams: 1
Rebecca_Hanna_Zgheib_Thesis_Redacted.pdf: 1599339 bytes, checksum: d5aea3601ab30bf54ed623a8f3dced9b (MD5)
Previous issue date: 2022-01-14
1 online resource (xiii, 59 leaves): ill. (some col.)
Includes bibliographical references (leaf 47-54).
en
Hand -- Care and hygiene
Hand washing
Antiseptics
COVID-19 (Disease) -- Prevention
Lebanese American University -- Dissertations
Dissertations, Academic
Efficacy and Toxicity of Hand Sanitizers
Detection of Impurities and Evaluation of Alcohol Content
Thesis
Fall
MS in Pharmaceutical Development And Management
SOP
201402308
Knoayzer, Rony
Mehanna, Rony
Pharmaceutical Sciences
Saab, Yolande
rebecca.zgheib@lau.edu
Lebanese American University
Hand Sanitizer
COVID-19
Impurities
Headspace Gas Chromatography
Alcohol Content
Lebanese American University
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13747/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
ORIGINAL
Rebecca_Hanna_Zgheib_Thesis_Redacted.pdf
Rebecca_Hanna_Zgheib_Thesis_Redacted.pdf
application/pdf
1599339
https://laur.lau.edu.lb:8443/bitstream/10725/13747/1/Rebecca_Hanna_Zgheib_Thesis_Redacted.pdf
d5aea3601ab30bf54ed623a8f3dced9b
MD5
1
10725/13747
oai:laur.lau.edu.lb:10725/13747
2022-06-30 08:44:45.395
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/137482022-06-22T09:31:53Zcom_10725_2058col_10725_2074
Rahme, Rita
2022-06-22T09:31:53Z
2022-06-22T09:31:53Z
2022
2022-01-27
http://hdl.handle.net/10725/13748
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Introduction: The presence of impurities in pharmaceutical formulations has been a concern worldwide. Acetaminophen is a commonly used drug for its analgesic and antipyretic properties. We report here a novel method for the impurity profiling of intravenous acetaminophen formulations by head space gas chromatography. In addition, impurity profiling of oral acetaminophen tablets and capsules available on the Lebanese market and manufactured in Lebanon was not reported, as well.
Objective: The purpose of this study is to detect impurities present in intravenous and oral samples of acetaminophen on the Lebanese market and analyze the risks that these impurities pose to human health.
Methods: static headspace gas chromatography- mass spectrometry was utilized as one of the most suitable methods to detect organic volatile impurities. Samples for intravenous use where first lyophilized prior to analysis. A total of 25 samples were analyzed: 9 and 16 for intravenous and oral use, respectively. Toxicological review was performed on the detected impurities and the different risks associated were analyzed.
Results: of the 9 intravenous samples analyzed, 6 contained impurities. As for the oral samples, 9 out of 16 samples contained impurities. A total of 14 different impurities were detected: acetaldehyde, cyclomethicone 5, cyclomethicone 6, dibutyl phthalate, diethyl phthalate, diacetamate, ethanol, ethyl stearate, formic acid, glycidol, methyl carbamate, methyl hydrazine, methyl stearate, and triethylamine. Several of the detected impurities are highly nephrotoxic, hepatotoxic, neurotoxic, carcinogenic, and/or teratogenic.
Conclusion: In view of the toxicity of the detected impurities and the negative impact they carry on the quality of the formulation as well as on human health, it is of utmost importance for the concerned pharmaceutical industries to take appropriate measures to control the source of these impurities and abide by the guidelines set by the regulatory authorities all around the world. Regulatory authorities should also take the necessary measures to preserve the safety of treated patients.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-06-22T09:31:53Z
No. of bitstreams: 1
Rita_Rahme_Thesis_Redacted.pdf: 1531101 bytes, checksum: 5064a32c4412a2708edeefae98370632 (MD5)
Made available in DSpace on 2022-06-22T09:31:53Z (GMT). No. of bitstreams: 1
Rita_Rahme_Thesis_Redacted.pdf: 1531101 bytes, checksum: 5064a32c4412a2708edeefae98370632 (MD5)
Previous issue date: 2022-01-27
1 online resource (xiv, 53 leaves): ill. (some col.)
Includes bibliographical references (leaf 43-50).
en
Acetaminophen -- Toxicology
Environmental chemistry
Chromatographic analysis
Lebanese American University -- Dissertations
Dissertations, Academic
Detection of Impurities in Acetaminophen Intravenous and Oral Formulations Available on the Lebanese Market
Thesis
Fall
MS in Pharmaceutical Development And Management
SOP
201400934
Khnayzer, Rony
Mehanna, Stephanie
Pharmaceutical Sciences
Saab, Yolande
rita.rahme@lau.edu
Lebanese American University
Impurities
Volatile Organic Impurities
Impurity Profiling
Chromatography
Headspace GC-MS
Acetaminophen
Toxicology
Lebanese American University
ORIGINAL
Rita_Rahme_Thesis_Redacted.pdf
Rita_Rahme_Thesis_Redacted.pdf
application/pdf
1531101
https://laur.lau.edu.lb:8443/bitstream/10725/13748/1/Rita_Rahme_Thesis_Redacted.pdf
5064a32c4412a2708edeefae98370632
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13748/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/13748
oai:laur.lau.edu.lb:10725/13748
2022-06-22 12:31:53.108
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/136372022-07-07T06:22:53Zcom_10725_2058col_10725_2074
El Hajj, Antonio
2022-06-13T08:57:28Z
2022-06-13T08:57:28Z
2021
2021-08-02
http://hdl.handle.net/10725/13637
https://doi.org/10.26756/th.2022.270
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Objective: Thin film (TF) is an oral mucosal drug delivery system that disintegrates and dissolves the drug rapidly when placed on any oral mucosal tissue. This work aimed to develop and characterize TF containing carbinoxamine maleate (CM) for the symptomatic treatment of seasonal and perennial allergies and other allergic conditions.
Methods: Three optimized batches were developed by solvent-casting method with different ratios of blends of hydroxypropyl methylcellulose (HPMC) E50LV and polyvinylpyrrolidone (PVP) K12 or K85-95 as mucoadhesive film-forming polymers. The produced TFs were subjected to physicochemical and mechanical characterization.
Results: The weight and thickness of TF were in the range of 40.47 mg ± 0.49 to 65.70 mg ± 1.51 and 50.80 μm ± 1.11 to 95.20 μm ± 2.50, respectively. The percent drug load was found to be within the acceptable limit for content uniformity. Within 15 minutes, the amount of CM released from thin films of Batch 3 was 81.04% ± 1.91 which was significantly slower than Batch 1 and Batch 2. The disintegration of TFs was achieved in less than 180 seconds. Results of mechanical testing revealed high values of Young’s modulus with no significant difference between batches. The incorporation of blends of HPMC E50 LV and PVP K85-95 at a ratio of 1:1 notably decreased tensile strength and elongation at break.
Conclusion: This work demonstrates the successful development of TF as an adequate delivery system for the administration of CM. The selection of the film-forming polymer type, grade, and ratio can impact the characteristics of the TF and modify the delivery of CM.
Keywords: Mucoadhesive Polymers, Thin Film, Drug Delivery, Carbinoxamine Maleate.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-06-13T08:57:28Z
No. of bitstreams: 1
Antonio_Charbel_El_Hajj_Thesis_Redacted.pdf: 2262181 bytes, checksum: b70b5d384bb0307e5af5810178590940 (MD5)
Made available in DSpace on 2022-06-13T08:57:28Z (GMT). No. of bitstreams: 1
Antonio_Charbel_El_Hajj_Thesis_Redacted.pdf: 2262181 bytes, checksum: b70b5d384bb0307e5af5810178590940 (MD5)
Previous issue date: 2021-08-02
1 online resource (xiii, 54 leaves) : col. ill.
Includes bibliographical references (leaf 47-53)
en
Thin films
Drug delivery systems
Polymeric drugs
Lebanese American University -- Dissertations
Dissertations, Academic
Development and Characterization of Mucoadhesive Thin Film as an Oral Mucosal Drug Delivery System of Carbinoxamine Maleate
Thesis
Summer
MS in Pharmaceutical Development And Management
SOP
201301103
Khalil, Claude
Mroueh, Mohammad
Pharmaceutical Sciences
Kanbar, Roy
Milane, Aline
antonio.elhajj@lau.edu
Lebanese American University
Mucoadhesive Polymers
Thin Film
Drug Delivery
Carbinoxamine Maleate
Lebanese American University
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13637/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
ORIGINAL
Antonio_Charbel_El_Hajj_Thesis_Redacted.pdf
Antonio_Charbel_El_Hajj_Thesis_Redacted.pdf
application/pdf
2262181
https://laur.lau.edu.lb:8443/bitstream/10725/13637/1/Antonio_Charbel_El_Hajj_Thesis_Redacted.pdf
b70b5d384bb0307e5af5810178590940
MD5
1
10725/13637
oai:laur.lau.edu.lb:10725/13637
2022-07-07 09:22:53.208
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/136492022-07-06T10:58:54Zcom_10725_2058col_10725_2074
Al Sayyed, Fatima
2022-06-14T06:34:18Z
2022-06-14T06:34:18Z
2021
2021-08-04
http://hdl.handle.net/10725/13649
https://doi.org/10.26756/th.2022.262
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Neuroblastoma is the most common malignant tumor of infancy and accounts for 10% of all childhood cancers. The high biological and clinical heterogeneity of this tumor leads to differences in clinical outcomes ranging from benign tumors that regress spontaneously to metastatic tumors that are ultimately fatal. Despite the recent advances, many children continue to suffer from refractory and relapsed diseases, and they often develop metastatic tumors resistant to standard treatments. Amplification of MYC-N proto-oncogene is highly associated with clinically aggressive disease, recurrence and treatment failure. The highly malignant rate in neuroblastoma is likely due to the continuous acquisition of genetic aberrations in undifferentiated neuroblastoma cancer stem cells (CSCs). CSCs play a crucial role in dysregulating different pathways that are involved in metastasis, invasion, angiogenic properties, uncontrolled proliferation, self-renewal capacities and therapeutic resistance. In this study, we investigate the efficacy of two small molecules Ruxolitinib, a JAK/STAT inhibitor, and CHIR-99021, a GSK-3 inhibitor, in targeting pediatric neuroblastoma stem cells by testing them on human MYC-N amplified, IMR-32, and non-MYC-N amplified, SK-N-SH, cell lines. Treating neuroblastoma cells with Ruxolitinib and CHIR-99021 resulted in significant reduction in cellular proliferation, viability, apoptosis and tumorsphere formation capacity in both IMR-32 and SK-N-SH cell lines. Western blot analysis showed significant decrease in stem cell markers SOX-2 and Oct-4, and tumorigenic protein HMGA1, whereas it showed significant increase in apoptotic markers cleaved PARP and cleaved caspase-3. In conclusion, our findings demonstrated that Ruxolitinib and CHIR-99021 could be promising therapies in targeting neuroblastoma CSCs, and that combining these two drugs may have added therapeutic effects in treating this malignant tumor. Further studies are warranted to elucidate the therapeutic mechanism through which these drugs act to target the various tumorigenic pathways.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-06-14T06:34:18Z
No. of bitstreams: 1
Fatima_Awad_Al_Sayyed_Thesis_Redacted.pdf: 7016409 bytes, checksum: bdf9d6d38d8ff51b6bdb8134a32e2a8f (MD5)
Made available in DSpace on 2022-06-14T06:34:18Z (GMT). No. of bitstreams: 1
Fatima_Awad_Al_Sayyed_Thesis_Redacted.pdf: 7016409 bytes, checksum: bdf9d6d38d8ff51b6bdb8134a32e2a8f (MD5)
Previous issue date: 2021-08-04
1 online resource (xii, 68 leaves) : ill. (some col.)
Bibliography: leaf 54-68.
en
Neuroblastoma -- Treatment
Stem cells -- Therapeutic use
Chemotherapy
Lebanese American University -- Dissertations
Dissertations, Academic
Investigating The Efficacy of Ruxolitinib and CHIR-99021 in Targeting Pediatric Neuroblastoma Stem Cells
Thesis
Summer
MS in Pharmaceutical Development And Management
SOP
201400426
Abou-Kheir, Wassim
Dimassi, Hani
Pharmaceutical Sciences
Abou-Antoun, Tamara
fatima.alsayyed@lau.edu
Lebanese American University
Neuroblastoma
Ruxolitinib
CHIR-99021
CSCs
MYC-N
JAK/STAT
GSK-3
SOX-2
Oct-4
HMGA1
Lebanese American University
ORIGINAL
Fatima_Awad_Al_Sayyed_Thesis_Redacted.pdf
Fatima_Awad_Al_Sayyed_Thesis_Redacted.pdf
application/pdf
7016409
https://laur.lau.edu.lb:8443/bitstream/10725/13649/1/Fatima_Awad_Al_Sayyed_Thesis_Redacted.pdf
bdf9d6d38d8ff51b6bdb8134a32e2a8f
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13649/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/13649
oai:laur.lau.edu.lb:10725/13649
2022-07-06 13:58:54.472
DSpace at LAU
joseph.sayah@lau.edu.lb
TEVCQU5FU0UgQU1FUklDQU4gVU5JVkVSU0lUWSBOT04tRVhDTFVTSVZFIERJU1RSSUJVVElPTiBMSUNFTlNFIA0KDQpCeSBzaWduaW5nIGFuZCBzdWJtaXR0aW5nIHRoaXMgbGljZW5zZSwgeW91ICh0aGUgYXV0aG9yKHMpIG9yIGNvcHlyaWdodCBvd25lcikgZ3JhbnRzIHRoZSBMZWJhbmVzZSBBbWVyaWNhbiBVbml2ZXJzaXR5IChMQVUpIHRoZSBub24tZXhjbHVzaXZlIHJpZ2h0IHRvIHJlcHJvZHVjZSwgdHJhbnNsYXRlIChhcyBkZWZpbmVkIGJlbG93KSwgYW5kL29yIGRpc3RyaWJ1dGUgeW91ciBzdWJtaXNzaW9uIChpbmNsdWRpbmcgdGhlIGFic3RyYWN0KSB3b3JsZHdpZGUgaW4gcHJpbnQgYW5kIGVsZWN0cm9uaWMgZm9ybWF0cyBhbmQgaW4gYW55IG1lZGl1bSwgaW5jbHVkaW5nIGJ1dCBub3QgbGltaXRlZCB0byBhdWRpbyBvciB2aWRlby4gWW91IGFncmVlIHRoYXQgTEFVIG1heSwgd2l0aG91dCBjaGFuZ2luZyB0aGUgY29udGVudCwgdHJhbnNsYXRlIHRoZSBzdWJtaXNzaW9uIHRvIGFueSBtZWRpdW0gb3IgZm9ybWF0IGZvciB0aGUgcHVycG9zZSBvZiBwcmVzZXJ2YXRpb24uIFlvdSBhbHNvIGFncmVlIHRoYXQgTEFVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yIHB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrdXAgYW5kIHByZXNlcnZhdGlvbi4gWW91IHJlcHJlc2VudCB0aGF0IHRoZSBzdWJtaXNzaW9uIGlzIHlvdXIgb3JpZ2luYWwgd29yaywgYW5kIHRoYXQgeW91IGhhdmUgdGhlIHJpZ2h0IHRvIGdyYW50IHRoZSByaWdodHMgY29udGFpbmVkIGluIHRoaXMgbGljZW5zZS4gWW91IGFsc28gcmVwcmVzZW50IHRoYXQgeW91ciBzdWJtaXNzaW9uIGRvZXMgbm90LCB0byB0aGUgYmVzdCBvZiB5b3VyIGtub3dsZWRnZSwgaW5mcmluZ2UgdXBvbiBhbnlvbmXigJlzIGNvcHlyaWdodC4gSWYgdGhlIHN1Ym1pc3Npb24gY29udGFpbnMgbWF0ZXJpYWwgZm9yIHdoaWNoIHlvdSBkbyBub3QgaG9sZCBjb3B5cmlnaHQsIHlvdSByZXByZXNlbnQgdGhhdCB5b3UgaGF2ZSBvYnRhaW5lZCB0aGUgdW5yZXN0cmljdGVkIHBlcm1pc3Npb24gb2YgdGhlIGNvcHlyaWdodCBvd25lciB0byBncmFudCBMQVUgdGhlIHJpZ2h0cyByZXF1aXJlZCBieSB0aGlzIGxpY2Vuc2UsIGFuZCB0aGF0IHN1Y2ggdGhpcmQtcGFydHkgb3duZWQgbWF0ZXJpYWwgaXMgY2xlYXJseSBpZGVudGlmaWVkIGFuZCBhY2tub3dsZWRnZWQgd2l0aGluIHRoZSB0ZXh0IG9yIGNvbnRlbnQgb2YgdGhlIHN1Ym1pc3Npb24uIElGIFRIRSBTVUJNSVNTSU9OIElTIEJBU0VEIFVQT04gV09SSyBUSEFUIEhBUyBCRUVOIFNQT05TT1JFRCBPUiBTVVBQT1JURUQgQlkgQU4gQUdFTkNZIE9SIE9SR0FOSVpBVElPTiBPVEhFUiBUSEFOIExBVSwgWU9VIFJFUFJFU0VOVCBUSEFUIFlPVSBIQVZFIEZVTEZJTExFRCBBTlkgUklHSFQgT0YgUkVWSUVXIE9SIE9USEVSIE9CTElHQVRJT05TIFJFUVVJUkVEIEJZIFNVQ0ggQ09OVFJBQ1QgT1IgQUdSRUVNRU5ULiBMQVUgd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZSBzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMgbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLg==
oai:laur.lau.edu.lb:10725/137262022-06-30T08:48:49Zcom_10725_2058col_10725_2074
Al Toufaily, Sahar
2022-06-17T06:47:39Z
2022-06-17T06:47:39Z
2021
2021-07-30
http://hdl.handle.net/10725/13726
https://doi.org/10.26756/th.2022.190
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Cisplatin is a standard antineoplastic drug that has been incorporated in many firstline chemotherapy regimens for the treatment of solid tumors such as, advanced ovarian, lung, head and neck, testicular and bladder. However, its use is associated with dose dependent nephrotoxicity, and ongoing attempts have been made to reduce the cisplatininduced
nephrotoxicity. The current study investigates the nephroprotective effects of two native Lebanese plants, Daucus carota and Cannabis sativa, in animal models. Previous studies in our laboratory showed that Daucus carota oil extract (DCOE) possesses antioxidant, anti-inflammatory, and anticancer properties. The major component of DCOE, β-2-himachalen-6-ol (HC), has been isolated and found to be a potential safe and potent chemotherapeutic agent. Additional recent studies showed that Cannabis sativa oil extract (COE) demonstrated potent anti-inflammatory effects.
DCOE (100 mg/kg body weight) and HC (25 and 50 mg/kg body weight) were administered daily to rats for 10 days, and a single dose of cisplatin (7.5 mg/kg body weight) was administered on day five. In another protocol, 2.5, 5, 10, and 20 mg/kg body weight of COE were given daily to mice for three days, and cisplatin (20 mg/kg body weight) was administered on day one. Serum creatinine and urea, proteinuria, and
inflammatory markers were measured. All used doses of COE showed significant decrease in serum urea; however, a significant decrease in serum creatinine was observed only at 20 mg/kg COE. On the other hand, treatment with HC (50 mg/kg) or DCOE (100mg/kg) demonstrated significant decrease in serum urea, but little or no effects was observed on serum creatinine. In addition, COE treatment caused a significant decrease in urinary albumin excretion. Furthermore, Western blot analysis with the antibodies against COX-2 was significantly lower in cisplatin-intoxicated mice with COE in comparison to mice treated with cisplatin alone. In conclusion, the current findings demonstrates that doses of HC (50 mg/kg) and DCOE (100 mg/kg), and all used doses of COE could be a promising approach to protect against cisplatin-induced nephrotoxicity, partially by
ameliorating inflammatory response.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-06-17T06:47:39Z
No. of bitstreams: 1
Sahar_Al_Toufaily_Thesis_Redacted.pdf: 2160472 bytes, checksum: 08c9c9f42083135f46f83b5648121bef (MD5)
Made available in DSpace on 2022-06-17T06:47:39Z (GMT). No. of bitstreams: 1
Sahar_Al_Toufaily_Thesis_Redacted.pdf: 2160472 bytes, checksum: 08c9c9f42083135f46f83b5648121bef (MD5)
Previous issue date: 2021-07-30
1 online resource (xiv, 65 leaves): ill. (some col.)
Includes bibliographical references (leaf 52-65)
en
Carrots -- Therapeutic use
Cannabis -- Therapeutic use
Nephrotoxicology -- Animal models
Cisplatin
Lebanese American University -- Dissertations
Dissertations, Academic
The Protective Effects of Daucus carota L. ssp. carota and Cannabis sativa L. Extracts against Cisplatin Induced Nephrotoxicity in Animal Models
Thesis
Summer
MS in Pharmaceutical Development And Management
SOP
201408952
Faour, Wissam
Daher, Costantine
Pharmaceutical Sciences
Mroueh, Mohamad
Shebaby, Wassim
sahar.altoufaily@lau.edu
Lebanese American University
Medicinal plants
Daucus carota
Cannabis sativay
Cannabis
Cisplatin
Nephrotoxicity
Cisplatin-induced nephrotoxicit
Lebanese American University
ORIGINAL
Sahar_Al_Toufaily_Thesis_Redacted.pdf
Sahar_Al_Toufaily_Thesis_Redacted.pdf
application/pdf
2160472
https://laur.lau.edu.lb:8443/bitstream/10725/13726/1/Sahar_Al_Toufaily_Thesis_Redacted.pdf
08c9c9f42083135f46f83b5648121bef
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13726/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/13726
oai:laur.lau.edu.lb:10725/13726
2022-06-30 11:48:49.562
DSpace at LAU
joseph.sayah@lau.edu.lb
TEVCQU5FU0UgQU1FUklDQU4gVU5JVkVSU0lUWSBOT04tRVhDTFVTSVZFIERJU1RSSUJVVElPTiBMSUNFTlNFIA0KDQpCeSBzaWduaW5nIGFuZCBzdWJtaXR0aW5nIHRoaXMgbGljZW5zZSwgeW91ICh0aGUgYXV0aG9yKHMpIG9yIGNvcHlyaWdodCBvd25lcikgZ3JhbnRzIHRoZSBMZWJhbmVzZSBBbWVyaWNhbiBVbml2ZXJzaXR5IChMQVUpIHRoZSBub24tZXhjbHVzaXZlIHJpZ2h0IHRvIHJlcHJvZHVjZSwgdHJhbnNsYXRlIChhcyBkZWZpbmVkIGJlbG93KSwgYW5kL29yIGRpc3RyaWJ1dGUgeW91ciBzdWJtaXNzaW9uIChpbmNsdWRpbmcgdGhlIGFic3RyYWN0KSB3b3JsZHdpZGUgaW4gcHJpbnQgYW5kIGVsZWN0cm9uaWMgZm9ybWF0cyBhbmQgaW4gYW55IG1lZGl1bSwgaW5jbHVkaW5nIGJ1dCBub3QgbGltaXRlZCB0byBhdWRpbyBvciB2aWRlby4gWW91IGFncmVlIHRoYXQgTEFVIG1heSwgd2l0aG91dCBjaGFuZ2luZyB0aGUgY29udGVudCwgdHJhbnNsYXRlIHRoZSBzdWJtaXNzaW9uIHRvIGFueSBtZWRpdW0gb3IgZm9ybWF0IGZvciB0aGUgcHVycG9zZSBvZiBwcmVzZXJ2YXRpb24uIFlvdSBhbHNvIGFncmVlIHRoYXQgTEFVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yIHB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrdXAgYW5kIHByZXNlcnZhdGlvbi4gWW91IHJlcHJlc2VudCB0aGF0IHRoZSBzdWJtaXNzaW9uIGlzIHlvdXIgb3JpZ2luYWwgd29yaywgYW5kIHRoYXQgeW91IGhhdmUgdGhlIHJpZ2h0IHRvIGdyYW50IHRoZSByaWdodHMgY29udGFpbmVkIGluIHRoaXMgbGljZW5zZS4gWW91IGFsc28gcmVwcmVzZW50IHRoYXQgeW91ciBzdWJtaXNzaW9uIGRvZXMgbm90LCB0byB0aGUgYmVzdCBvZiB5b3VyIGtub3dsZWRnZSwgaW5mcmluZ2UgdXBvbiBhbnlvbmXigJlzIGNvcHlyaWdodC4gSWYgdGhlIHN1Ym1pc3Npb24gY29udGFpbnMgbWF0ZXJpYWwgZm9yIHdoaWNoIHlvdSBkbyBub3QgaG9sZCBjb3B5cmlnaHQsIHlvdSByZXByZXNlbnQgdGhhdCB5b3UgaGF2ZSBvYnRhaW5lZCB0aGUgdW5yZXN0cmljdGVkIHBlcm1pc3Npb24gb2YgdGhlIGNvcHlyaWdodCBvd25lciB0byBncmFudCBMQVUgdGhlIHJpZ2h0cyByZXF1aXJlZCBieSB0aGlzIGxpY2Vuc2UsIGFuZCB0aGF0IHN1Y2ggdGhpcmQtcGFydHkgb3duZWQgbWF0ZXJpYWwgaXMgY2xlYXJseSBpZGVudGlmaWVkIGFuZCBhY2tub3dsZWRnZWQgd2l0aGluIHRoZSB0ZXh0IG9yIGNvbnRlbnQgb2YgdGhlIHN1Ym1pc3Npb24uIElGIFRIRSBTVUJNSVNTSU9OIElTIEJBU0VEIFVQT04gV09SSyBUSEFUIEhBUyBCRUVOIFNQT05TT1JFRCBPUiBTVVBQT1JURUQgQlkgQU4gQUdFTkNZIE9SIE9SR0FOSVpBVElPTiBPVEhFUiBUSEFOIExBVSwgWU9VIFJFUFJFU0VOVCBUSEFUIFlPVSBIQVZFIEZVTEZJTExFRCBBTlkgUklHSFQgT0YgUkVWSUVXIE9SIE9USEVSIE9CTElHQVRJT05TIFJFUVVJUkVEIEJZIFNVQ0ggQ09OVFJBQ1QgT1IgQUdSRUVNRU5ULiBMQVUgd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZSBzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMgbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLg==
oai:laur.lau.edu.lb:10725/138892023-11-08T10:42:51Zcom_10725_2058col_10725_2074
Ismail, Jana
2022-07-28T05:51:08Z
2022-07-28T05:51:08Z
2022
2022-05-13
http://hdl.handle.net/10725/13889
https://doi.org/10.26756/th.2022.401
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Cannabidiol (CBD) is one of the most abundant and commonly used cannabinoid of the Cannabis plant. Unlike tetrahydrocannabinol (THC), it lacks psychoactive properties, and thus it is considered to be a uniquely attractive cannabinoid for study. It has been used to treat various ailments, including epilepsy, anxiety, psychosis, inflammation, and cancer. Various in vitro, and to a lesser extent in vivo, studies have demonstrated the anti-cancer activity of CBD on different cancer cell types, and a few others showed that combining CBD with different chemotherapeutic agents exhibited variable interactions, ranging from antagonism, additive effect, and synergism. Few studies examined the anticancer activity of CBD, as well as its combination with cisplatin or paclitaxel, on ovarian cancer. Hence, the current study aimed to evaluate the anti-cancer activity of CBD, extracted from Lebanese Cannabis sativa plant, as monotherapy and in combination with conventional chemotherapeutic drugs cisplatin or paclitaxel on human ovarian adenocarcinoma OVCAR-3 and SK-OV-3 cell lines. CBD was extracted by Liquid Column Chromatography and confirmed by GC-MS. Cell survival was evaluated using the MTS cell proliferation assay. Monotherapy with CBD demonstrated a dose-dependent tumor growth inhibition at 72h, with the IC50 being 12.5 μg/ml for OVCAR-3 cell line and 12.3 μg/ml for SK-OV-3 cell line. The IC50 of cisplatin against OVCAR-3 and SK-OV-3 cell lines (1.1 and 3.3 μg/ml, respectively), and that of paclitaxel against SK-OV-3 cell line (9.9 μg/ml) were obtained as well. Additionally, applying the Chou-Talalay method using the CompuSyn software, the combination indexes (CI) were calculated to predict the interaction between CBD and the chemotherapeutic agents. The combination of CBD with either cisplatin or paclitaxel exhibited a significant antagonistic interaction against SK-OV-3 cell line when compared to individual treatment (CI > 1). However, at high cell growth inhibition rates (95% and 97%), mild synergism is detected (CI < 1) when combining CBD with cisplatin against this specific cell line. Thus, according to Drug Reduction Index (DRI), a combination of 6-fold less concentration of cisplatin with 1.3-fold less concentration of CBD yields a 95% cell growth inhibition. This synergistic interaction was confirmed in an in vitro experimentation setting. Pure antagonism was detected however when combining CBD and cisplatin against OVCAR-3 cell line. Evaluating the effect of CBD combined with paclitaxel against SK-OV-3 cell line demonstrated antagonism on all relevant inhibitory effect levels. Nonetheless, priming SK-OV-3 cells with CBD for 24h to sensitize them to the effect of cisplatin or paclitaxel treatment has shown to decrease the IC50 of the chemotherapeutic drugs. Similar results were revealed when the cells were primed with cisplatin or paclitaxel prior to be treated with CBD. The results suggest the potential benefit of sequential, rather than simultaneous, administration of CBD and chemotherapy to enhance therapy and overcome resistance. These findings, while demonstrating the potential benefit of CBD in treating ovarian cancer, call for additional caution when combining it with chemotherapeutic agents, specifically cisplatin and paclitaxel, as the effect is shown to be cell line and drug specific. Further studies are required for the validation of the results and better understanding of these interactions.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-07-28T05:51:08Z
No. of bitstreams: 1
ARC_CAT_ACQ_Jana_Ismail_Thesis_Redacted.pdf: 2187902 bytes, checksum: 3891a527b9be0beb170a7fb768081802 (MD5)
Made available in DSpace on 2022-07-28T05:51:08Z (GMT). No. of bitstreams: 1
ARC_CAT_ACQ_Jana_Ismail_Thesis_Redacted.pdf: 2187902 bytes, checksum: 3891a527b9be0beb170a7fb768081802 (MD5)
Previous issue date: 2022-05-13
1 online resource (xviii, 91 leaves): ill. (some col.)
Includes bibliographical references (leaf 80-91)
en
Cannabis -- Therapeutic use
Ovaries -- Cancer -- Treatment
Cisplatin
Platinum compounds -- Therapeutic use
Lebanese American University -- Dissertations
Dissertations, Academic
Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines
Thesis
Spring
MS in Pharmaceutical Development And Management
SOP
201300485
Daher, Costantine
Taleb, Robin
Pharmaceutical Sciences
Mroueh, Mohammad
Shebaby, Wassim
jana.ismail@lau.edu
Lebanese American University
Cannabis
CBD
Ovarian Cancer
Cisplatin
Paclitaxel
Synergism
Antagonism
Sensitize
Lebanese American University
ORIGINAL
Jana_Ismail_Thesis_Redacted.pdf
Jana_Ismail_Thesis_Redacted.pdf
application/pdf
2187902
https://laur.lau.edu.lb:8443/bitstream/10725/13889/3/Jana_Ismail_Thesis_Redacted.pdf
3891a527b9be0beb170a7fb768081802
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13889/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/13889
oai:laur.lau.edu.lb:10725/13889
2023-11-08 12:42:51.525
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/139452022-08-23T06:12:15Zcom_10725_2058col_10725_2074
Rached, Stephanie
2022-08-17T08:36:14Z
2022-08-17T08:36:14Z
2022
2022-05-23
http://hdl.handle.net/10725/13945
https://doi.org/10.26756/th.2022.427
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Globalization of the pharmaceutical supply chain introduced many new challenges requiring innovative technologies to ensure patients’ access to safe and effective medicine. Adding a unique identifier and implementing a track and trace system on pharmaceuticals allow the traceability of products across the supply chain, ensuring quality by reducing counterfeit products, facilitating the recall process, increasing transparency and on the long run speeding up the reimbursement process by third party payers. There are several barriers preventing the implementation of the track and trace system in Lebanon. The aim of this operational research is to identify these barriers in local pharmaceutical institutions mainly local manufacturers and pharmacies; and providing recommendations to policymakers. Through a three-steps operational research, data was collected from local manufacturers through structured or semi-structured interviews, data was also collected form a purposive sample of pharmacies
through focus groups and interviews, and finally key informants and policy makers were interviewed for a presentation of results and providing recommendations. Descriptive statistics were used to analyze quantitative results, while thematic analysis was used for qualitative data followed by exploratory data analysis. Different themes were identified for the barriers to implementation: financial, logistic, regulatory, internal planning/human resources and infrastructure issues/context specific.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-08-17T08:36:14Z
No. of bitstreams: 1
CAT_ACQ_Stephanie_Joseph_Rached_Thesis_Redacted.pdf: 5029991 bytes, checksum: 882b1e1f21e30dd8146f0451d9d0dbdf (MD5)
Made available in DSpace on 2022-08-17T08:36:14Z (GMT). No. of bitstreams: 1
CAT_ACQ_Stephanie_Joseph_Rached_Thesis_Redacted.pdf: 5029991 bytes, checksum: 882b1e1f21e30dd8146f0451d9d0dbdf (MD5)
Previous issue date: 2022-05-23
1 online resource (xiv, 83 leaves): ill. (chiefly col.), col. map
Bibliography: leaf 73-79.
en
Pharmaceutical industry -- Standards -- Lebanon
Product counterfeiting -- Lebanon
Drugs -- Marketing -- Lebanon
Pharmaceutical ethics -- Lebanon
Lebanese American University -- Dissertations
Dissertations, Academic
Barriers to the Implementation of a Unique Identifier and a Track and Trace System in the Lebanese Pharmaceutical Sector
Thesis
Spring
MS in Pharmaceutical Development And Management
SOP
200703031
Hamra, Rasha
Kanbar, Roy
Pharmaceutical Sciences
Dimassi, Hani
stephanie.rached@lau.edu
Lebanese American University
Pharmaceutical Industry
Unique Identifier
Track and Trace
Serialization
Pharmaceutical Supply Chain
Counterfeit
Implementation Barriers.
Recommendations
Policymakers
Lebanese American University
ORIGINAL
Stephanie_Joseph_Rached_Thesis_Redacted.pdf
Stephanie_Joseph_Rached_Thesis_Redacted.pdf
application/pdf
5029991
https://laur.lau.edu.lb:8443/bitstream/10725/13945/3/Stephanie_Joseph_Rached_Thesis_Redacted.pdf
882b1e1f21e30dd8146f0451d9d0dbdf
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/13945/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/13945
oai:laur.lau.edu.lb:10725/13945
2022-08-23 09:12:15.932
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/142022022-11-02T10:46:28Zcom_10725_2058col_10725_2074
Hatoum, Fatina
2022-11-02T10:45:54Z
2022-11-02T10:45:54Z
2022
2022-07-14
http://hdl.handle.net/10725/14202
https://doi.org/10.26756/th.2022.506
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
The Cannabis plant is the most versatile herbal remedy used for the treatment of various medical conditions, including pain, epilepsy, depression, anxiety, and post-traumatic stress disorder. Stress is a normal part of life, and stress responses can vary in different people. Stress-susceptible individuals become prone to depression, while resilient individuals lead a normal life. Limited literature is available about the pharmacological effects of Lebanese Cannabis oil on depression and anxiety disorders. Accordingly, the current research study examined the therapeutic effects of Cannabis oil extracted from the Lebanese Cannabis sativa plant on resilience to stress and its ability to rescue depression and anxiety-like behaviors in female animal models. Pre-treatment and post-treatment protocols were carried out using Cannabis oil to evaluate its anti-depressive effects. In the pre-treatment protocol, female C57BL/6 mice received daily injections of Cannabis oil (5 mg/kg and 20 mg/kg) for five days before and during the induction of depression-like behavior by using several types of stressors for nine days. At the end of the stress paradigm, the animal behavioral was assessed using the social interaction (SI) test. In the post-treatment protocol, female C57BL/6 mice were subjected to daily Chronic Variable Stress (CVS) for nine days. On day 10, the behavior of the mice was assessed using the SI test and animals were divided into susceptible or resilient to stress. Only animals that were classified as susceptible to stress received vehicle or Lebanese Cannabis oil i.p injection treatment (doses of 5 mg/kg and 20 mg/kg). The results showed that intraperitoneal injections of Lebanese Cannabis oil at doses of 5 mg/kg and 20 mg/kg rescued depression-like behaviors induced by the CVS. Therefore, Cannabis oil significantly rescues social avoidance behavior and promotes social interaction. These promising findings call for additional studies to gain a better understanding of the potential effect of Lebanese Cannabis oil on stress and anxiety disorders by studying the effects of whole plant or its major phytocannabinoids, Cannabidiol (CBD) and/or tetrahydrocannabinol (THC).
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2022-11-02T10:45:54Z
No. of bitstreams: 1
Fatina_Hatoum_ThesisGW_Redacted.pdf: 2548697 bytes, checksum: 44f12ad562cc80b910502159f3d261b1 (MD5)
Made available in DSpace on 2022-11-02T10:45:54Z (GMT). No. of bitstreams: 1
Fatina_Hatoum_ThesisGW_Redacted.pdf: 2548697 bytes, checksum: 44f12ad562cc80b910502159f3d261b1 (MD5)
Previous issue date: 2022-07-14
1 online resource (xiii, 71 leaves): ill. (some col.)
Includes bibliographical references (leaves 50-71)
en
Cannabis -- Therapeutic use
Cannabinoids -- Physiological effect
Neurobehavioral disorders -- Treatment
Depression, Mental -- Treatment
Lebanese American University -- Dissertations
Dissertations, Academic
Potential Therapeutic Effects of Lebanese Cannabis oil in Female Mouse Models of Neuropsychiatric Disorders
Thesis
Summer
MS in Pharmaceutical Development And Management
SOP
201404480
Shebaby, Wassim
Faour, Wissam
Pharmaceutical Sciences
Mroueh, Mohamad
Sleiman, Sama
fatina.hatoum@lau.edu
Lebanese American University
Lebanese Cannabis oil
Chronic Variable Stress
Social Interaction
Anxiety
Elevated Plus Maze
Open Field
Depression
Lebanese American University
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/14202/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
ORIGINAL
Fatina_Hatoum_ThesisGW_Redacted.pdf
Fatina_Hatoum_ThesisGW_Redacted.pdf
application/pdf
2548697
https://laur.lau.edu.lb:8443/bitstream/10725/14202/1/Fatina_Hatoum_ThesisGW_Redacted.pdf
44f12ad562cc80b910502159f3d261b1
MD5
1
10725/14202
oai:laur.lau.edu.lb:10725/14202
2022-11-02 12:46:28.112
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/145602023-11-09T10:32:43Zcom_10725_2058col_10725_2074
Frem, Jean-Pierre
2023-03-14T06:58:44Z
2023-03-14T06:58:44Z
2022
2022-12-30
http://hdl.handle.net/10725/14560
https://doi.org/10.26756/th.2022.517
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Chewable lozenges are easy to use, and highly flavored oral dosage forms used to deliver active ingredients, while providing high patient compliance rates. This work targets the development of chewable lozenges containing multiple natural active ingredients for the treatment of erectile dysfunction. Five batches were developed and analyzed consecutively by adjusting specific processes and material parameters such as the compounding procedure, and excipient quantities based on the physical appearance, stickiness, texture, chewiness, and taste of the lozenges. The most optimal batch obtained is batch “5” and includes adjustments to the compounding procedure to prepare the gelatin base separately while maintaining a heating temperature of 65-70˚C and a mixing speed of 750 rpm and maintaining a lower temperature of 50-60˚C with a mixing speed of 500 rpm while adding the active ingredients. Adjustments of the total liquid content was made to obtain a volume of 1.55 ml/lozenge and a water content of 0.30 ml/lozenge. In addition, the rotary evaporation technique was implemented to remove 6.7 ml (55.83%) of ethanol from the Black Maca liquid extract. Among other adjustments, these were the most significant in impacting the physical parameters and more specifically the stickiness of the lozenges. This project illustrates the successful development of chewable lozenges as a dosage form for the delivery of multiple active natural ingredients with distinct mechanisms of action. Water and solvent contents like ethanol, and process parameters can impact the physical characteristics of the chewable lozenges.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2023-03-14T06:58:44Z
No. of bitstreams: 1
Jean_Pierre_Frem_Thesis_Redacted.pdf: 3089406 bytes, checksum: 5f46871713f22b1521455932a4bd1b6f (MD5)
Made available in DSpace on 2023-03-14T06:58:44Z (GMT). No. of bitstreams: 1
Jean_Pierre_Frem_Thesis_Redacted.pdf: 3089406 bytes, checksum: 5f46871713f22b1521455932a4bd1b6f (MD5)
Previous issue date: 2022-12-30
1 online resource (xv, 112 leaves): col. ill.
Includes bibliographical references (leaves 73-112)
en
Impotence -- Treatment
Drugs -- Physiological effect
Pharmaceutical chemistry
Drugs -- Side effects
Lebanese American University -- Dissertations
Dissertations, Academic
Novel Natural Based Chewable Lozenges for the Treatment of Erectile Dysfunction
Thesis
Fall
MS in Pharmaceutical Development And Management
SOP
201502895
Milane, Aline
Goldstein, Jimi
Pharmaceutical Sciences
Abdallah, Jad
jeanpierre.frem@lau.edu
Lebanese American University
Chewable Lozenges
Natural Ingredients
Drug Delivery
Process Parameters
Physical Characteristics
Batch
Rotary Evaporation
Lebanese American University
ORIGINAL
Jean_Pierre_Frem_Thesis_Redacted.pdf
Jean_Pierre_Frem_Thesis_Redacted.pdf
application/pdf
3089406
https://laur.lau.edu.lb:8443/bitstream/10725/14560/1/Jean_Pierre_Frem_Thesis_Redacted.pdf
5f46871713f22b1521455932a4bd1b6f
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/14560/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/14560
oai:laur.lau.edu.lb:10725/14560
2023-11-09 12:32:43.333
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/146022023-11-08T11:16:35Zcom_10725_2058col_10725_2074
Kyprianos, Shirine
2023-03-20T09:41:22Z
2023-03-20T09:41:22Z
2022
2022-12-30
http://hdl.handle.net/10725/14602
https://doi.org/10.26756/th.2022.536
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
The disruption of the soil's ecosystem causes a disturbance in microbial communities and leads to the emergence of dangerous resistant pathogens and most antibiotic resistance genes. An unknown bacterial strain was collected from a mushroom compost in the Lebanese soil as part of another project aiming to identify bacteria capable of being used in bio-cementation. Our study aims to identify and characterize the unknown strain, its features, behavior, and infectious potential. Standardized techniques were used to determine the morphology and staining properties of the bacteria, biochemical and physiological reactions, and susceptibility and resistance to different antimicrobial agents. Since the strain originated from a mushroom compost in the soil, potassium hydroxide ruled out fungal entities. The bacteria are Gram-negative, rod-shaped, obligate aerobes, non-spore forming and non-encapsulated, urease, coagulase, and catalase-positive, oxidase-negative, possessing β-hemolytic activity, and resistant to UV light. The bacterial strain did not form biofilms at the air liquid interface and produced calcium carbonate precipitates. Antimicrobial susceptibility tests were carried out using antibiotics of major classes and Cannabidiol (CBD) oil. The strain conferred resistance to azithromycin, doxycycline, and trimethoprim-sulfamethoxazole. CBD demonstrated bactericidal activity at low doses but did not have an effect at higher concentrations. Based on the results obtained, we determined that the strain belonged to the genus Gluconacetobacter.
All in all, these findings provide preliminary results related to the potential virulence of the bacterial species and its resistance to different antimicrobials. Future in vivo studies are required to determine the infectivity spectrum of the bacteria. Whole genome sequencing is also essential to detect and analyze resistance genes, virulence factors, and
clusters for the production of bio-cement.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2023-03-20T09:41:22Z
No. of bitstreams: 1
Shirine_Kyprianos_Thesis_Redacted.pdf: 1588679 bytes, checksum: 44beb97ed35fbed12e9a99d90339e7dd (MD5)
Made available in DSpace on 2023-03-20T09:41:22Z (GMT). No. of bitstreams: 1
Shirine_Kyprianos_Thesis_Redacted.pdf: 1588679 bytes, checksum: 44beb97ed35fbed12e9a99d90339e7dd (MD5)
Previous issue date: 2022-12-30
1 online resource (xv, 107 leaves): col. ill.
Includes bibliographical references (leaves 74-107)
en
Soil microbiology -- Lebanon
Microbial sensitivity tests
Soils -- Environmental aspects -- Case studies
Lebanese American University -- Dissertations
Dissertations, Academic
Identification and Characterization of a Novel Bacterial Species Found in the Lebanese Soil
Thesis
Fall
MS in Pharmaceutical Development And Management
SOP
201502510
Fayad, Nancy
Goldstein, Jimi
Pharmaceutical Sciences
Abdallah, Jad
shirine.kyprianos@lau.edu
Lebanese American University
Bacteria
Antimicrobial Resistance
Soil
Identification Tests
Antimicrobial Susceptibility Tests
Lebanese American University
ORIGINAL
Shirine_Kyprianos_Thesis_Redacted.pdf
Shirine_Kyprianos_Thesis_Redacted.pdf
application/pdf
1588679
https://laur.lau.edu.lb:8443/bitstream/10725/14602/1/Shirine_Kyprianos_Thesis_Redacted.pdf
44beb97ed35fbed12e9a99d90339e7dd
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/14602/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/14602
oai:laur.lau.edu.lb:10725/14602
2023-11-08 13:16:35.796
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/150902023-11-08T10:44:52Zcom_10725_2058col_10725_2074
Bylan, Diana
2023-10-20T09:44:54Z
2023-10-20T09:44:54Z
2023
2023-05-18
http://hdl.handle.net/10725/15090
https://doi.org/10.26756/th.2023.591
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Kidney disease is a main contributor to mortality and morbidity worldwide. Renal fibrosis is the most common and final manifestation of chronic kidney disease. To date, there are no medications that target kidney cells or kidney fibrosis. The aim of this study is to evaluate the effect of Cannabis oil extract in the management of renal fibrosis in Folic acid-induced renal injury model in Sprague Dawley rats. Folic acid is known to accumulate easily in large amounts in the kidney at the proximal tubule segment when compared to other tissues due to the high content of its receptors in the kidneys. Folic acid was administered as a single dose of 250 mg/kg to induce nephrotoxicity in rats. Cannabis oil extract was administered at increasing doses of 5, 10, or 20 mg/kg to the Folic acid-treated groups for 2 weeks. Another group of rats was given 20mg/Kg Cannabis oil for 5 days followed by Folic acid administration on day 6. Body weight of rats were monitored during the study, serum creatinine, urea, and electrolytes were measured as well as pathological examination of the kidney and heart. Rats that were injected with Folic acid showed a marked reduction in body weight and increase in serum creatinine in comparison to the control group. Treatment with 20mg/Kg Cannabis oil caused a significant increase in body weight compared to the Folic acid treated group. In addition, a significant decrease in serum creatinine was observed in groups receiving cannabis extract at the doses of 5 and 10 mg/kg. Serum sodium was significantly reduced in all the groups receiving Cannabis oil extract. Cannabis oil ameliorated renal and cardiac pathology abnormalities induced by Folic acid in a dose dependent manner. In conclusion, the current results reveal a potential therapeutic and protective effect of Cannabis oil extract in renal fibrosis.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2023-10-20T09:44:54Z
No. of bitstreams: 1
Diana_Jihad_Bylan_Thesis ACQ_Redacted.pdf: 1219448 bytes, checksum: 89353dc08a257fd58b8877dbb0ba3826 (MD5)
Made available in DSpace on 2023-10-20T09:44:54Z (GMT). No. of bitstreams: 1
Diana_Jihad_Bylan_Thesis ACQ_Redacted.pdf: 1219448 bytes, checksum: 89353dc08a257fd58b8877dbb0ba3826 (MD5)
Previous issue date: 2023-05-18
1 online resource (xii, 48 leaves):ill. (some col.)
Includes bibliographical references (leaves 37-48)
en
Kidneys -- Diseases
Cannabis -- Therapeutic use
Cannabinoids -- Physiological effect
Nephrotoxicology -- Animal models
Lebanese American University -- Dissertations
Dissertations, Academic
Efficacy of Lebanese Cannabis Oil Extract in the Treatment of Folic Acid-Induced Renal Fibrosis in Rats
Thesis
Spring
Doctor of Pharmacy
SOP
201503911
Shebaby, Wassim
Kanbar, Roy
Pharmaceutical Sciences
Mroueh, Mohamad
Faour, Wissam
diana.bylan@lau.edu
Lebanese American University
Nephrotoxicity
Renal fibrosis
Cannabis oil extract
Cannabis Sativa
Folic acid
Lebanese American University
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/15090/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
ORIGINAL
Diana_Jihad_Bylan_Thesis_Redacted.pdf
Diana_Jihad_Bylan_Thesis_Redacted.pdf
application/pdf
1219448
https://laur.lau.edu.lb:8443/bitstream/10725/15090/3/Diana_Jihad_Bylan_Thesis_Redacted.pdf
89353dc08a257fd58b8877dbb0ba3826
MD5
3
10725/15090
oai:laur.lau.edu.lb:10725/15090
2023-11-08 12:44:52.64
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/151372023-11-09T10:40:42Zcom_10725_2058col_10725_2074
Abou Younes, Nour
2023-10-24T09:25:31Z
2023-10-24T09:25:31Z
2023
2023-05-18
http://hdl.handle.net/10725/15137
https://doi.org/10.26756/th.2023.622
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
The glycation reaction is a non-enzymatic reaction characterized by and spontaneous binding of sugar molecules and protein. This study focuses on the glycation process at the level of proteins. Protein glycation is initiated by a condensation reaction between the carbonyl of a reducing sugar with the amino or thiol group of a protein. Advanced glycation
end products (AGEs) are the byproduct of the glycation reaction. At the level of the proteins, AGEs are glycated cross-linked proteins that aggregate with time and lose their function. Glycation was classified as an irreversible one-way reaction until the preexisting DJ-1 chaperone protein was identified as a deglycase protein. Since DJ-1 is a highly
conserved protein a DJ-1-derived protein called ND-13 was developed and presented agonistic activity to DJ-1. This study aims to investigate the role of DJ-1 in the glycation process of skin and plasma proteins in mice models to better understand the mechanism of action of DJ-1. AGEs formation was induced in mice models by either passive exposure to
smoke and/or intraperitoneal D-ribose injection. Mice were then treated with ND-13 to identify through it the deglycase activity of DJ-1.Overall, the findings of this study indicate that the glycation process in the skin might need more than just a few weeks to form the early and intermediate glycation products, this was translated by the significant increase of
DJ-1 levels after 8 weeks of treatment with an exogenous glycating agent compared to week 4. In comparison to the other groups, the group treated with ND-13 presented much higher levels of DJ-1 which suggest that ND-13 might present an additive agonistic effect to the endogenous deglycase DJ-1.In contrast, levels of DJ-1 were not detected at the level
of the plasma, this might contribute by further demonstrating that DJ-1 might be an intracellular protein that under oxidative stress translocate into the nucleus or is excreted into the extracellular matrix of the tissue to protect act as an antioxidant and delicate protein to protect both environments. Therefore, our findings propose that DJ-1 might be
upregulated by a significant increase in carbonyl stress in a time dependent manner, further contributing to the preexisting literature about the deglycase activity of DJ-1. However, more perspective studies are needed to identify tissue-specificity of DJ-1 protein.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2023-10-24T09:25:31Z
No. of bitstreams: 1
Nour_C_Abou_Younes_Thesis_Redacted.pdf: 3632033 bytes, checksum: 6b28eebae85f6708f78cd71641b51a75 (MD5)
Made available in DSpace on 2023-10-24T09:25:31Z (GMT). No. of bitstreams: 1
Nour_C_Abou_Younes_Thesis_Redacted.pdf: 3632033 bytes, checksum: 6b28eebae85f6708f78cd71641b51a75 (MD5)
Previous issue date: 2023-05-18
1 online resource (xii, 74 leaves):col. ill.
Includes bibliographical references (leaves 43-54).
LAU.ACUC.SOP.JA1.9/June/2022
en
Proteins -- Research -- Methodology
Proteins -- Analysis
Glycosylation
Skin absorption
Lebanese American University -- Dissertations
Dissertations, Academic
The Role of DJ-1 in the Glycation Process of Skin and Plasma Proteins in Mice Models
Thesis
Spring
MS in Pharmaceutical Development And Management
SOP
201706634
Stephan, Joseph
Fayad, Nancy
Pharmaceutical Sciences
Abdallah, Jad
nour.abouyounes01@lau.edu
Lebanese American University
Glycation
DJ-1
Deglycase function
AGEs
ND-13
Plasma Protein
Skin Proteins
Lebanese American University
ORIGINAL
Nour_C_Abou_Younes_Thesis_Redacted.pdf
Nour_C_Abou_Younes_Thesis_Redacted.pdf
application/pdf
3632033
https://laur.lau.edu.lb:8443/bitstream/10725/15137/1/Nour_C_Abou_Younes_Thesis_Redacted.pdf
6b28eebae85f6708f78cd71641b51a75
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/15137/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/15137
oai:laur.lau.edu.lb:10725/15137
2023-11-09 12:40:42.039
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/151602023-11-09T08:47:51Zcom_10725_2058col_10725_2074
Habchy, Chistabel
2023-11-01T09:55:01Z
2023-11-01T09:55:01Z
2023
2023-05-23
http://hdl.handle.net/10725/15160
https://doi.org/10.26756/th.2023.630
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
The current study investigated the therapeutic effect of Lebanese Cannabis oil extract against Sodium orthovanadate-induced nephrotoxicity. Sodium orthovanadate is a non-selective inhibitor of protein tyrosine phosphatases that are known to play major modulator roles in cell signaling and survival. Kidney is a major target for the toxicity of Sodium orthovanadate causing several types of renal injury, including glomerulosclerosis, inflammation and tubular damage. The effect of Cannabis oil on Sodium orthovanadate-induced nephrotoxicity was studied in vivo using Sprague Dawley male rat model. Rats were intraperitoneally injected with 10mg/Kg Sodium orthovanadate for 10 days followed by 5mg/Kg, 10mg/Kg, or 20mg/Kg intraperitoneal injection of Cannabis oil extract starting day 4 till day 10. Body weight of rats were monitored during the study and clinical parameters including serum urea, creatinine, and electrolytes were measured as well as kidney and heart pathology. Rats that were injected with Sodium orthovanadate displayed a marked reduction in body weight, increase in serum creatinine and urea in comparison to the control group. All doses of Cannabis oil caused significant decrease in serum urea, as well as in serum creatinine at a dose of 20mg/Kg. In addition, a marked reduction in renal vascular dilatation, scattered foci of acute tubular necrosis, and numerous mitosis in tubular cells was observed in Cannabis oil treated rats (20mg/Kg) as compared to the Sodium orthovanadate- treated group. In conclusion, the primary findings demonstrate a potential therapeutic effect of Cannabis oil on kidney damage induced by Sodium orthovanadate.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2023-11-01T09:55:01Z
No. of bitstreams: 1
Christabel_Boutros_Habchy_Thesis Redacted.pdf: 1920568 bytes, checksum: 67d8cad8a67fec3984a417b74e2e02e5 (MD5)
Made available in DSpace on 2023-11-01T09:55:01Z (GMT). No. of bitstreams: 1
Christabel_Boutros_Habchy_Thesis Redacted.pdf: 1920568 bytes, checksum: 67d8cad8a67fec3984a417b74e2e02e5 (MD5)
Previous issue date: 2023-05-23
1 online resource (xi, 45 leaves):ill. (some col.)
Includes bibliographical references (leaves 33-45).
en
Kidneys -- Diseases -- Case studies
Cannabis -- Therapeutic use
Cannabinoids -- Physiological effect
Nephrotoxicology -- Animal models
Lebanese American University -- Dissertations
Dissertations, Academic
Therapeutic Effect of Lebanese Cannabis Oil Extract in the Management of Sodium Orthovanadate-Induced Nephrotoxicity in Rats
Thesis
Spring
MS in Pharmaceutical Development And Management
SOP
201506428
Kanbar, Roy
Shebaby, Wassim
Pharmaceutical Sciences
Faour, Wissam
Mroueh, Mohamad
christabel.habchy@lau.edu
Lebanese American University
Sodium Orthovanadate
Cannabis Oil Extract
Nephrotoxicity
Renal Biomarkers
Lebanese American University
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/15160/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
ORIGINAL
Christabel_Boutros_Habchy_Thesis Redacted.pdf
Christabel_Boutros_Habchy_Thesis Redacted.pdf
application/pdf
1920568
https://laur.lau.edu.lb:8443/bitstream/10725/15160/1/Christabel_Boutros_Habchy_Thesis+Redacted.pdf
67d8cad8a67fec3984a417b74e2e02e5
MD5
1
10725/15160
oai:laur.lau.edu.lb:10725/15160
2023-11-09 10:47:51.734
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/152852024-01-23T07:20:00Zcom_10725_2058col_10725_2074
Awkar, Nai
2024-01-23T07:20:00Z
2024-01-23T07:20:00Z
2023
2023-07-27
http://hdl.handle.net/10725/15285
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Background: Cannabidiol (CBD) is a major non-psychotomimetic cannabinoid found in the Cannabis sativa plant with several pharmacological effects. Juvenile Diabetes is a major chronic illness that affects the life of patients. CBD presents desirable effects on hyperglycemia by protecting against oxidative stress and inflammation, having neuroprotective properties, and acting on receptors linked to glycemia. Thus, CBD has the potential to decrease HbA1C in diabetic patients (Diabetes Mellitus type 1) and improve their lives.
Objective: The current research aims to explore the pharmacological effect of CBD on Juvenile Diabetes in rat models, as well as the safety profile of CBD including toxicology studies on the liver and the pancreas.
Methods: The research was done by conducting experiments on young adult male Wistar rats. The rats were given streptozotocin (STZ) for Juvenile Diabetes induction. The rats were randomly assigned to four experiments for a total duration of 30 days. Each experiment contained a vehicle control group alongside several groups of different dosage regimens of CBD. Each Experiment consisted of a specific and required number of animals (according to the standardized toxicity tests for rodents).
Results: The animal data and findings from this study offer the opportunity for a safe and effective oral drug for the treatment of Juvenile Diabetes to be considered for further research and clinical trials.
Conclusion: The animal data from this study confirmed the safety of CBD when administered in different dosing regimens per body weight with NOAEL (the no-observed-adverse-effect level) = 150mg/kg. In addition, the results gave promising insights for considering CBD as an oral treatment option for juvenile diabetes as dose-dependent. The CBD dose of 50mg/kg when administered for 14 days was able to control blood glycemia values, body weights and produce insulin concentration levels that are close to normal values.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2024-01-23T07:20:00Z
No. of bitstreams: 1
Nai_Awkar_Thesis_Redacted.pdf: 2119511 bytes, checksum: 679c8ad0394e247eb08d2522785d2528 (MD5)
Made available in DSpace on 2024-01-23T07:20:00Z (GMT). No. of bitstreams: 1
Nai_Awkar_Thesis_Redacted.pdf: 2119511 bytes, checksum: 679c8ad0394e247eb08d2522785d2528 (MD5)
Previous issue date: 2023-07-27
1 online resource (xii, 38 leaves): col. ill.
Includes bibliographical references (leaves 28-30)
en
Diabetes in children--Treatment
Cannabis--Therapeutic use
Lebanese American University--Dissertations
Dissertations, Academic
Efficacy And Safety of Cannabidiol on Juvenile Diabetes Outcomes in Male Rats
Thesis
Summer
Doctor of Pharmacy
SOP
201503983
Fayyad, Nancy
Kabbara, Wissam
Pharmaceutical Sciences
Saab, Yolande
Lebanese American University
Juvenile Diabetes
Cannabidiol
Hyperglycemia
HbA1c
Insulin
Toxicology
Hepatology
Lebanese American University
ORIGINAL
Nai_Awkar_Thesis_Redacted.pdf
Nai_Awkar_Thesis_Redacted.pdf
application/pdf
2119511
https://laur.lau.edu.lb:8443/bitstream/10725/15285/1/Nai_Awkar_Thesis_Redacted.pdf
679c8ad0394e247eb08d2522785d2528
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/15285/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/15285
oai:laur.lau.edu.lb:10725/15285
2024-01-23 09:20:00.673
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/152892024-01-23T09:05:09Zcom_10725_2058col_10725_2074
Azar Atallah, Shirine
2024-01-23T09:03:57Z
2024-01-23T09:03:57Z
2023
2023-07-25
http://hdl.handle.net/10725/15289
https://doi.org/10.26756/th.2023.646
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Cannabis sativa L. has a long history of use in traditional medicine for various ailments as an analgesic, anticonvulsant, hypnotic, tranquilizer, and anti-inflammatory agent. Emerging evidence in preclinical studies has also demonstrated the anticancer effect of cannabinoids, which are the major components of the plant. Recent findings established the importance of the endocannabinoid system (ECS) in the maintenance of skin homeostasis. Hence, the current study aims to investigate the potential chemotherapeutic effects of Lebanese Cannabis sativa oil extract (COE) on in vivo and in vitro squamous cell carcinoma (SCC) models, and to determine its underlying mechanism of action. GCMS analysis of COE revealed the presence of two major cannabinoids, CBD (59.1%) and THC (20.2%). Cell proliferation assay (MTS) of COE-treated tumorigenic human epidermal keratinocytes (HaCaT-ras) showed a significant dose and time dependent cytotoxicity with IC50 of 19, 11 and 8 𝜇g/mL at 24, 48 and 72 hours, respectively. Flow cytometry on COE-treated HaCaT cells demonstrated an induction of apoptotic cell death. Western blot analysis confirmed the involvement of apoptosis via both the extrinsic and intrinsic pathways and implicated an additional alteration in autophagy. Reactive oxygen species (ROS) detection assay did not show a significant involvement of oxidative stress in the cytotoxicity of COE. The anti-tumor effect of COE was also evaluated using a DMBA/TPA skin carcinogenesis mouse model. Intraperitoneal treatment of mice with COE (10, 25 or 50 mg/kg; 9 weeks) showed a non-significant decrease in tumor volume with respect to control, without adverse effects on liver and kidney function. In conclusion, COE displayed a promising anticancer activity against SCC cells, by triggering apoptosis and causing alterations in autophagy. These findings highlight the need for additional studies to investigate the role of COE in the treatment of squamous cell carcinoma.
Submitted by Souad Hasbany (shasbany@lau.edu.lb) on 2024-01-23T09:03:57Z
No. of bitstreams: 1
Shirine_Elias_Azar_Atallah_Thesis_Redacted.pdf: 2900749 bytes, checksum: cc49ee583947888f3359a89ae7456321 (MD5)
Made available in DSpace on 2024-01-23T09:03:57Z (GMT). No. of bitstreams: 1
Shirine_Elias_Azar_Atallah_Thesis_Redacted.pdf: 2900749 bytes, checksum: cc49ee583947888f3359a89ae7456321 (MD5)
Previous issue date: 2023-07-25
1 online resource (xvi, 72 leaves): ill. (some col.)
Includes bibliographical references (leaves 60-72)
en
Squamous cell carcinoma--Treatment
Cannabis--Therapeutic use
Cannabis--Therapeutic use--Lebanon
Lebanese American University--Dissertations
Dissertations, Academic
Anticancer Effects of Lebanese Cannabis Oil Against in vivo and in vitro Models of Squamous Cell Carcinoma
Thesis
Summer
MS in Pharmaceutical Development And Management
SOP
201303514
Daher, Constantine
Rizk-Jamati, Sandra
Pharmaceutical Sciences
Mroueh, Mohamad
Shebaby, Wassim
shirine.azaratallah@lau.edu
Lebanese American University
Skin Cancer
Squamous Cell Carcinoma
Cannabis
Apoptosis
Autophagy
Lebanese American University
ORIGINAL
Shirine_Elias_Azar_Atallah_Thesis_Redacted.pdf
Shirine_Elias_Azar_Atallah_Thesis_Redacted.pdf
application/pdf
2900749
https://laur.lau.edu.lb:8443/bitstream/10725/15289/1/Shirine_Elias_Azar_Atallah_Thesis_Redacted.pdf
cc49ee583947888f3359a89ae7456321
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/15289/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/15289
oai:laur.lau.edu.lb:10725/15289
2024-01-23 11:05:09.599
DSpace at LAU
joseph.sayah@lau.edu.lb
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
oai:laur.lau.edu.lb:10725/152942024-01-25T12:04:02Zcom_10725_2058col_10725_2074
Awkar, Nai
2024-01-25T12:04:02Z
2024-01-25T12:04:02Z
2023
2023-07-27
http://hdl.handle.net/10725/15294
https://doi.org/10.26756/th.2023.642
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Background: Cannabidiol (CBD) is a major non-psychotomimetic cannabinoid found in the Cannabis sativa plant with several pharmacological effects. Juvenile Diabetes is a major chronic illness that affects the life of patients. CBD presents desirable effects on hyperglycemia by protecting against oxidative stress and inflammation, having neuroprotective properties, and acting on receptors linked to glycemia. Thus, CBD has the potential to decrease HbA1C in diabetic patients (Diabetes Mellitus type 1) and improve their lives. Objective: The current research aims to explore the pharmacological effect of CBD on Juvenile Diabetes in rat models, as well as the safety profile of CBD including toxicology studies on the liver and the pancreas. Methods: The research was done by conducting experiments on young adult male Wistar rats. The rats were given streptozotocin (STZ) for Juvenile Diabetes induction. The rats were randomly assigned to four experiments for a total duration of 30 days. Each experiment contained a vehicle control group alongside several groups of different dosage regimens of CBD. Each Experiment consisted of a specific and required number of animals (according to the standardized toxicity tests for rodents). Results: The animal data and findings from this study offer the opportunity for a safe and effective oral drug for the treatment of Juvenile Diabetes to be considered for further research and clinical trials. Conclusion: The animal data from this study confirmed the safety of CBD when administered in different dosing regimens per body weight with NOAEL (the no-observed-adverse-effect level) = 150mg/kg. In addition, the results gave promising insights for considering CBD as an oral treatment option for juvenile diabetes as dose-dependent. The CBD dose of 50mg/kg when administered for 14 days was able to control blood glycemia values, body weights and produce insulin concentration levels that are close to normal values.
Submitted by Antoinette Kattoura (antoinette.kattoura@lau.edu.lb) on 2024-01-25T12:04:02Z
No. of bitstreams: 1
ARC_CAT_ACQ-Nai_Awkar_Thesis.pdf: 687841 bytes, checksum: 8af0db907c41654655b1aac00389631c (MD5)
Made available in DSpace on 2024-01-25T12:04:02Z (GMT). No. of bitstreams: 1
ARC_CAT_ACQ-Nai_Awkar_Thesis.pdf: 687841 bytes, checksum: 8af0db907c41654655b1aac00389631c (MD5)
Previous issue date: 2023-07-27
1 online resource (xii, 38 leaves): col. ill.
Includes bibliographical references (leaves 28-30).
en
Diabetes in children--Treatment
Cannabis--Therapeutic use
Lebanese American University--Dissertations
Dissertations, Academic
Efficacy And Safety of Cannabidiol on Juvenile Diabetes Outcomes in Male Rats
Thesis
Summer
Doctor of Pharmacy
SOP
1997-01-03
201503983
Fayyad, Nancy
Kabbara, Wissam
Pharmaceutical Sciences
Saab, Yolande
Lebanese American University
Juvenile Diabetes
Cannabidiol
Hyperglycemia
HbA1c
Insulin
Toxicology
Hepatology
Lebanese American University
ORIGINAL
ARC_CAT_ACQ-Nai_Awkar_Thesis.pdf
ARC_CAT_ACQ-Nai_Awkar_Thesis.pdf
application/pdf
687841
https://laur.lau.edu.lb:8443/bitstream/10725/15294/1/ARC_CAT_ACQ-Nai_Awkar_Thesis.pdf
8af0db907c41654655b1aac00389631c
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1687
https://laur.lau.edu.lb:8443/bitstream/10725/15294/2/license.txt
080ec6d77e22d325ae84231dcfb55fea
MD5
2
10725/15294
oai:laur.lau.edu.lb:10725/15294
2024-01-25 14:04:02.708
DSpace at LAU
joseph.sayah@lau.edu.lb
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